3,4-呋喃二甲酸 | 3387-26-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 中文名称: 3,4-呋喃二甲酸
• 英文名称: furan-3,4-dicarboxylic acid
• 英文别名: furan 3,4 dicarboxylic acid；3,4-furandicarboxylic acid；3,4-Furandicarbonsaeure；FDC；Furan-3,4-dicarbonsaeure；3,4-Furan-dicarbonsaeure
• CAS: 3387-26-6
• 化学式: C₆H₄O₅
• mdl: MFCD00022465
• 分子量: 156.095
• InChiKey: SYLAFCZSYRXBJF-UHFFFAOYSA-N

物化性质

• 熔点：
  217-218 °C
• 沸点：
  372.6±27.0 °C(Predicted)
• 密度：
  1.604±0.06 g/cm3(Predicted)
• LogP：
  0.263 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.7
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险品标志：
  C
• 海关编码：
  2932190090
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

Name:	3 4-Furandicarboxylic Acid 99% Material Safety Data Sheet
Synonym:	None known
CAS:	3387-26-6

Section 1 - Chemical Product MSDS Name:3 4-Furandicarboxylic Acid 99% Material Safety Data Sheet
Synonym:None known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
3387-26-6	3,4-Furandicarboxylic Acid	99	222-210-3

Hazard Symbols: C
Risk Phrases: 34

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin burns. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May cause systemic effects.
Inhalation:
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Causes chemical burns to the respiratory tract. The toxicological properties of this substance have not been fully investigated.
Aspiration may lead to pulmonary edema. May cause systemic effects.
Chronic:
Effects may be delayed.

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Section 4 - FIRST AID MEASURES
Eyes: Get medical aid. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Keep container tightly closed. Avoid ingestion and inhalation. Discard contaminated shoes.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 3387-26-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: almost white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 212.00 - 214.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H4O5
Molecular Weight: 156.09

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 3387-26-6 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
3,4-Furandicarboxylic Acid - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE SOLID, N.O.S.*
Hazard Class: 8
UN Number: 1759
Packing Group: III
IMO
Shipping Name: CORROSIVE SOLID, N.O.S.
Hazard Class: 8
UN Number: 1759
Packing Group: III
RID/ADR
Shipping Name: CORROSIVE SOLID, N.O.S.
Hazard Class: 8
UN Number: 1759
Packing group: III

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 3387-26-6: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 3387-26-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 3387-26-6 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3,4-呋喃二甲酸 在 喹啉 、 铜 作用下， 生成 3-糠酸
  参考文献：
  名称：

  呋喃多元羧酸

  摘要：

  DOI：

  10.1002/hlca.19330160138
• 作为产物：
  描述：

  tetraethyl furan-2,3,4,5-tetracarboxylate 在 氢氧化钾 作用下， 生成 3,4-呋喃二甲酸
  参考文献：
  名称：

  呋喃多元羧酸

  摘要：

  DOI：

  10.1002/hlca.19330160138

文献信息

• Novel amino acid ester and reagent composition for detecting leucocytes or elastase in body liquid
  申请人：KYOTO DAIICHI KAGAKU CO., LTD.

  公开号：EP0661280A1

  公开（公告）日：1995-07-05

  An amino acid ester of the formula: (X-O-A-)n-Y in which X is derived from an aromatic or heterocyclic compound: X-OH or its derivative; A is a residue of a L-amino acid, n is an integer of at least 2, and Y is a N-substituent of an amino acid derived from a compound having the same or different two or more carbonyl or sulfonyl groups which is formed from a single or complex compound selected from the group consisting of noncyclic or cyclic hydrocarbons having 1 to 10 carbon atoms, saturated or unsaturated heterocyclic compounds, aromatic compounds, organosilicon compounds having 1 to 10 silicon atoms, monosaccharides and oligosaccharide comprising 2 to 10 monosaccharides, all of which may have a substituent and/or a hetero atom to form the complex, which ester is specifically hydrolyzed by leucocytes or elastase.

