4-(4-羟基丁基氨基)-1-丁醇 | 79448-06-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-(4-羟基丁基氨基)-1-丁醇
• 英文名称: 4,4’-azanediylbis(butan-1-ol)
• 英文别名: 4,4'-azanediylbis(butan-1-ol)；dibutanolamine；bis-(4-hydroxy-butyl)-amine；Bis-(4-hydroxy-butyl)-amin；4.4'-Dihydroxy-dibutylamin；bis(4-hydroxybutyl)amine；4-(4-Hydroxybutylamino)butan-1-ol
• CAS: 79448-06-9
• 化学式: C₈H₁₉NO₂
• 分子量: 161.244
• InChiKey: FTGIHCSSXPBYMX-UHFFFAOYSA-N

物化性质

• 熔点：
  16-17℃
• 沸点：
  240-250℃
• 密度：
  0.9809 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  4-(4-羟基丁基氨基)-1-丁醇 在 吡啶 、 aluminum oxide 作用下， 生成 1-(3-丁烯基)吡咯烷
  参考文献：
  名称：

  Glacet; Deram, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1954, vol. 239, p. 889

  摘要：

  DOI：
• 作为产物：
  描述：

  4-((4-((tetrahydro-2H-pyran-2-yl)oxy)butyl)amino)butan-1-ol 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 生成 4-(4-羟基丁基氨基)-1-丁醇
  参考文献：
  名称：

  Synthesis of reduced collagen crosslinks

  摘要：

  A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00252-8

文献信息

• [EN] CATALYTIC PREPARATION OF SEVERELY STERICALLY HINDERED AMINO-ETHER ALCOHOLS USING A METAL LOADED CATALYST<br/>[FR] PREPARATION CATALYTIQUE D'ALCOOLS AMINO-ETHER A ENCOMBREMENT STERIQUE SEVERE UTILISANT UN CATALYSEUR A CHARGE METALLIQUE
  申请人：EXXONMOBIL RES & ENG CO

  公开号：WO2005082834A1

  公开（公告）日：2005-09-09

  The present invention relates to a process for the production of severely sterically hindered amino-ether alcohols using a catalyst based on the combination of one or more catalytically active metals supported in a dispersed form on one or more ordered mesoporous materials as support.

  本发明涉及一种利用基于一个或多个催化活性金属的组合在一个或多个有序介孔材料上以分散形式支撑的催化剂的过程，用于生产严重立体位阻的氨基醚醇。
• FUNCTIONALIZED MONOMERS AND POLYMERS
  申请人：DiBiase Stephen Augustine

  公开号：US20120245063A1

  公开（公告）日：2012-09-27

  This invention relates to a composition, comprising: an unsaturated functionalized monomer of from about 5 to about 30 carbon atoms, which is: (a) polymerized to form a functionalized polymer; (b) copolymerized with a comonomer to form a functionalized copolymer; or (c) reacted with an enophilic reagent to form a polyfunctionalized monomer. The polyfunctionalized monomer may be polymerized to form a polyfunctionalized polymer which may be further reacted with one or more additional reagents. The invention relates to lubricants, functional fluids, fuels, dispersants, detergents and polymeric resins.

  这项发明涉及一种组合物，包括：一个由约5至约30个碳原子的不饱和官能化单体组成，该单体：(a)聚合形成官能化聚合物；(b)与共聚单体共聚形成官能化共聚物；或(c)与亲亚烯试剂反应形成多官能单体。多官能单体可以聚合形成多官能聚合物，该聚合物可以进一步与一个或多个额外试剂反应。该发明涉及润滑剂、功能流体、燃料、分散剂、清洁剂和聚合树脂。
• Room-temperature Pd-catalyzed methoxycarbonylation of terminal alkynes with high branched selectivity enabled by bisphosphine-picolinamide ligand
  作者：Ding Liu、Miaolin Ke、Tong Ru、Yingtang Ning、Fen-Er Chen

  DOI：10.1039/d1cc06098h

  日期：——

  The challenging room temperature Pd-catalyzed methoxycarbonylation for a wide array of alkynes with excellent branched selectivity has been developed.

  已开发出具有出色支链选择性的广泛烯烃室温Pd催化的甲氧羰基化反应。
• The total synthesis of <b>(<scp>−</scp>)</b>-strempeliopine <i>via</i> palladium-catalyzed decarboxylative asymmetric allylic alkylation
  作者：Yi An、Mengjuan Wu、Weijian Li、Yaling Li、Zhenzhen Wang、Yansong Xue、Pei Tang、Fener Chen

  DOI：10.1039/d1cc06278f

  日期：——

  In the work reported herein, the concise and enantioselective total synthesis of the Schizozygine alkaloid (−)-strempeliopine was developed. This synthetic strategy featured the palladium-catalyzed decarboxylative asymmetric allylic alkylation of N-benzoyl lactam to set up the absolute configuration at the C20 position, a highly diastereoselective one-pot Bischler–Napieralski/lactamization and iminium

  在本文报道的工作中，开发了Schizozygine生物碱 (-)-strempeliopine的简明和对映选择性全合成。该合成策略的特点是钯催化的N-苯甲酰基内酰胺的脱羧不对称烯丙基烷基化在 C20 位建立绝对构型，高度非对映选择性的一锅 Bischler-Napieralski/内酰胺化和亚胺还原序列用于构建五环核心结构，以及吲哚的后期去芳烃添加，导致难以实现的具有完全控制四个相邻立体中心的六环二氢吲哚框架。
• GLUCOSE-RESPONSIVE INSULIN CONJUGATES
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150105317A1

  公开（公告）日：2015-04-16

  Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

  本发明涉及胰岛素共轭物，包括将胰岛素分子共价连接至至少一个双齿配体的连接物中，每个配体独立连接到包含一种含糖和其中至少一个连接物的配体的糖类，其中连接物的至少一个配体的糖类为岩藻糖。这些胰岛素共轭物展示出对系统浓度的糖类（如葡萄糖或α-甲基甘露糖）具有响应的药代动力学（PK）和/或药效动力学（PD）特性，即使在给予需要的受试者时，也不需要外源多价糖类结合分子（如Con A）。