6,7-dimethoxy-2,3-di-2-thiophenylquinoxaline | 861883-42-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6,7-dimethoxy-2,3-di-2-thiophenylquinoxaline
• 英文别名: 6,7-Dimethoxy-2,3-di-thiophen-2-yl-quinoxaline；6,7-dimethoxy-2,3-dithiophen-2-ylquinoxaline
• CAS: 861883-42-3
• 化学式: C₁₈H₁₄N₂O₂S₂
• 分子量: 354.453
• InChiKey: QECWNBHGOWRVDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6,7-dimethoxy-2,3-di-2-thiophenylquinoxaline 在 sodium hydroxide 、 氢溴酸 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 6,7-Di-thiophen-2-yl-[1,3]dioxolo[4,5-g]quinoxaline
  参考文献：
  名称：

  Synthesis of selective SRPK-1 inhibitors: Novel tricyclic quinoxaline derivatives

  摘要：

  SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be active and selective for SRPK-1 kinase. Most of these novel compounds have drug-like properties according to experimentally determined Log P and Log S values. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.064
• 作为产物：
  描述：

  噻吩偶姻 、 1,2-二氨基-4,5-二甲氧基苯 以 乙醇 为溶剂， 反应 2.0h， 生成 6,7-dimethoxy-2,3-di-2-thiophenylquinoxaline
  参考文献：
  名称：

  Synthesis of selective SRPK-1 inhibitors: Novel tricyclic quinoxaline derivatives

  摘要：

  SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be active and selective for SRPK-1 kinase. Most of these novel compounds have drug-like properties according to experimentally determined Log P and Log S values. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.064

文献信息

• One-pot synthesis of quinoxalines from reductive coupling of 2-nitroanilines and 1,2-diketones using indium
  作者：Ahra Go、Geunsoo Lee、Jaeho Kim、Seolhee Bae、Byung Min Lee、Byeong Hyo Kim

  DOI：10.1016/j.tet.2015.01.007

  日期：2015.2

  reduction-cyclization of 2-nitroanilines and 1,2-diketones to give quinoxalines was investigated. Using indium and an appropriate acid such as acetic acid or indium(III) chloride, various quinoxaline derivatives including 2,3-dialkylquinoxalines, 2,3-diphenylquinoxalines, 2,3-di-2-thiophenylquinoxalines, 2,3-di(pyridin-2-yl)quinoxalines, and dibenzo[a,c]phenazines were synthesized in moderate to excellent

  研究了2-硝基苯胺和1,2-二酮的一锅还原环化反应生成喹喔啉。使用铟和适当的酸，例如乙酸或氯化铟（III），各种喹喔啉衍生物包括2,3-二烷基喹喔啉，2,3-二苯基喹喔啉，2,3-二-2-硫代苯基喹喔啉，2,3-二（吡啶） -2-基）喹喔啉和二苯并[ a，c ]吩嗪以中等至优异的产率合成。
• Synthesis of selective SRPK-1 inhibitors: Novel tricyclic quinoxaline derivatives
  作者：Zsolt Székelyhidi、János Pató、Frigyes Wáczek、Péter Bánhegyi、Bálint Hegymegi-Barakonyi、Dániel Ero˝s、György Mészáros、Ferenc Hollósy、Doris Hafenbradl、Sabine Obert、Bert Klebl、György Kéri、László O˝rfi

  DOI：10.1016/j.bmcl.2005.04.064

  日期：2005.7

  SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be active and selective for SRPK-1 kinase. Most of these novel compounds have drug-like properties according to experimentally determined Log P and Log S values. (c) 2005 Elsevier Ltd. All rights reserved.