  公式为(X-O-A-)n-Y的氨基酸酯，其中X源自芳香族或杂环化合物：X-OH或其衍生物；A是L-氨基酸的残基，n是至少为2的整数，Y是源自具有相同或不同的两个或更多个羰基或磺酰基的化合物的氨基酸的N-取代基，该化合物由选择自非环烃或环烃的群组成的单一或复杂化合物形成，该群包括具有1至10个碳原子的饱和或不饱和杂环化合物、芳香族化合物、具有1至10个硅原子的有机硅化合物、由2至10个单糖组成的单糖和寡糖，所有这些化合物均可具有取代基和/或杂原子以形成复合物，该酯特异地被白细胞或弹性蛋白酶水解。
• Pd-catalyzed direct C–H arylation of thieno[3,4-c]pyrrole-4,6-dione (TPD): a step-economical synthetic alternative to access TPD-centred symmetrical small molecules
  作者：Shan-Yun Chang、Po-Han Lin、Ching-Yuan Liu

  DOI：10.1039/c4ra05380j

  日期：——

  to access a series of thieno[3,4-c]pyrrole-4,6-dione (TPD)-based π-conjugated molecules through Pd-catalyzed direct C–H arylations. A comprehensive synthetic study including the screening of various kinds of palladium catalysts, ligands, and bases is reported. Under the optimum reaction conditions, TPD and its common derivatives underwent efficient and mild direct C–H arylations with a variety of functionalized

  我们演示了通过Pd催化的直接C–H芳基化来访问一系列基于噻吩并[3,4- c ]吡咯-4,6-二酮（TPD）的π-共轭分子的分步经济实用的替代方法。据报道，一项综合的综合研究包括对各种钯催化剂，配体和碱的筛选。在最佳反应条件下，TPD及其常见衍生物通过各种官能化的溴代芳烃进行了高效温和的直接C–H芳基化反应。酯，腈，酮，醛和卤化物等官能团具有良好的耐受性，从而大大扩展了反应范围。我们希望所报道的方法将为材料科学家提供一种相对绿色的合成途径，以有效地制备含TPD的π功能材料。
• [EN] OPTICAL DATA COMMUNICATION SYSTEM COMPRISING PARA-PHENYLENEVINYLENES AND SPECIFIC PARA-PHENYLENEVINYLENES<br/>[FR] SYSTÈME DE COMMUNICATION DE DONNÉES OPTIQUES COMPRENANT DES PARA-PHÉNYLÈNEVINYLÈNES ET DES PARA-PHÉNYLÈNEVINYLÈNES SPÉCIFIQUES
  申请人：BASF SE

  公开号：WO2019238532A1

  公开（公告）日：2019-12-19

  An optical data communication system comprising para-phenylenevinylenes, a receiver for an optical data communication system comprising para-phenylenevinylenes, a transmitter for an optical data communication system comprising para-phenylenevinylenes, the use of para- phenylenevinylenes in an optical data communication system, specific para-phenylenevinylenes and their preparation.

  一种包括对苯二乙烯的光数据通信系统，一种包括对苯二乙烯的光数据通信系统的接收器，一种包括对苯二乙烯的光数据通信系统的发射器，对苯二乙烯在光数据通信系统中的使用，特定对苯二乙烯及其制备。
• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS
  申请人：Chodorowski-Kimmes Sandrine

  公开号：US20100239509A1

  公开（公告）日：2010-09-23

  The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups; of a monocarboxylic acid containing 6 to 32 carbon atoms; of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and (b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

  本专利申请涉及一种化妆品或皮肤科学组合物，包括在化妆品或皮肤科学上可接受的介质中，包含以下聚合物的组合物：(a) 由以下反应得到的聚合物骨架：含有3至6个羟基的多元醇；含有6至32个碳原子的一元羧酸；至少含有两个羧基COOH的多元羧酸，和/或类似多元羧酸的环酐和/或至少含有一个羧基COOH的内酯；以及(b) 至少一个连接到所述聚合物骨架的连接基团，并能够与一个或多个配对连接基团建立H键，每个连接基团的配对涉及至少三个H（氢）键。该专利申请还涉及使用所述组合物的化妆品处理过程。
• COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION
  申请人：GIUSTINIANI Pascal

  公开号：US20090028807A1

  公开（公告）日：2009-01-29

  The present application relates to a cosmetic or pharmaceutical, in particular lipstick, composition comprising a polycondensate The application also relates to a method of cosmetic treatment using the composition, the polycondensate thus defined and a method of preparing the polycondensate.

  本申请涉及一种化妆品或药用品，特别是口红，包括聚缩酸酯的组合物。该申请还涉及一种使用该组合物进行化妆处理的方法，所述聚缩酸酯的定义以及一种制备聚缩酸酯的方法。