4-(4-Chloro-2-hydroxybutoxy)benzamide | 116290-70-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-Chloro-2-hydroxybutoxy)benzamide
• CAS: 116290-70-1
• 化学式: C₁₁H₁₄ClNO₃
• 分子量: 243.69
• InChiKey: DLKUYWYJQFIDMA-UHFFFAOYSA-N

物化性质

• 熔点：
  150-153 °C
• 沸点：
  477.2±35.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-Chloro-2-hydroxybutoxy)benzamide 生成 1-(4-aminocarbonylphenoxy)-4-(4-phenylpiperazino)-2-butanol
  参考文献：
  名称：

  WALSH, DAVID A.;YANNI, JOHN M.

  摘要：

  DOI：
• 作为产物：
  描述：

  1,4-二氯-2-丁醇 生成 4-(4-Chloro-2-hydroxybutoxy)benzamide
  参考文献：
  名称：

  WALSH, DAVID A.;YANNI, JOHN M.

  摘要：

  DOI：

文献信息

• 1-aryloxy-4-amino-2-butanols
  申请人：A. H. Robins Company, Incorporated

  公开号：US04806555A1

  公开（公告）日：1989-02-21

  Novel 1-aryloxy-4-amino-2-butanols of the formula ArO--CH.sub.2 --CHOH--CH.sub.2 --CH.sub.2 --NR.sup.1 R.sup.2 wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R.sup.1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymethyl-2-propyl, adamantyl or lower-cycloalkyl, R.sup.2 is hydrogen or lower alkyl, wherein R.sup.1 and R.sup.2 together with the adjacent nitrogen from a heterocyclic residue and the pharmaceutically acceptable acid addition salts thereof having local anesthetic, beta-adrenergic blocking, antihypertensive and antiarrhythmic properties are disclosed. The compounds are prepared by reacting novel 1-aryloxy-4-chloro-2-butanols with amines. Methods for the preparation of the novel 1-aryloxy-4-chloro-2-butanol intermediates are also disclosed.

  化合物的名称为Novel 1-aryloxy-4-amino-2-butanols，化学式为ArO--CH.sub.2 --CHOH--CH.sub.2 --CH.sub.2 --NR.sup.1 R.sup.2，其中Ar可以是1-萘基、2-萘基、茚-4（或5-）基、3-（或5-）氯基-2-吡啶基、苯基、单取代苯基或二取代苯基，R.sup.1可以是较低的烷基、苯基、苯基烷基、2-羟甲基-2-丙基、金刚烷基或较低的环烷基，R.sup.2可以是氢或较低的烷基。这些化合物与相邻氮原子组成杂环残基，并且它们的药物可接受的酸盐具有局部麻醉、β-肾上腺素受体阻滞、降压和抗心律失常的性质。这些化合物是通过将新型的1-芳氧基-4-氯-2-丁醇与胺反应制备而成的。此外，还公开了制备新型1-芳氧基-4-氯-2-丁醇中间体的方法。
• 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy
  申请人：A. H. Robins Company, Incorporated

  公开号：US04882330A1

  公开（公告）日：1989-11-21

  1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols of the formula: ##STR1## wherein Ar is selected fro ##STR2## or 2, 3 or 4-pyridyl); X and X' are selected from the group of hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, nitro, acetylamino, phenyl or ##STR3## acetyl, cyano, aminocarbonyl, carboxy, or loweralkyl carboxylic acid ester; Y, Y', Y" are selected from the same group as X and X' except phenyl and substituted phenyl are excluded; Z and Z' are selected from hydrogen, loweralkyl or loweralkoxy and the pharmaceutically acceptable salt thereof are employed in a method of inhibiting or combatting allergic response associated with anaphylactic sensitivity in animals and humans.

  该公式是1-芳氧基-4-[(4-芳基)-1-哌嗪基]-2-丁醇，其中Ar从以下组合中选择##STR2##或2,3或4-吡啶基）; X和X'从氢，低烷基，低烷氧基，卤素，三氟甲基，硝基，乙酰氨基，苯基或##STR3##乙酰，氰基，氨基甲酰，羧基或低烷基羧酸酯中选择; Y，Y'，Y"从与X和X'相同的组合中选择，但排除了苯基和取代苯基; Z和Z'从氢，低烷基或低烷氧基中选择，以及其药学上可接受的盐，用于抑制或对抗动物和人类的过敏反应，与过敏性反应相关的过敏性敏感性。
• 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
  申请人：A.H. ROBINS COMPANY, INCORPORATED

  公开号：EP0269383A2

  公开（公告）日：1988-06-01

  1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols of the formula: wherein Ar is selected from or 2, 3 or 4-pyridyl); X and Xʹ are selected from the group of hydrogen, loweralkyl, loweralkoxy, halogen, tri­fluoromethyl, nitro, acetylamino, phenyl or acetyl, cyano, aminocarbonyl, carboxy, or loweralkyl carboxylic acid ester; Y, Yʹ, Yʺ and Xʺ are selected from the same group as X and Xʹ except phenyl and substituted phenyl are excluded; Z and Zʹ are selected from hydrogen, loweralkyl or loweralkoxy and the pharmaceutically acceptable salt thereof are useful in inhibiting or combatting allergic response associated with anaphylactic sensitivity in animals and humans.

  式中的 1-芳氧基-4-[(4-芳基)-1-哌嗪基]-2-丁醇： 其中 Ar 选自 或 2、3 或 4-吡啶基）； X 和 Xʹ 选自氢、低级烷基、低级烷氧基、卤素、三氟甲基、硝基、乙酰氨基、苯基或 Y、Yʹ、Yʺ和 Xʺ选自与 X 和 Xʹ相同的组，但不包括苯基和取代苯基；Z 和 Zʹ选自氢、低级烷基或低级烷氧基及其药学上可接受的盐，可用于抑制或对抗动物和人类与过敏反应相关的过敏反应。
• The synthesis and antiallergy activity of 1-(aryloxy)-4-(4-arylpiperazinyl)-2-butanol derivatives
  作者：David A. Walsh、Ying Ho Chen、Jerry B. Green、Joseph C. Nolan、John M. Yanni

  DOI：10.1021/jm00168a044

  日期：1990.6

  A series of 1-(aryloxy)-4-(4-arylpiperazinyl)-2-butanol derivatives were prepared and evaluated for antiallergy activity in the passive foot anaphylaxis (PFA) assay in rats. Twenty-seven derivatives had activity equal to or greater than the parent, alpha-(phenoxymethyl)-4-phenyl-1-piperazinepropanol. Six derivatives that possessed greater activity in the PFA than the parent compound were then tested in the guinea pig anaphylaxis (GPA) assay. Five of the derivatives were more potent than the parent (PD50 = 40 mg/kg) in the GPA with alpha-[(4-fluorophenoxy)methyl]-4-(4-fluorophenyl)-1-piperazinepropan ol (PD50 = 3 mg/kg) having the greatest potency.
• LUNSFORID, CARL D.;CHEN, YING-HO
  作者：LUNSFORID, CARL D.、CHEN, YING-HO

  DOI：——

  日期：——