S-(4-azidophenacyl)glutathione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-(4-azidophenacyl)glutathione
• 英文别名: 2-Amino-5-[[3-[2-(4-azidophenyl)-2-oxoethyl]sulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• 化学式: C₁₈H₂₂N₆O₇S
• 分子量: 466.475
• InChiKey: POHHFIIXXRDDJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  32
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  216
• 氢给体数：
  5
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  glutathion 、 4-叠氮苯甲酰甲基溴 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以65%的产率得到S-(4-azidophenacyl)glutathione
  参考文献：
  名称：

  能够结合谷胱甘肽或其二硫键的酶的光亲和标记

  摘要：

  描述了在N-末端或SH位点掺入芳基叠氮化物部分的几种谷胱甘肽类似物的合成和光解。这样的标记包括S-阻断的谷胱甘肽，N，S-阻断的谷胱甘肽和N，N'-阻断的谷胱甘肽二硫化物。S-（4-叠氮苯甲酰基）谷胱甘肽已用于共价标记酵母乙二醛酶I，牛肉肝乙二醛酶II和谷胱甘肽S-转移酶。N，S-双（4-叠氮基苯甲酰基）谷胱甘肽已用于标记假单胞菌属和牛肝中的共价甲醛脱氢酶。N，N′-双-（4-叠氮苯甲酰基）谷胱甘肽二硫化物已成功地用于共价标记酵母谷胱甘肽还原酶。

  DOI：

  10.1039/p19810003029

文献信息

• Modulation of cellular DNA repair activity to intercept malignancy
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US10188617B2

  公开（公告）日：2019-01-29

  Disclosed herein are methods for identifying compounds that enhance base excision repair, as well as compounds identified thereby and methods of using such compounds in the interception of malignancy, i.e. the prevention of progression of a disease from a state of susceptibility to active disease. Exemplified compounds are acetohexamide and related compounds, as well as benserazide and analogs thereof. Exemplified malignancies are those of human breast cells carrying mutations, in particular, SUM149 cells and HCC1937 cells, which cells carry BRCA1 mutations.

  本文公开了用于鉴定可增强碱基切除修复的化合物的方法，以及由此鉴定出的化合物和将此类化合物用于阻断恶性肿瘤的方法，即防止疾病从易感状态发展为活动性疾病的方法。示例化合物是乙酰己酰胺和相关化合物，以及苄丝肼及其类似物。示例性恶性肿瘤是携带突变的人类乳腺细胞，特别是携带 BRCA1 突变的 SUM149 细胞和 HCC1937 细胞。
• DIFFERENTIATED CELL POPULATION OF ENDOTHELIAL CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS, COMPOSITION, SYSTEM, KIT AND USES THEREOF
  申请人：CNC - Centro de Neurociências e Biologia Molecular - Universidade de Coimbra

  公开号：EP2935567B1

  公开（公告）日：2019-01-30
• METHODS FOR TREATING NEUROLOGICAL DISORDERS OR DAMAGE
  申请人：Tyers Mike

  公开号：US20090076019A1

  公开（公告）日：2009-03-19

  A clonogenic neurosphere assay is described that carries out high throughput screens (HTS) to identify potent and/or selective modulators of proliferation, differentiation and/or renewal of neural precursor cells, neural progenitor cells and/or self-renewing and multipotent neural stem cells (NSCs). Compositions comprising the identified modulators and methods of using the modulators and compositions, in particular to treat neurological disorders (e.g. brain or CNS cancer) or damage are also disclosed.
• MODULATON OF CELLULAR DNA REPAIR ACTIVITY TO INTERCEPT MALIGNANCY
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20160038444A1

  公开（公告）日：2016-02-11

  Disclosed herein are methods for identifying compounds that enhance base excision repair, as well as compounds identified thereby and methods of using such compounds in the interception of malignancy, i.e. the prevention of progression of a disease from a state of susceptibility to active disease. Exemplified compounds are acetohexamide and related compounds, as well as benserazide and analogs thereof. Exemplified malignancies are those of human breast cells carrying mutations, in particular, SUM149 cells and HCC1937 cells, which cells carry BRCA1 mutations.
• US8058243B2
  申请人：——

  公开号：US8058243B2

  公开（公告）日：2011-11-15