fumaric acid bis-(2-dimethylamino-ethyl ester) | 86178-64-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: fumaric acid bis-(2-dimethylamino-ethyl ester)
• 英文别名: Fumarsaeure-bis-(2-dimethylamino-aethylester)；Fumarsaeure-bis-<2-dimethylamino-ethylester>；bis[2-(dimethylamino)ethyl] (E)-but-2-enedioate
• CAS: 86178-64-5
• 化学式: C₁₂H₂₂N₂O₄
• 分子量: 258.318
• InChiKey: HAHZVQOXFHJPOX-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  bis(2-(dimethylaminoethyl))fumarate dihydrochloride 在 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 以76 %的产率得到fumaric acid bis-(2-dimethylamino-ethyl ester)
  参考文献：
  名称：

  CN115043741

  摘要：

  公开号：

文献信息

• Aminoalkyl substituted esters and amides of fumaric acid for neutralizing malodor
  申请人：Flachsmann Felix

  公开号：US20070009475A1

  公开（公告）日：2007-01-11

  The present invention relates to aminoalkyl substituted fumarates and there use as malodor neutralisers.

  本发明涉及氨基烷基取代的富马酸酯及其作为异味中和剂的用途。
• Scale-Up and Development of a One-Step Process for the Synthesis of Succinylcholine
  作者：Brijesh M. Sharma、Nakul Telang、Daniel W. Cook、Justina M. Burns、Rodger W. Stringham、Kai O. Donsbach、Tai-Yuen Yue

  DOI：10.1021/acs.oprd.3c00322

  日期：2024.1.19

  describes a practical synthesis and scale-up of this active pharmaceutical ingredient (API) from readily available starting materials. Analytical methods were developed to identify and quantify impurities in the API. In addition, process development resulted in practical isolation and purification procedures, which avoid the need for a recrystallization step. The process has been scaled up to 25 g reproducibly

  氯化琥珀胆碱是一种神经肌肉阻滞剂，被世界卫生组织确定为基本药物。本文描述了从现成的起始材料中实际合成和放大这种活性药物成分 (API)。开发了分析方法来识别和量化 API 中的杂质。此外，工艺开发导致了实用的分离和纯化程序，从而避免了重结晶步骤。该工艺已分三批重复放大至 25 g，平均总产率和纯度达到 89%，符合 API 品质琥珀胆碱的 USP 和 ICH 指导规范。
• PRESSURE-SENSITIVE ADHESIVE COMPOSITION AND MOISTURE-PERMEABLE PRESSURE-SENSITIVE ADHESIVE TAPE, PRESSURE-SENSITIVE ADHESIVE DRUG COMPOSITION, AND PRESSURE-SENSITIVE ADHESIVE TAPE PREPARATION EACH CONTAINING THE COMPOSITION
  申请人：TEIJIN LIMITED

  公开号：EP1148106A1

  公开（公告）日：2001-10-24

  The adhesive agent composition of the present invention comprises from 50 to 90% by weight of an acrylic adhesive agent, 2.5 to 50% by weight of a polyhydric alcohol-containing liquid component, and 0.01 to 10% by weight of a salt of a mono- to tri-valence metal of an aliphatic acid that contains a hydrocarbon group of 8 to 18 carbon atoms. The adhesive agent composition shows good adhesion, cohesive force and permeability, and an adhesive drug composition having the above properties can be prepared by adding a drug (medicine, etc.) to the adhesive composition. An adhesive tape excellent in permeability or an adhesive tape preparation excellent in permeability and cutaneous absorption of the drug can be produced by coating a substrate with the adhesive agent composition or adhesive drug composition.

  本发明的粘合剂组合物包括 50%至 90%（按重量计）的丙烯酸粘合剂、2.5%至 50%（按重量计）的含多元醇液体成分，以及 0.01%至 10%（按重量计）的含有 8 至 18 个碳原子的烃基的脂肪族酸的一价至三价金属盐。粘合剂组合物具有良好的粘合力、内聚力和渗透性，通过在粘合剂组合物中添加药物（药品等），可以制备出具有上述特性的粘合药物组合物。通过在基材上涂覆该粘合剂组合物或粘合药物组合物，可以制备出渗透性极佳的胶带或渗透性和皮肤吸收药物性极佳的胶带制剂。
• CROSSLINKED POLYMER, PROCESS FOR PRODUCING THE SAME, ABSORBENT STRUCTURE, AND ABSORBENT ARTICLE
  申请人：Sanyo Chemical Industries, Ltd.

  公开号：EP1275669A1

  公开（公告）日：2003-01-15

  A crosslinked polymer (A) which comprises, as essential structural units, units derived from (a) one or more vinyl monomers selected from the group consisting of water-soluble vinyl monomers and/or vinyl monomers which become water-soluble upon hydrolysis and units derived from (b) a crosslinking agent and which satisfies the following requirements: (1): (X) ≧ 25g/g, (2): (Y) ≧ 15g/g, and (3): (Y) ≧ -0.54 (X) + 41. It has exceedingly high water retentivity and exceedingly high absorbing power under load. When applied to an absorbent structure and an absorbent article, the polymer has excellent absorbing performance. In the relationships, (X) is the amount of physiological saline retained through 1-hour absorption and (Y) is the amount of physiological saline absorbed through 1-hour standing under a load of 60 g/cm2.

  一种交联聚合物(A)，其基本结构单元包括(a)一种或多种乙烯基单体衍生的单 元，这些乙烯基单体选自由水溶性乙烯基单体和/或水解后变成水溶性的乙烯基单体 组成的组，以及(b)一种交联剂衍生的单元，并满足以下要求：(1):(X) ≧ 25g/g, (2)：(Y) ≧ 15 克/克，及 (3)：(Y) ≧ -0.54 (X) + 41。它具有极高的保水性和极高的负载吸附力。当应用于吸水结构和吸水物品时，该聚合物具有优异的吸水性能。在上述关系中，(X) 是在 60 克/平方厘米的负载下，通过 1 小时的吸收所保留的生理盐水量，(Y) 是在 60 克/平方厘米的负载下，通过 1 小时的静置所吸收的生理盐水量。
• Absorbent article containing a water-absorbent resin powder
  申请人：LIVEDO CORPORATION

  公开号：US10052401B2

  公开（公告）日：2018-08-21

  To provide an absorbent article that has a high absorption speed, is unlikely to cause a liquid to remain on a skin-contacting surface, has excellent dry feeling, and is unlikely to cause excreted body fluid to return. The present invention provides an absorbent article comprising an absorber composed of at least one absorbent layer, wherein a water-absorbent resin powder meeting the following requirements (a) to (d) is disposed in an uppermost layer of the absorber: (a) a bulk density: 0.45 g/ml to 0.62 g/ml; (b) an absorption speed by a vortex method: 20 seconds to 50 seconds; (c) a liquid-passing speed under load: 10 seconds or less; and (d) a moisture absorption blocking ratio: 5% or less.

  提供一种吸收速度快、不易使液体残留在皮肤接触面上、干爽感极佳且不易使排出体外的体液回流的吸收制品。本发明提供了一种吸收制品，它包括由至少一个吸收层组成的吸收器，其中符合以下要求（a）至（d）的吸水性树脂粉末被放置在吸收器的最上层：（a）体积密度：0.45 克/毫升至 0.62 克/毫升；（b）涡流法吸收速度：20 秒至 50 秒；（c）负载下液体通过速度：10 秒或更短；以及（d）吸水性树脂粉末的体积密度：0.45 克/毫升至 0.62 克/毫升：(d) 吸湿阻塞率：5%或更低。