4'-pentyl-biphenyl benzyl alcohol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-pentyl-biphenyl benzyl alcohol
• 英文别名: (4'-pentylbiphenyl-4-yl)methanol；4-(hydroxymethyl)-4'-pentylbiphenyl；[4-(4-pentylphenyl)phenyl]methanol
• 化学式: C₁₈H₂₂O
• 分子量: 254.372
• InChiKey: MCTQOEFGMDKFHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4'-pentyl-biphenyl benzyl alcohol 生成 1-(氯甲基)-4-(4-戊基苯基)苯
  参考文献：
  名称：

  OKABEH, JOSIAKI;KITAMURA, TEHRUO;JOKOKURA, XISAO

  摘要：

  DOI：
• 作为产物：
  描述：

  4-戊基联苯-4’-羧酸 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以93%的产率得到4'-pentyl-biphenyl benzyl alcohol
  参考文献：
  名称：

  NIR light-directing self-organized 3D photonic superstructures loaded with anisotropic plasmonic hybrid nanorods

  摘要：

  自组织的三维超结构载有等离子混合纳米棒，在近红外光照射下，从体心立方结构转变为简单立方结构，这是由于金纳米棒的“光热效应”导致的。

  DOI：

  10.1039/c5cc06146f

文献信息

• Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain
  作者：Fabrizio Bordi、Silvia Rivara、Elisa Dallaturca、Caterina Carmi、Daniele Pala、Alessio Lodola、Federica Vacondio、Lisa Flammini、Simona Bertoni、Vigilio Ballabeni、Elisabetta Barocelli、Marco Mor

  DOI：10.1016/j.ejmech.2011.12.019

  日期：2012.2

  assignment of absolute stereochemistry, based on characteristic differences detected within each diastereomeric couple. The additional lipophilic group was tolerated by the receptor, supporting the hypothesis that the two regions described within the H3 receptor binding site can be simultaneously occupied by antagonists. Diastereoisomers with opposite chirality at the benzylic carbon showed limited or no

  在一系列以联苯核心和两个碱性基团为特征的组胺H 3拮抗剂中，我们鉴定出（S）-1-[4'-（（（2-甲基吡咯烷-1-基）甲基）联苯-4-基]甲基}哌啶作为先导支架，以在吡咯烷环附近的苄基碳上引入额外的亲脂性链。合成了一系列衍生物，并测试了它们对人和大鼠组胺H 3的结合亲和力受体，以及它们的拮抗剂效力。对于具有两个手性中心的化合物，合成步骤提供了非对映异构体对的混合物，将其通过快速色谱分离。结合实验NMR数据和分子动力学模拟，可以基于在每个非对映异构体对中检测到的特征差异来分配绝对立体化学。受体可以耐受另外的亲脂性基团，从而支持了H 3受体结合位点中描述的两个区域可以同时被拮抗剂占据的假说。在苄基碳上具有相反手性的非对映异构体在人和大鼠受体上均显示出有限的立体选择性或没有立体选择性。
• Efficient visible-light full-color tuning of self-organized helical superstructures enabled by fluorinated chiral switches
  作者：Lang Qin、Wei Gu、Yingying Chen、Jia Wei、Yanlei Yu

  DOI：10.1039/c8ra07657j

  日期：——

  Light-driven chiral switches have the ability to tune and control the self-organized helical superstructures of cholesteric liquid crystals (CLCs), resulting in the photo-induced reflection wavelength shift of the CLCs. A new type of axially chiral switch functionalized with fluorine atoms ortho to the azobenzene moiety is found to exhibit reversible visible-light-driven photoisomerization due to a

