diamino benzanilide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diamino benzanilide
• 英文别名: Diaminobenzanilide；2,3-diamino-N-phenylbenzamide
• 化学式: C₁₃H₁₃N₃O
• 分子量: 227.266
• InChiKey: YDYSEBSNAKCEQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  diamino benzanilide 、 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbaldehyde 以 1,2-二氯乙烷 为溶剂， 生成 2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-N-phenyl-1H-benzo[d]imidazole-7-carboxamide
  参考文献：
  名称：

  Design, synthesis and inhibitory activity against human dihydroorotate dehydrogenase ( h DHODH) of 1,3-benzoazole derivatives bearing amide units

  摘要：

  A series of 1,3-benzoazole derivatives possessing amide moieties were designed, synthesized and evaluated as inhibitors against human dihydroorotate dehydrogenase (hDHODH). Compounds A11, A14 and A26 exhibited good to excellent activities against hDHODH at the concentration of 10 mu M. In particular, compound A14 displayed an IC50 value of 0.178 mu M with 2-fold preference over A771726. The result implied that a proper degree of steric size and electron density of the C-6 amide moiety was necessary to retain the inhibitory activity of the synthesized compounds. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2016.05.016
• 作为产物：
  描述：

  2-amino-3-nitrobenzoyl chloride 在 15% palladium on carbon 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 diamino benzanilide
  参考文献：
  名称：

  Discovery of novel 1,5-benzodiazepine-2,4-dione derivatives as potential anticancer agents

  摘要：

  A series of novel 1,5-benzodiazepine-2,4-dione derivatives with C-6 amide substituents were designed and synthesized using three-component reactions. The preliminary assays showed that most of them displayed moderate to good antitumor activities against human lung carcinoma (A549), human breast epithelial carcinoma (MCF-7), human colon carcinoma (HCT116), human cervical carcinoma (Hela) and Lewis lung carcinoma (2LL). Exhilaratingly, the activity level of 6m rivaled that of 5-Fluorouracil (5-Fu) against MCF-7 cell lines, which might be used as novel lead scaffold for potential anticancer development.

  DOI：

  10.1016/j.bmcl.2014.06.041

文献信息

• [EN] YELLOW ANIONIC DISAZO DYES<br/>[FR] COLORANTS DIAZO ANIONIQUES JAUNES
  申请人：CIBA SC HOLDING AG

  公开号：WO2003104333A1

  公开（公告）日：2003-12-18

  The present invention relates to novel yellow anionic dyes, a process for their preparation, certain novel intermediates necessary for their preparation and the use of these dyes for dyeing natural or synthetic materials, in particular, paper.

  本发明涉及新型黄色阴离子染料、其制备方法、制备所必需的某些新型中间体以及利用这些染料对天然或合成材料进行染色，特别是纸张的用途。
• Compound having oxadiazole structure and a dehydration-cyclization method for producing the same
  申请人：MORIYAMA Hideki

  公开号：US20090182171A1

  公开（公告）日：2009-07-16

  A compound having an oxadiazole structure which is obtained by dehydration-cyclization of a compound having a carbohydrazide structure using a chemical agent selected from acids and bases. The dehydration-cyclization of the compound having a carbohydrazide structure can be conducted under mild conditions at low cost.

  一种具有氧代唑结构的化合物，通过使用选自酸和碱的化学试剂，通过脱水-环化反应从具有羰基肼结构的化合物获得。具有羰基肼结构的化合物的脱水-环化反应可以在低成本的温和条件下进行。
• Organic solvent soluble metal complex azo dyes
  申请人：Smith J. Michael

  公开号：US20050192431A1

  公开（公告）日：2005-09-01

  The present invention relates to organic solvent soluble dyes. In particular, the invention relates to an organic solvent soluble metal complex azo dyes containing chelated metal atoms.

  本发明涉及有机溶剂可溶性染料。具体而言，本发明涉及一种含有螯合金属原子的有机溶剂可溶性金属络合偶氮染料。
• Laminate
  申请人：Watanabe Hisashi

  公开号：US20060204734A1

  公开（公告）日：2006-09-14

  A laminate having a metal foil layer, and a polyimide resin layer provided on the metal foil layer, wherein the polyimide resin layer is obtained by curing a coating of a polyimide resin precursor solution directly applied onto a surface of the metal foil layer, wherein the polyimide resin layer has a linear expansion coefficient in the range from 10 to 30 ppm/K, wherein the metal foil layer and the polyimide resin layer have a bonding strength therebetween of at least 0.5 kN/m in terms of 180° peel strength, and wherein the polyimide resin obtained from the polyimide resin precursor solution contains at least 50% by weight of a moiety having a structure represented by the following formula (1) shown in the specification.

  一种层压板，其具有金属箔层和设置在金属箔层上的聚酰亚胺树脂层，其中聚酰亚胺树脂层是通过将聚酰亚胺树脂前体溶液涂覆于金属箔层表面并固化而得到的，其中聚酰亚胺树脂层的线性膨胀系数在10至30 ppm/K范围内，其中金属箔层和聚酰亚胺树脂层之间的粘结强度至少为0.5 kN/m，以180°剥离强度表示，而从聚酰亚胺树脂前体溶液中获得的聚酰亚胺树脂至少含有50%重量的具有以下式(1)所示结构的基团。
• POLYIMIDE PRECURSOR, POLYIMIDE, AND MATERIALS TO BE USED IN PRODUCING SAME
  申请人：Takasawa Ryoichi

  公开号：US20130178597A1

  公开（公告）日：2013-07-11

  Disclosed is a novel co-polyimide precursor for producing a polyimide having high transparency. The co-polyimide precursor comprises a unit structure represented by general Formula (A1) and a unit structure represented by general Formula (A2): wherein, in general Formula (A1), R 1 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; and R 2 and R 3 each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkylsilyl group having 3 to 9 carbon atoms, wherein, in general Formula (A2), R 4 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 5 and R 6 each independently represent a hydrogen, an alkyl group having 1 to 6 carbon atoms, or an alkylsilyl group having 3 to 9 carbon atoms; and X represents a tetravalent group other than those represented by Formulae (A3):

  本发明涉及一种新型共聚酰亚胺前体，用于制备具有高透明度的聚酰亚胺。该共聚酰亚胺前体包括由通式（A1）表示的单元结构和由通式（A2）表示的单元结构：其中，在通式（A1）中，R1表示氢原子或具有1至4个碳原子的烷基基团；R2和R3各自独立地表示氢原子、具有1至6个碳原子的烷基基团或具有3至9个碳原子的烷基硅基团，在通式（A2）中，R4表示氢原子或具有1至4个碳原子的烷基基团；R5和R6各自独立地表示氢原子、具有1至6个碳原子的烷基基团或具有3至9个碳原子的烷基硅基团；X表示除通式（A3）所表示的四价基团以外的四价基团。