2-[2-(2-Hydroxyethoxy)propyl]-1,3-dioxolane | 96424-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: 2-[2-(2-Hydroxyethoxy)propyl]-1,3-dioxolane
• 英文别名: 2-[1-(1,3-dioxolan-2-yl)propan-2-yloxy]ethanol
• CAS: 96424-50-9
• 化学式: C₈H₁₆O₄
• 分子量: 176.213
• InChiKey: SOELUYOWIYHLKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[2-(2-Hydroxyethoxy)propyl]-1,3-dioxolane 在 三甲基氯硅烷 、 硫酸 、 四氯化锡 、 六甲基二硅氮烷 作用下， 以 乙腈 为溶剂， 反应 165.25h， 生成 (1'R*,3'S*)-1-<<3-(2-hydroxyethoxy)-1-isopropoxy>butyl>-5-fluorouracil
  参考文献：
  名称：

  5-氟尿嘧啶衍生物。1.无环核苷通过氯化锡（IV）介导的烷氧基-1,4-二杂庚烷的区域特异性开环

  摘要：

  5-氟尿嘧啶在室温下在氯化锡（IV），三甲基氯硅烷和六甲基二硅氮烷的存在下与七元缩醛1a-g反应，得到1-{[[3-（2-（羟乙基杂）-1-烷氧基]烷基] -5-氟尿嘧啶2A-F和1 - {[2-（3-羟基丙氧基）-1-异丙氧基]乙基} -5-氟尿嘧啶2克在31-86％的产率。杂原子在环缩醛的1位上的存在和氯化锡（IV）能够进行1,4-螯合，似乎在1a-g的区域特异性开环中施加了它们的影响。对2b和（1 R，3 R）-2e和（1 R，3S）-2e清楚地表明，N 1（sp 2）-C 1 -C 2 -C 3部分倾向于以薄纱构象折叠。评估化合物2b-g对HEp人类细胞的抗肿瘤活性，显示2c的活性是5-FU的4倍。与5-FU的毒性作用相比，所研究的药物未显示任何明显的毒性。

  DOI：

  10.1016/0040-4020(96)00439-5
• 作为产物：
  描述：

  巴豆醛 、 乙二醇 以50%的产率得到
  参考文献：
  名称：

  SOLAREK, DANIEL B.;JOBE, PATRICK G.;TESSLER, MARTIN M.;BIILMERS, ROBERT L+

  摘要：

  DOI：

文献信息

• Acetalization of α,β-unsaturated carbonyl compounds catalyzed by complexes of Pt(II)
  作者：Enrico Nieddu、Maurizio Cataldo、Francesco Pinna、Giorgio Strukul

  DOI：10.1016/s0040-4039(99)01419-7

  日期：1999.9

  sufficiently Lewis acidic to catalyze the acetalization of aldehydes and ketones. α,β-Unsaturated substrates can be easily acetalized with ethylene glycol under mild conditions in high yield and avoiding side reactions leading to formation of undesired by-products arising from the nucleophilic addition to the carboncarbon double bond conjugated to the carbonyl group. A comparison of the behavior of a Pt

  一类Pt（II）的阳离子二膦配合物具有足够的路易斯酸性，可以催化醛和酮的缩醛化。α，β-不饱和底物可以在温和的条件下容易地用乙二醇缩醛化，收率很高，并且避免了副反应，该副反应导致形成不希望的副产物，该副产物是由与羰基共轭的碳碳双键的亲核加成而形成的。在相同条件下，Pt络合物相对于PTSA作为催化剂的行为比较表明，在许多情况下，前者具有优越的选择性。
• A New Systematization of the Conformational Behavior of Seven-Membered Rings. Isoclinal Anomeric and Related Orientations¹
  作者：A. Entrena、J. Campos、J. A. Gómez、M. A. Gallo、A. Espinosa

  DOI：10.1021/jo951950j

  日期：1997.1.1

  The chair and twist-chair conformations of seven-membered rings are classified as a function of the signs of their endocyclic torsion angles. The conformational analysis (MM3) of the methoxy- and methyloxepanes 1-6 used as patterns allows the study and classification of the different types of hydrogen orientation in the seven-membered saturated heterocycles. General principles are established, allowing

  七元环的椅子和扭曲椅子构型根据其内环扭转角的符号进行分类。用作模式的甲氧基和甲基氧杂环丁烷1-6的构象分析（MM3）可以研究和分类七元饱和杂环中不同类型的氢取向。建立了一般原理，从而可以根据取代基类型，其在环中的位置以及已被取代的氢原子的类型来预测不同扭转椅构象的稳定性。这些结果扩展到1，4-二氧戊环衍生物7-13，并与实验数据进行比较。
• Acetals and ethers-xiii Reaction products of 2-butenal with ethylene glycol
  作者：Andrzej Piasecki

  DOI：10.1016/s0040-4020(01)91323-7

  日期：1984.1

  The unsaturated cyclic acetal, 2-(1-propenyl)-1,3-dioxolane (2), has been found as an intermediate product in the p-toluenesulfonic acid catalysed reaction of 2-butenal with an excess of ethylene glycol. The final product consisted of 2-[2-(2-hydroxyethoxy)-propyl]-1,3-dioxolane (3), and a small amount of geometric isomers of cis- and trans-5-(2-hydroxyethoxy)-7-methyl-1,4-dioxepane (4a and 4b, respectively)

