1H-吡咯-2,5-二酮,1-甲基-3-(1-甲基乙基)-(9CI) | 132162-20-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1H-吡咯-2,5-二酮,1-甲基-3-(1-甲基乙基)-(9CI)
• 英文名称: 3-Isopropyl-1-methyl-pyrrole-2,5-dione
• 英文别名: 3-Isopropyl-1-methyl-1H-pyrrole-2,5-dione；1-methyl-3-propan-2-ylpyrrole-2,5-dione
• CAS: 132162-20-0
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: GGSBNYUAHSOFOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氯-丙-2-基汞 、 1H-吡咯-2,5-二酮,1-甲基-3-(1-甲基乙基)-(9CI) 在 三乙烯二胺 、 potassium iodide 作用下， 生成 3,4-Diisopropyl-1-methyl-pyrrole-2,5-dione
  参考文献：
  名称：

  Effects of iodide ion and amines on the free radical alkylation of 1,4-enediones by alkylmercury halides

  摘要：

  DOI：

  10.1016/s0040-4039(00)97040-0
• 作为产物：
  描述：

  N-甲基马来酰亚胺 、 氯-丙-2-基汞 在 三乙烯二胺 、 potassium iodide 作用下， 生成 1H-吡咯-2,5-二酮,1-甲基-3-(1-甲基乙基)-(9CI)
  参考文献：
  名称：

  Effects of iodide ion and amines on the free radical alkylation of 1,4-enediones by alkylmercury halides

  摘要：

  DOI：

  10.1016/s0040-4039(00)97040-0

文献信息

• [EN] TRIOXACARCIN-ANTIBODY CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS TRIOXACARCINE-ANTICORPS ET UTILISATIONS ASSOCIÉES
  申请人：HARVARD COLLEGE

  公开号：WO2019032961A1

  公开（公告）日：2019-02-14

  Provided herein are trioxacarcin-antibody drug conjugates of Formula (I): and pharmaceutically acceptable salts thereof, wherein R7 is -L-B, wherein L is a linking group, and B is an antibody or antibody fragment. Also provided are methods of preparing the antibody-drug conjugates, pharmaceutically acceptable compositions thereof, and methods of their use and treatment. Further provided are precursors to the trioxacarcin- antibody drug conjugates (e.g., compounds of Formula (II), novel trioxacarcins without an antibody conjugated thereto), pharmaceutical compositions thereof, and methods of their use and treatment.

  本发明提供了三氧杂卡林-抗体药物偶联物，其化学公式为(I)：以及药用可接受的盐，其中R7是-L-B，L是连接基团，B是抗体或抗体片段。还提供了制备抗体-药物偶联物的方法，药用可接受的组合物，以及其使用和治疗方法。进一步提供的是三氧杂卡林-抗体药物偶联物的前体（例如，化学公式为(II)的化合物，没有抗体偶联的新三氧杂卡林），其药用组合物，以及其使用和治疗方法。
• HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US20150274738A1

  公开（公告）日：2015-10-01

  Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which binds, covalently or non-covalently, a kinase, such as Her3 protein kinase; L 1 represents a linker; and R H represents a hydrophobic group. An example of a compound of Formula (I) is a compound of Formula (II): Also provided are pharmaceutical compositions comprising a compound of Formula (I) or (II) and methods of using such compounds for treating proliferative diseases.

  提供的是公式（I）的双功能小分子或其药学上可接受的盐，其中M代表结合激酶的小有机分子，可以是共价或非共价结合，例如Her3蛋白激酶；L1代表连接物；RH代表疏水基团。公式（I）的一个化合物示例是公式（II）的化合物： 还提供了包含公式（I）或（II）化合物的药物组合物，以及使用这些化合物治疗增殖性疾病的方法。
• Macrolides and methods of their preparation and use
  申请人：President and Fellows of Harvard College

  公开号：US10913764B2

  公开（公告）日：2021-02-09

  Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

  本文提供了通过东半部和西半部偶联，然后大环化来制备大环内酯的方法，以提供大环内酯，包括已知大环内酯和新型大环内酯。还提供了合成大环内酯（包括东半部和西半部）的中间体。还提供了使用本发明大环内酯类药物治疗传染性疾病和炎症的药物组合物和方法。还提供了用于合成西半部分的一般非对映选择性醛醇方法。
• USING SORTASES TO INSTALL CLICK CHEMISTRY HANDLES FOR PROTEIN LIGATION
  申请人：Ploegh Hidde L

  公开号：US20140249296A1

  公开（公告）日：2014-09-04

  Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.
• SORTASE-MODIFIED VHH DOMAINS AND USES THEREOF
  申请人：Whitehead Institute for Biomedical Research

  公开号：US20150086576A1

  公开（公告）日：2015-03-26

  In some aspects, polypeptides comprising single domain antibodies and methods of identifying single domain antibodies are provided. In some embodiments polypeptides comprising a single domain antibody and a sortase recognition sequence, are provided. In some aspects, products and methods of use in modulating the immune system, e.g., modulating an immune response, are provided.