2-(2,4-dichloro-phenyl)-1-methyl-ethylamine | 32560-77-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,4-dichloro-phenyl)-1-methyl-ethylamine
• 英文别名: 2-(2,4-Dichlor-phenyl)-1-methyl-aethylamin；[2-(2,4-dichlorophenyl)-1-methylethyl]amine；1-(2,4-Dichlorophenyl)propan-2-amine
• CAS: 32560-77-3；32633-69-5；32659-51-1
• 化学式: C₉H₁₁Cl₂N
• mdl: MFCD08452633
• 分子量: 204.099
• InChiKey: WFXOKSCQUWGEEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2,4-dichloro-phenyl)-1-methyl-ethylamine 、 2-三氟甲基苯甲酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以27%的产率得到N-[2-(2,4-dichloro-phenyl)-1-methylethyl]-2-trifluoromethylbenzamide
  参考文献：
  名称：

  EP1997800

  摘要：

  公开号：
• 作为产物：
  描述：

  1-(2,4-Dichlorphenyl)-2-nitropropen 在 lithium aluminium tetrahydride 作用下， 生成 2-(2,4-dichloro-phenyl)-1-methyl-ethylamine
  参考文献：
  名称：

  拟精神病的苯基烷基胺的结构活性关系。

  摘要：

  DOI：

  10.1021/jm00256a016

文献信息

• Design, Synthesis, and Fungicidal Activities of Novel 5-Methyl-1H-1,2,3- trizole-4-carboxyl Amide Analogues
  作者：Zhen-Jun Wang、Hui-Hui Yang、Lei Tian、Wei-Guang Zhao

  DOI：10.2174/1573406412666151112125006

  日期：2016.3.31

  that some of designed N-phenethyl-1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Sclerotinia sclerotiorum and Botrytis cinerea, while some of Nbenzyl- 1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Phytophthora capsici and Cercospora arachidicola. EC50 value of compound 5d against Cercospora arachidicola (6.6 µg/mL) was lower

  琥珀酸脱氢酶抑制剂（SDHIs）是具有酰胺键的杀菌剂，广泛用于控制由植​​物致病真菌引起的植物病害。由于新SDHI的广泛活动，它们引起了研究界的广泛关注。设计并合成了具有生物活性的1,2,3-三唑部分的一系列结构新颖的SDHI。生物活性筛选表明，某些设计的N-苯乙基-1,2,3-三唑-4-羧基酰胺类似物对菌核盘菌和灰葡萄孢表现出良好的杀真菌活性，而一些N苄基1,2,3-三唑-4-羧基酰胺类似物对辣椒疫霉和花生毛孢菌表现出良好的杀真菌活性。EC 50 化合物5d对阿拉伯头孢菌（Cercospora arachidicola）（6.6 µg / mL）的测定值低于百菌清（12.3 µg / mL）。
• N-(L-ALKYL-2-PHENYLETHYL)-CARBOXAMIDE DERIVATIVES AND USE THEREOF AS FUNGICIDES
  申请人：Stierli Daniel

  公开号：US20110207771A1

  公开（公告）日：2011-08-25

  Compounds of the formula (I) in which the substituents are as defined in claim 1 are suitable for use as microbiocides.

  公式（I）中的化合物，其中取代基如权利要求1所定义的那样，适用于用作微生物杀菌剂。
• N-2-(Hetero)Arylethylcarboxamide Derivative, and Pest-Controlling Agent Comprising the Same
  申请人：Oda Masatsugu

  公开号：US20110136831A1

  公开（公告）日：2011-06-09

  An N-2-(hetero)arylethylcarboxamide derivative represented by the formula (I) wherein R 1 and R 2 are each independently a hydrogen atom etc., R 3 and R 4 are each independently a hydrogen atom etc., each Y is independently a halogen atom; a (C 1 -C 6 )alkyl group optionally substituted by halogen atom(s) etc., n is an integer of 1 to 5, A is a specific substituted cyclic group, E is C—H; C—Y (Y is as defined above); or a nitrogen atom, a salt thereof, and a pest controlling agent containing the derivative or salt as an active ingredient show superior performance as compared to the prior art technique, and are is useful particularly as plant disease controlling agents or nematocides having a broad control spectrum at a low dose.