  已发现不饱和环状环状缩醛2-（1-丙烯基）-1，3-二氧戊环（2）是对甲苯磺酸催化的2-丁烯醛与过量乙二醇反应的中间产物。最终产物由2- [2-（2-羟基乙氧基）-丙基] -1,3-二氧戊环（3）以及少量顺式和反式-5-（2-羟基乙氧基）-7的几何异构体组成-甲基-1,4-二氧戊环（分别为4a和4b）。
• Polysaccharide derivatives containing aldehyde groups, their preparation
  申请人：National Starch and Chemical Corporation

  公开号：US04741804A1

  公开（公告）日：1988-05-03

  Polysaccharide aldehydes having the formula ##STR1## starch, cellulose, and gum aldehydes, are useful for imparting wet, dry, or temporary wet strength to paper. They are prepared by a non-oxidative method which involves reacting the polysaccharide base, in the presence of alkali, with a derivatizing acetal reagent having the general structure ##STR2## and then hydrolyzing the acetal by adjusting the pH to less than 7, preferably 2-4. In the formula, n is 1-3; R.sup.11 and R.sup.12 are independently an alkyl, aryl, aralkyl, or alkaryl group when n is 1, R.sup.11 or R.sup.12 is one of the groups when n is 2, or R.sup.11 and R.sup.12 are not present when n is 3; R.sup.13 is an alkyl group, optionally containing an ether linkage, or an aryl, aralkyl, or alkaryl group; R.sup.14 and R.sup.15 are individually a hydrogen or a methyl group; R.sup.16, R.sup.17, and R.sup.18 are individually an alkyl group; Y.sup.- is an anion; Z is an organic group capable of reacting with the polysaccharide base to form an ether derivative and selected from the group consisting of an epoxide, ethylenically unsaturated group, halohydrin, and halogen; R.sup.19, if present, is a divalent organic group containing no reactive substituents; and A and A' are lower alkyls or together form at least a 5-membered cyclic acetal.

  具有以下结构式##STR1##的多糖醛，包括淀粉、纤维素和胶醛，可用于给纸张赋予湿强度、干强度或临时湿强度。它们是通过非氧化方法制备的，该方法涉及在碱性条件下，用具有一般结构式##STR2##的衍生乙缩醛试剂与多糖基反应，然后通过将pH调整为小于7（最好为2-4）水解缩醛而制备的。在上述结构式中，n是1-3；R.sup.11和R.sup.12分别是烷基、芳基、芳烷基或烷芳基，当n为1时，R.sup.11或R.sup.12是其中之一，当n为2时，R.sup.11和R.sup.12中有一个，当n为3时，R.sup.11和R.sup.12不存在；R.sup.13是烷基，可选地含有醚键，或者是芳基、芳烷基或烷芳基；R.sup.14和R.sup.15分别是氢或甲基基团；R.sup.16、R.sup.17和R.sup.18分别是烷基；Y.sup.-是阴离子；Z是有机基团，能够与多糖基反应形成醚衍生物，并从以下群组中选择：环氧化物，乙烯基不饱和基团，卤代水合物和卤素；如果存在，则R.sup.19是不含反应性取代基的二价有机基团；A和A'是较低的烷基，或者一起形成至少5个成员的环缩醛。
• Polysaccharide graft polymers containing acetal groups and their
  申请人：National Starch and Chemical Corporation

  公开号：US04866151A1

  公开（公告）日：1989-09-12

  Polysaccharide graft polymers which comprise an acetal-containing or aldehyde-containing homopolymer or copolymer grafted to a polysaccharide base have been prepared. The monomer repeating units in the homopolymer are derived from one or more ethylenically or allylically unsaturated monomers containing an acetal group or aldehyde group; The monomer repeating units in the copolymer are derived from the above monomer and derived from one or more ethylenically or allylically unsaturated monomers other than the acetal-containing or aldehyde-containing monomer. A and A' are independently a lower alkyl or A and A' together form at least a 5-membered cyclic acetal; with the proviso that the graft polymer contain no ##STR1## groups when the aldehyde groups are present. The aldehyde-containing graft polymers are useful for imparting wet strength to paper. Various novel acetal- and aldehyde-containing monomers have also been prepared; they can be graft polymerized to polysaccharide substrates or polymerized by conventional emulsion polymerization techniques with vinyl polymerizable monomers.

  已经制备出了包含缩醛基或醛基的同聚物或共聚物嫁接到多糖基底上的多糖嫁接聚合物。同聚物中的单体重复单元来自于一个或多个含有缩醛基或醛基的乙烯基或烯丙基不饱和单体；共聚物中的单体重复单元来自于上述单体和来自于一个或多个不含缩醛基或醛基单体的乙烯基或烯丙基不饱和单体。A和A'分别是较低的烷基或A和A'一起形成至少一个5元环缩醛基；但是嫁接聚合物在存在醛基时不包含##STR1##基团。含有醛基的嫁接聚合物对于赋予纸张湿强度很有用。还制备了各种新型含缩醛基和醛基的单体；它们可以嫁接聚合到多糖基底上或通过常规乳液聚合技术与乙烯基可聚合单体共聚合。