2-(Cyclohexoxy)-6-[(2,3-dimethyloxiran-2-yl)methyl]-3-methyl-pyrimidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(Cyclohexoxy)-6-[(2,3-dimethyloxiran-2-yl)methyl]-3-methyl-pyrimidin-4-one
• 英文别名: 2-cyclohexyloxy-6-[(2,3-dimethyloxiran-2-yl)methyl]-3-methylpyrimidin-4-one
• 化学式: C₁₆H₂₄N₂O₃
• 分子量: 292.378
• InChiKey: NCQTWYYWBHWKPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氯-2-丁酮 、 2-cyclohexyloxy-3,6-dimethyl-4(3H)-pyrimidinone 在 lithium diisopropyl amide 作用下， 生成 2-(Cyclohexoxy)-6-[(2,3-dimethyloxiran-2-yl)methyl]-3-methyl-pyrimidin-4-one
  参考文献：
  名称：

  A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives

  摘要：

  Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6-trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6methyl-4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1(Sendai) virus replication, (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00314-x

文献信息

• A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives
  作者：Raffaele Saladino、Maria Chiara Danti、Enrico Mincione、Claudia Crestini、Anna Teresa Palamara、Patrizia Savini、Stefano Marini、Maurizio Botta

  DOI：10.1016/s0960-894x(98)00314-x

  日期：1998.7

  Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6-trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6methyl-4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1(Sendai) virus replication, (C) 1998 Elsevier Science Ltd. All rights reserved.