  光驱动手性开关具有调节和控制胆甾型液晶 (CLC) 自组织螺旋超结构的能力，从而导致 CLC 的光致反射波长偏移。由于反式和顺式的 n-π* 吸收带的分离，发现一种新型的轴向手性开关，用与偶氮苯部分邻位的氟原子官能化，表现出可逆的可见光驱动光异构化异构体。这些手性开关都具有高 HTP 值，并且具有 15.8 wt% 浓度的掺杂 CLC 在由 530 nm 和 445 nm 可见光驱动的整个可见光谱内显示出反射颜色的可逆动态调谐。还值得注意的是，由于氟化偶氮苯的顺式形式具有非常长的半衰期，热稳定性得到了改善。新设计的可见光驱动手性开关可能会拓宽 CLC 的应用，特别是在高能紫外光不利的领域。
• Acetylenes
  申请人：Hoffmann-La Roche Inc.

  公开号：US04528114A1

  公开（公告）日：1985-07-09

  Compounds of the formula ##STR1## wherein ring B stands for 1,4-phenylene or a trans-1,4-disubstituted cyclohexane ring and A stands for a group with 1 to 3 six-membered rings, which together with ring B represents a central group of formulae II-XIII; R.sup.1 signifies a straight-chain alkyl group containing 1 to 9 carbon atoms or when R.sup.1 is attached to a benzene, monofluorinated benzene or pyrimidine, ring R.sup.1 also signifies a straight-chain alkoxy group with 1 to 9 carbon atoms; and R.sup.2 signifies hydrogen, cyano or a straight-chain alkyl group containing 1 to 7 carbon atoms, their manufacture, liquid crystalline mixtures which contain said compounds and their use for electro-optical purposes are described. The compounds of formula I are especially valuable as components in liquid crystal mixtures and for the most part themselves have liquid crystalline properties.

  式子为##STR1##的化合物，其中环B代表1,4-苯基或反式1,4-二取代环己烷环，并且A代表一个含有1至3个六元环的基团，与环B一起表示式子II-XIII的中心基团；R1表示含1至9个碳原子的直链烷基或当R1连接苯、单氟苯或嘧啶时，环R1也表示含1至9个碳原子的直链烷氧基；R2表示氢、氰或含1至7个碳原子的直链烷基。描述了它们的制造、液晶混合物中包含这些化合物和它们用于电光目的的用途。公式I的化合物特别有价值作为液晶混合物中的组分，并且它们大部分本身具有液晶性质。
• Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives
  作者：Zhenkang Wang、Chunhua Ma、Yujie Wang、Qiang Xiao、Chenghui Xu、Yingxia Li

  DOI：10.1016/j.bmcl.2019.126685

  日期：2019.11

  C14 alkyl benzoate ABG001, derived from naturally occurring gentisides, was reported to exhibit neurotrophic activity which is similar to NGF (Nerve Growth Factor). In this research, ABG001 was modified by the strategy of isosteric replacement and conformational restriction with the purpose of improving the bioactivity. The cellular neurotrophic activity of those ABG001 derivatives were evaluated, among which 3-hydroxyquinolin-2-(1H)-one A3 and 4-decylphenol ester B7 displayed much better neurotrophic activity compared with ABG001, which highlights the potential of those novel scaffolds for future neurotrophic agent development.
• LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE USING THE SAME
  申请人：DIC Corporation

  公开号：US20170218271A1

  公开（公告）日：2017-08-03

  There is provided a liquid crystal composition containing at least one compound represented by General Formula (a). There is also provided a liquid crystal display device using such a liquid crystal composition. The liquid crystal composition of the present invention has the following properties without suffering reductions in refractive index anisotropy (Δn) and nematic phase-isotropic liquid phase transition temperature (T ni ): sufficiently low viscosity (η), sufficiently low rotational viscosity (γ 1 ), a large elastic constant (K 33 ), a high voltage holding ratio after UV exposure (VHR (UV)), and a negative dielectric anisotropy (Δ∈) with a large absolute value. A liquid crystal display device of, for example, a VA type that uses such a liquid crystal composition has a high response speed and excellent display quality with defective display being eliminated or reduced.