nonan-4-one-(4-nitro-phenylhydrazone)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: nonan-4-one-(4-nitro-phenylhydrazone)
• 英文别名: Nonan-4-on-(4-nitro-phenylhydrazon)；Non-4-on-p-nitrophenylhydrazon
• 化学式: C₁₅H₂₃N₃O₂
• 分子量: 277.367
• InChiKey: RQFCLFAHRAXEMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.74
• 重原子数：
  20.0
• 可旋转键数：
  9.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  67.53
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  己酰氯 生成 nonan-4-one-(4-nitro-phenylhydrazone)
  参考文献：
  名称：

  Karrer et al., Helvetica Chimica Acta, 1932, vol. 15, p. 234

  摘要：

  DOI：

文献信息

• Karrer et al., Helvetica Chimica Acta, 1932, vol. 15, p. 234
  作者：Karrer et al.

  DOI：——

  日期：——
• A study of the patterns and correlates of substance use among adolescents applying for drug treatment
  作者：Catherine Spooner、Richard P. Mattick、Wesley Noffs

  DOI：10.1111/j.1467-842x.2000.tb00499.x

  日期：2000.10

  Objective: To inform planners by providing a psychosocial and drug-use profile of adolescents who have applied for a drug-treatment program.Method: The setting was a residential drug-treatment program in Sydney for adolescents from NSW and the ACT. The design was a descriptive study of consecutive program applicants over 18 months. Study participants were 14-18 years, 53% were male. Most assessments were telephone interviews. The instrument incorporated the Opiate Treatment Index, Adolescent Drug Abuse Diagnosis, Severity of Dependence Scale and Symptom Checklist 90-Revised (SCL-90-R).Results: Study participants tended to be poly-substa nce users, mostly using cannabis, heroin and/or alcohol. Heavy use in terms of frequency and amounts of use were reported, e.g. 50% of the sample used heroin daily and the mean number of standard drinks consumed on the last day of drinking was 18. High levels of problems in the areas of social functioning, criminal activity, psychological distress, physical health, HIV risk and substance dependence were reported. For example, most participants were unemployed and 88% had committed a crime in the previous month. Higher rates of some problems were identified among females, heroin users and benzodiazepine users.Conclusions: The sample reported a high level of involvement in substance use and associated problems. The profile suggested that improvements might be difficult to achieve and to maintain.Implications: A comprehensive, intensive, longer-term drug-treatment program to address the number and extent of substance-related problems for such adolescents is recommended.