11,15,25,29-tetramethyl-1,8-dioxa-16,17,23,24-tetraazacyclohentriaconta-15,24-diene-2,7,18,22-tetraone | 1220913-55-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: 11,15,25,29-tetramethyl-1,8-dioxa-16,17,23,24-tetraazacyclohentriaconta-15,24-diene-2,7,18,22-tetraone
• 英文别名: 11,15,25,29-tetramethyl-1,8-dioxa-16,17,23,24-tetrazacyclohentriaconta-15,24-diene-2,7,18,22-tetrone
• CAS: 1220913-55-2
• 化学式: C₂₉H₅₀N₄O₆
• 分子量: 550.739
• InChiKey: IGQCNPJTHYAUDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  39
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  己二酰氯 在 吡啶 作用下， 以 1,4-二氧六环 、 乙醚 为溶剂， 反应 96.0h， 生成 11,15,25,29-tetramethyl-1,8-dioxa-16,17,23,24-tetraazacyclohentriaconta-15,24-diene-2,7,18,22-tetraone
  参考文献：
  名称：

  Synthesis of macrocyclic azino and dihydrazido diesters by consecutive [2 + 1]- and [1 + 1]-condensations

  摘要：

  Efficient procedures for the synthesis of 21-24- and 28-31-membered macrocyclic azino diesters and dihydrazido diesters were developed starting from L-menthol, Delta(3)-carene, (+)-alpha-pinene, tetrahydropyran, and 4-methyltetrahydropyran. The key steps in these syntheses were consecutive [2 + 1]- and [1 + 1]-condensations. The 31-membered dihydrazido diester exhibited strong antibacterial activity.

  DOI：

  10.1134/s1070428011090260

文献信息

• Synthesis of symmetric macrocyclic diesterdihyrazides using successive [2+1]- and [1+1]-condensations
  作者：G. Yu. Ishmuratov、G. R. Mingaleeva、M. P. Yakovleva、R. R. Muslukhov、E. M. Vyrypaev、S. P. Ivanov、A. G. Tolstikov

  DOI：10.1007/s10600-010-9513-9

  日期：2010.3

  Potentially useful symmetric macrocyclic diesterdihydrazides were synthesized efficiently from available petrochemical products (tetrahydropyran and 4-methyltetrahydropyran) using successive [2+1]-condensation of 8-hydroxyoctan-2-one and its 6-methyl derivative with glutaric and adipic chlorides and [1+1]-condensation of the intermediate diketodiesters with glutaric dihydrazide.

  利用 8-羟基辛-2-酮及其 6-甲基衍生物与戊二酸和己二酸氯化物的连续 [2+1]- 缩合，以及中间二酮二酯与戊二酸二酰肼的 [1+1]- 缩合，从现有石化产品（四氢吡喃和 4-甲基四氢吡喃）中高效合成了潜在有用的对称大环二酯二酰肼。