2-(thiophen-2-yl)-N-(o-tolyl)acetamide | 69047-43-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(thiophen-2-yl)-N-(o-tolyl)acetamide
• 英文别名: N-(2-methylphenyl)-2-(2-thienyl)acetamide；N-(2-methylphenyl)-2-thiophen-2-ylacetamide
• CAS: 69047-43-4
• 化学式: C₁₃H₁₃NOS
• mdl: MFCD01269132
• 分子量: 231.318
• InChiKey: AOLHVEOEGDVOKY-UHFFFAOYSA-N

物化性质

• 溶解度：
  >34.7 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  57.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  bis(2-oxo-1,3-oxazolidin-3-yl)phosphoryl 2-thiophen-2-ylacetate 生成 2-(thiophen-2-yl)-N-(o-tolyl)acetamide
  参考文献：
  名称：

  DIAGO-MESEGUER J.; PALOMO-COLL A. L.; FERNANDEZ-LIZARBE J. R.; ZUGARA-BIL+, SYNTHESIS, 1980, NO 7, 547-551

  摘要：

  DOI：

文献信息

• Late-Stage Diversification of Biarylphosphines through Rhodium(I)-Catalyzed C–H Bond Alkenylation with Internal Alkynes
  作者：Zhuan Zhang、Marie Cordier、Pierre H. Dixneuf、Jean-François Soulé

  DOI：10.1021/acs.orglett.0c02023

  日期：2020.8.7

  We report herein P(III)-directed C–H bond alkenylation of (dialkyl)- and (diaryl)biarylphosphines using internal alkynes. Chloride-free [Rh(OAc)(COD)]2 acts as a better catalyst than commercially available [RhCl(COD)]2. Conditions were developed to control the mono- and difunctionalization depending on the alkyne stoichiometry. One of these novel bisalkenylated (dialkyl)biarylphosphines was employed

  我们在此报告使用内部炔烃的（二烷基）-和（二芳基）联芳基膦的P（III）定向的CH键烯基化。不含氯化物的[Rh（OAc）（COD）] 2比市售的[RhCl（COD）] 2更好。开发了条件以控制取决于炔烃化学计量的单官能和双官能。这些新颖的双烯基化（二烷基）联芳基膦之一被用于制备钯（II）配合物，并且这些官能化的配体中的一些在空间位阻的芳基氯化物的Pd催化酰胺化反应中优于其相应的未官能化的膦。
• A New Reagent for Activating Carboxyl Groups; Preparation and Reactions of<i>N,N</i>-Bis[2-oxo-3-ox-azolidinyl]phosphorodiamidic Chloride
  作者：J. Diago-Meseguer、A. L. Palomo-Coll、J. R. Fernández-Lizarbe、A. Zugaza-Bilbao

  DOI：10.1055/s-1980-29116

  日期：——
• Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents
  作者：Maria Cristina Silva Lourenço、Felipe Rodrigues Vicente、Maria das Graças Muller de Oliveira Henriques、André Luis Peixoto Candéa、Raoni Schroeder Borges Gonçalves、Thais Cristina M. Nogueira、Marcelle de Lima Ferreira、Marcus Vinícius Nora de Souza

  DOI：10.1016/j.bmcl.2007.09.096

  日期：2007.12

  The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mu g/mL. The compounds 2, 3, 7, 8,11, 12, 15,16, and 20 exhibited activity between 25 and 100 mu g/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant tuberculosis. (c) 2007 Elsevier Ltd. All rights reserved.