  一种N-2-(杂)芳基乙基羧酰胺衍生物，其化学式表示为(I)，其中R1和R2分别独立地表示氢原子等，R3和R4分别独立地表示氢原子等，每个Y独立地表示卤原子；一种(C1-C6)烷基，该烷基可选择地被卤原子等取代等，n为1至5的整数，A是一种特定的取代环状基团，E为C—H；C—Y（其中Y如上所定义）；或氮原子，其盐，以及含有该衍生物或盐作为活性成分的杀虫剂与先前技术相比表现出卓越性能，并且特别适用于具有广泛控制光谱的植物病害控制剂或线虫剂，剂量低。
• N-2-(hetero)arylethylcarboxamide derivative, and pest-controlling agent comprising the same
  申请人：Oda Masatsugu

  公开号：US08378114B2

  公开（公告）日：2013-02-19

  An N-2-(hetero)arylethylcarboxamide derivative represented by the formula (I) wherein R1 and R2 are each independently a hydrogen atom etc., R3 and R4 are each independently a hydrogen atom etc., each Y is independently a halogen atom; a (C1-C6)alkyl group optionally substituted by halogen atom(s) etc., n is an integer of 1 to 5, A is a specific substituted cyclic group, E is C—H; C—Y (Y is as defined above); or a nitrogen atom, a salt thereof, and a pest controlling agent containing the derivative or salt as an active ingredient show superior performance as compared to the prior art technique, and are is useful particularly as plant disease controlling agents or nematocides having a broad control spectrum at a low dose.

  化合物I的结构式如下：N-2-(杂)芳基乙基甲酰胺衍生物，其中R1和R2各自独立地为氢原子等，R3和R4各自独立地为氢原子等，每个Y独立地为卤素原子；一种（C1-C6）烷基，可选地被卤素原子等取代，n是1至5的整数，A是一种特定的取代环状基团，E是C-H；C-Y（其中Y如上定义）；或氮原子，其盐，以及含有该衍生物或盐作为活性成分的杀虫剂与先前的技术相比表现出优越性能，并且在低剂量下具有广泛控制光谱，特别适用于作为植物病害控制剂或线虫灭生剂。
• N-2-(HETERO)ARYLETHYLCARBOXAMIDE DERIVATIVE, AND PEST-CONTROLLING AGENT COMPRISING THE SAME
  申请人：NIHON NOHYAKU CO., LTD.

  公开号：EP1997800A1

  公开（公告）日：2008-12-03

  An N-2-(hetero)arylethylcarboxamide derivative represented by the formula (I) wherein R1 and R2 are each independently a hydrogen atom etc., R3 and R4 are each independently a hydrogen atom etc., each Y is independently a halogen atom; a (C1-C6)alkyl group optionally substituted by halogen atom(s) etc., n is an integer of 1 to 5, A is a specific substituted cyclic group, E is C-H; C-Y (Y is as defined above); or a nitrogen atom, a salt thereof, and a pest controlling agent containing the derivative or salt as an active ingredient show superior performance as compared to the prior art technique, and are useful particularly as plant disease controlling agents or nematocides having a broad control spectrum at a low dose.

  由式 (I) 代表的 N-2-(杂)芳基乙基甲酰胺衍生物 其中 R1 和 R2 各自独立地为氢原子等，R3 和 R4 各自独立地为氢原子等，Y 各自独立地为卤素原子、任选被卤素原子等取代的(C1-C6)烷基、n 是 1 至 5 的整数，A 是特定取代的环状基团，E 是 C-H；C-Y（Y 如上文所定义）；或氮原子，其盐和含有该衍生物或盐作为活性成分的害虫防治剂与现有技术相比表现出更优越的性能，尤其可用作植物病害防治剂或杀线虫剂，具有低剂量、广谱防治的特点。