4-Chloro-7,8-dimethoxyimidazo[1,5-a]quinoxaline | 221068-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-Chloro-7,8-dimethoxyimidazo[1,5-a]quinoxaline
• CAS: 221068-27-5
• 化学式: C₁₂H₁₀ClN₃O₂
• mdl: MFCD27414837
• 分子量: 263.683
• InChiKey: VMXKISSRMAEPLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  48.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-Chloro-7,8-dimethoxyimidazo[1,5-a]quinoxaline 在 三溴化硼 作用下， 以 四氢呋喃 为溶剂， 生成 N-(2-Chloro-6-methylphenyl)-7,8-dihydroxyimidazo[1,5-a]quinoxalin-4-amine
  参考文献：
  名称：

  Synthesis and SAR of novel imidazoquinoxaline-Based Lck inhibitors: improvement of cell potency

  摘要：

  A series of anilino(imidazoquinoxaline) analogues bearing solubilizing side chains at the 6- and 7-positions of the fused phenyl ring has been prepared and evaluated for inhibition against Lck enzyme and of T-cell proliferation. Significant improvement of the cellular activity was achieved over the initial lead, compound 2. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00677-7
• 作为产物：
  描述：

  1,2-二氨基-4,5-二甲氧基苯 在 三氟甲磺酸 、 sodium hydride 、 三氟乙酸 、 三氯氧磷 作用下， 以 四氢呋喃 、 苯甲醚 、 甲苯 为溶剂， 生成 4-Chloro-7,8-dimethoxyimidazo[1,5-a]quinoxaline
  参考文献：
  名称：

  Synthesis and SAR of novel imidazoquinoxaline-Based Lck inhibitors: improvement of cell potency

  摘要：

  A series of anilino(imidazoquinoxaline) analogues bearing solubilizing side chains at the 6- and 7-positions of the fused phenyl ring has been prepared and evaluated for inhibition against Lck enzyme and of T-cell proliferation. Significant improvement of the cellular activity was achieved over the initial lead, compound 2. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00677-7

文献信息

• Imidazoquinoxaline protein tyrosine kinase inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US06239133B1

  公开（公告）日：2001-05-29

  Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.

  本发明涉及新型咪唑并四氢喹喔啉化合物及其盐，含有这些化合物的药物组合物，以及使用这些化合物治疗蛋白酪氨酸激酶相关疾病，如免疫性疾病的方法。
• US6235740B1
  申请人：——

  公开号：US6235740B1

  公开（公告）日：2001-05-22
• US6239133B1
  申请人：——

  公开号：US6239133B1

  公开（公告）日：2001-05-29
• US6635626B1
  申请人：——

  公开号：US6635626B1

  公开（公告）日：2003-10-21
• Synthesis and SAR of novel imidazoquinoxaline-Based Lck inhibitors: improvement of cell potency
  作者：Ping Chen、Edwin J. Iwanowicz、Derek Norris、Henry H. Gu、James Lin、Robert V. Moquin、Jagabandhu Das、John Wityak、Steven H. Spergel、Henry de Fex、Suhong Pang、Sydney Pitt、Ding Ren Shen、Gary L. Schieven、Joel C. Barrish

  DOI：10.1016/s0960-894x(02)00677-7

  日期：2002.11

  A series of anilino(imidazoquinoxaline) analogues bearing solubilizing side chains at the 6- and 7-positions of the fused phenyl ring has been prepared and evaluated for inhibition against Lck enzyme and of T-cell proliferation. Significant improvement of the cellular activity was achieved over the initial lead, compound 2. (C) 2002 Elsevier Science Ltd. All rights reserved.