2-(N-methyl-hydrazino)-aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(N-methyl-hydrazino)-aniline
• 英文别名: 2-(α-Methyl-hydrazino)-1-amino-benzol；2-(N-Methyl-hydrazino)-anilin；N-Methyl-N-(2-amino-phenyl)-hydrazin；1-(2-Amino-phenyl)-1-methyl-hydrazin；2-[Amino(methyl)amino]aniline
• 化学式: C₇H₁₁N₃
• mdl: MFCD19206795
• 分子量: 137.184
• InChiKey: LQMFMBGYAQXRRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  55.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(N-methyl-hydrazino)-aniline 在 磷酸酐 、 乙醚 作用下， 生成 1,2,4-苯并三嗪
  参考文献：
  名称：

  Hempel, Journal fur praktische Chemie (Leipzig 1954), 1890, vol. <2>41, p. 164

  摘要：

  DOI：
• 作为产物：
  描述：

  N-甲基-2-硝基苯胺 在 盐酸 、 ammonium sulfide 、 sodium nitrite 作用下， 生成 2-(N-methyl-hydrazino)-aniline
  参考文献：
  名称：

  Hempel, Journal fur praktische Chemie (Leipzig 1954), 1890, vol. <2>41, p. 164

  摘要：

  DOI：

文献信息

• [EN] PYRIDINE DERIVATIVES AND THEIR USE FOR TREATING HIV INFECTION<br/>[FR] DÉRIVÉS DE PYRIDINE ET LEUR UTILISATION POUR LE TRAITEMENT D'UNE INFECTION PAR LE VIH
  申请人：GILEAD SCIENCES INC

  公开号：WO2019161017A1

  公开（公告）日：2019-08-22

  The invention provides compounds having Formula (I): (I) or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

  该发明提供具有式（I）的化合物：（I）或其药学上可接受的盐，以及包含它们的药物组合物，其制备方法，以及通过它们的给药治疗和预防HIV感染的方法。
• PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF
  申请人：Shanghai Shaletech Technology Co., Ltd.

  公开号：EP3216786A1

  公开（公告）日：2017-09-13

  The present invention disclosed a class of pyrimidine or pyridine compounds, pharmaceutically acceptable salts, stereoisomers, prodrugs and solvates thereof, preparation method therefor and pharmaceutical compositions and pharmaceutical uses thereof. The compounds can inhibit the variants of EGFR (Epidermis Growth Factor Receptor) proteinases, and therefore can inhibit the growth of a variety of tumor cells effectively. The compounds can be used to prepare antitumor drugs, used for the treatment, combined therapy or prevention of various different cancers. The compounds can overcome the drug resistance induced by the existing first-generation EGFR inhibitors such as gefitinib, erlotinib and so on. Particularly, the compounds can be used to prepare drugs for treating or preventing diseases, disturbances, disorders or conditions mediated by epidermis growth factor receptor variants (such as L858R activated mutants, Exon19 deletion activated mutants and T790M resistant mutants).

  本发明公开了一类嘧啶或吡啶化合物、其药学上可接受的盐、立体异构体、原药和溶液、其制备方法和药物组合物及其药物用途。这些化合物可以抑制表皮生长因子受体蛋白酶的变体，从而有效抑制多种肿瘤细胞的生长。这些化合物可用于制备抗肿瘤药物，用于治疗、联合治疗或预防各种不同的癌症。这些化合物可以克服现有的第一代表皮生长因子受体抑制剂（如吉非替尼、厄洛替尼等）引起的耐药性。特别是，这些化合物可用于制备治疗或预防由表皮生长因子受体变体（如 L858R 激活突变体、Exon19 缺失激活突变体和 T790M 耐药突变体）介导的疾病、紊乱、失调或病症的药物。
• UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
  申请人：Ancureall Pharmaceutical (Shanghai) Co., Ltd.

  公开号：EP3424924A1

  公开（公告）日：2019-01-09

  Provided are a urea compound represented by general formula (I), a pharmaceutically acceptable salt thereof, a preparation method therefor, and use thereof as an FLT3 tyrosine protein kinase inhibitor, particularly in the prevention and/or treating of cancer.

  本发明提供了通式（I）代表的脲化合物、其药学上可接受的盐、其制备方法，以及其作为FLT3酪氨酸蛋白激酶抑制剂的用途，特别是在预防和/或治疗癌症中的用途。
• PHOSPHONATE ANALOGS OF HIV INHIBITOR COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：EP3539546A1

  公开（公告）日：2019-09-18

  The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗病毒抑制化合物、含有此类化合物的组合物、包括施用此类化合物的治疗方法，以及制备此类化合物的工艺和中间体。
• STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF
  申请人：Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

  公开号：EP3750908A1

  公开（公告）日：2020-12-16

  The present invention relates to steroid derivative regulators, a method for preparing the same, and uses thereof. Specifically, the present invention relates to a compound of formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and uses thereof as a regulator the of GABA A receptor for treating depression, convulsion, Parkinson's disease, and nervous system diseases, wherein the substituents of the formula (I) are as defined in the description.

  本发明涉及类固醇衍生物调节剂、其制备方法及其用途。具体而言，本发明涉及一种式（I）化合物、其制备方法、含有该化合物的药物组合物及其作为 GABA A 受体调节剂用于治疗抑郁症、抽搐、帕金森病和神经系统疾病的用途，其中式（I）的取代基如描述中所定义。