N-乙基-N-(4-氟苯基)-乙酰胺 | 388078-36-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-乙基-N-(4-氟苯基)-乙酰胺
• 英文名称: N-ethyl-N-(4-fluoro)acetamide
• 英文别名: Acetamide,N-ethyl-N-(4-fluorophenyl)-；N-ethyl-N-(4-fluorophenyl)acetamide
• CAS: 388078-36-2
• 化学式: C₁₀H₁₂FNO
• mdl: MFCD18823840
• 分子量: 181.21
• InChiKey: BOLCCBVSSKOAKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-乙基-N-(4-氟苯基)-乙酰胺 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 以94%的产率得到N,N-diethyl-4-methoxyaniline
  参考文献：
  名称：

  4-Fluoroanilines: synthesis and decomposition

  摘要：

  Fourteen N- and/or 2-substituted 4-fluoroanilines were prepared (the series includes N-C2-bridged compounds), Some of them were found to be thermally unstable when dissolved in chloroform. Both F-19 NMR spectra and comparison of GIAO-DFT calculated and experimental C-13 chemical shifts were used to suggest decomposition products of 4-fluoroanilines. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00401-8
• 作为产物：
  描述：

  4-氟乙酰苯胺 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 N-乙基-N-(4-氟苯基)-乙酰胺
  参考文献：
  名称：

  4-Fluoroanilines: synthesis and decomposition

  摘要：

  Fourteen N- and/or 2-substituted 4-fluoroanilines were prepared (the series includes N-C2-bridged compounds), Some of them were found to be thermally unstable when dissolved in chloroform. Both F-19 NMR spectra and comparison of GIAO-DFT calculated and experimental C-13 chemical shifts were used to suggest decomposition products of 4-fluoroanilines. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00401-8

文献信息

• Electrophilic Amination with Nitroarenes
  作者：Marian Rauser、Christoph Ascheberg、Meike Niggemann

  DOI：10.1002/anie.201705356

  日期：2017.9.11

  Nitro-Power! An exceptionally general electrophilic amination of zinc organyl compounds was developed, and yields alkylated aromatic aminoboranes from commercially available nitroarenes. The partially reduced nitro group is directly engaged as an electrophilic nitrogen intermediate. The aminoboranes were reacted with electrophiles, thereby incorporating two different substituents at the N atom of the

  硝基动力！开发了一种特别普遍的锌有机基化合物的亲电胺化反应，并从市售硝基芳烃中得到烷基化的芳族氨基硼烷。部分还原的硝基直接作为亲电子氮中间体参与。使氨基硼烷与亲电试剂反应，从而以一锅法在前硝基的N原子处引入两个不同的取代基。
• [EN] MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF<br/>[FR] DÉRIVÉS DE PYRIDONE MULTISUBSTITUÉS ET LEUR UTILISATION MÉDICALE<br/>[ZH] 多取代吡啶酮类衍生物及其在医药上的应用
  申请人：BEIJING YUEZHIKANGTAI BIOMEDICINES CO LTD

  公开号：WO2020042618A1

  公开（公告）日：2020-03-05

  公开了多取代吡啶酮类衍生物及其在医药上的应用。特别地，公开了涉及通式(I)所示的化合物、其制备方法及含有该化合物的药物组合物，及其用作酪氨酸激酶抑制剂的用途，特别是用于治疗与酪氨酸激酶活性相关的疾病的用途。其中通式(I)中的各取代基的定义与说明书中的定义相同。
• BICYCLIC COMPOUNDS AND COMPOSITIONS AS PDF INHIBITORS
  申请人：IRM, LLC

  公开号：EP1651643A2

  公开（公告）日：2006-05-03
• EP1651643A4
  申请人：——

  公开号：EP1651643A4

  公开（公告）日：2008-10-08
• [EN] BICYCLIC COMPOUNDS AND COMPOSITIONS AS PDF INHIBITORS<br/>[FR] COMPOSES BICYCLIQUES ET COMPOSITIONS UTILISEES COMME INHIBITEURS PDF
  申请人：IRM LLC

  公开号：WO2005011611A2

  公开（公告）日：2005-02-10

  This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.