2,2-dimethyl-succinyl chloride | 66734-50-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 2,2-dimethyl-succinyl chloride
• 英文别名: 2,2-dimethylsuccinyl dichloride；2,2-dimethylbutanedioyl dichloride
• CAS: 66734-50-7
• 化学式: C₆H₈Cl₂O₂
• 分子量: 183.034
• InChiKey: BGPBFIBJAZKFJR-UHFFFAOYSA-N

物化性质

• 沸点：
  80-85 °C(Press: 13 Torr)
• 密度：
  1.265±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-succinyl chloride 在 苯 作用下， 生成 2,2-dimethyl-succinic acid bis-(1-methyl-3-trimethylammonio-propylester); diiodide
  参考文献：
  名称：

  Mndshojan et al., Izvestiya Akademii Nauk Armyanskoi SSR, Khimicheskie Nauki, 1959, vol. 12, p. 359,362

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2-二甲基琥珀酸 在 五氯化磷 作用下， 生成 2,2-dimethyl-succinyl chloride
  参考文献：
  名称：

  Barnstein, Justus Liebigs Annalen der Chemie, 1887, vol. 242, p. 139

  摘要：

  DOI：

文献信息

• DIARYLMETHYLAMIDE DERIVATIVE HAVING ANTAGONISTIC ACTIVITY ON MELANIN-CONCENTRATING HORMONE RECEPTOR
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：EP2272841A1

  公开（公告）日：2011-01-12

  [Problem] To provide a melanin-concentrating hormone receptor antagonist useful as a pharmaceutical agent for central diseases, circulatory diseases, and metabolic diseases. [Means for Resolution] Provided is a diarylmethylamide derivative represented by formula (I): Wherein R1a, R1b, R2a, R2b, R3a, and R3b independently represent a hydrogen atom or the like, R4 represents a hydrogen atom, C1-6 alkyl, or the like, R5 represents a hydrogen atom or the like, Z represents C1-6 alkyl or the like, or R4 and Z together form a 4- to 6-membered nitrogen-containing hetero ring, Y1 represents H or the like, Y2 represents H, or Y1 and Y2 together form - O-CH2-, W represents C, SO, or the like, Ar1 represents 6-membered aryl or the like, Ar2 represents 6-membered aryl or the like, and ring A represents a benzene ring, a pyridine ring, or the like.

  [问题] 提供一种对黑色素浓缩激素受体拮抗剂，用作中枢疾病、循环疾病和代谢疾病的药用制剂。 [解决方法] 提供一种由式(I)表示的二芳基甲酰胺衍生物： 其中R1a、R1b、R2a、R2b、R3a和R3b独立地表示氢原子或类似物，R4表示氢原子、C1-6烷基或类似物，R5表示氢原子或类似物，Z表示C1-6烷基或类似物，或者R4和Z一起形成一个含氮杂环的4-至6-成员环，Y1表示H或类似物，Y2表示H，或者Y1和Y2一起形成-O-CH2-，W表示C、SO或类似物，Ar1表示6-成员芳基或类似物，Ar2表示6-成员芳基或类似物，环A表示苯环、吡啶环或类似物。
• Unsymmetrical diperoxides and processes of use in polymerizing
  申请人：Pennwalt Corporation

  公开号：US04219676A1

  公开（公告）日：1980-08-26

  Unsymmetrical diperoxides of the general structure: ##STR1## for example, 4-(t-butylperoxycarbonyl)-3-hexyl-6-[7-(tbutylperoxycarbonyl)heptyl] cyclohexene, are useful for polymerizing ethylenically unsaturated monomers (such as styrene). The polymerizations can be carried out at higher temperatures and in shorter times than with conventional initiator systems, without detrimental decrease in polymer molecular weight or significant change in molecular weight distribution. The unsymmetrical diperoxides are also useful as catalysts for curing unsaturated polyester resins.

  通式为：##STR1## 的非对称双过氧化物，例如4-(叔丁基过氧羰基)-3-己基-6-[7-(叔丁基过氧羰基)庚基]环己烯，可用于聚合乙烯基不饱和单体（如苯乙烯）。相比传统的引发剂系统，聚合反应可以在更高的温度和更短的时间内进行，而不会对聚合物分子量产生不利的影响或者显著改变分子量分布。非对称双过氧化物也可用作催化剂，用于固化不饱和聚酯树脂。
• DIARYLMETHYLAMIDE DERIVATIVE HAVING MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISM
  申请人：Kamijo Kaori

  公开号：US20110015198A1

  公开（公告）日：2011-01-20

  [Problem] To provide a melanin-concentrating hormone receptor antagonist useful as a pharmaceutical agent for central diseases, circulatory diseases, and metabolic diseases. [Means for Resolution] Provided is a diarylmethylamide derivative represented by formula (I): Wherein R 1a , R 1b , R 2a , R 2b , R 3a , and R 3b independently represent a hydrogen atom or the like, R 4 represents a hydrogen atom, C 1-6 alkyl, or the like, R 5 represents a hydrogen atom or the like, Z represents C 1-6 alkyl or the like, or R 4 and Z together form a 4- to 6-membered nitrogen-containing hetero ring, Y 1 represents H or the like, Y 2 represents H, or Y 1 and Y 2 together form —O—CH 2 —, W represents C, SO, or the like, Ar 1 represents 6-membered aryl or the like, Ar 2 represents 6-membered aryl or the like, and ring A represents a benzene ring, a pyridine ring, or the like.

  [问题] 提供一种黑色素浓缩激素受体拮抗剂，用作中枢疾病、循环系统疾病和代谢疾病的药物。 [解决方法] 提供了一种日萘基甲酰胺衍生物，其表示为式（I）：其中，R1a、R1b、R2a、R2b、R3a和R3b独立地表示氢原子或类似物，R4表示氢原子、C1-6烷基或类似物，R5表示氢原子或类似物，Z表示C1-6烷基或类似物，或者R4和Z共同形成一个含有氮的4-6元杂环，Y1表示H或类似物，Y2表示H，或者Y1和Y2共同形成-O-CH2-，W表示C、SO或类似物，Ar1表示6元芳基或类似物，Ar2表示6元芳基或类似物，环A表示苯环、吡啶环或类似物。
• Methods and apparatus for accelerated orthokeratology
  申请人：——

  公开号：US20010016731A1

  公开（公告）日：2001-08-23

  An accelerated method of orthokeratology includes the steps of softening of the cornea with a softening agent, applying a mold to reshape the cornea to a desired anterior curvature, and rapidly restabilizing or “fixing” the corneal tissues so that the cornea retains its new configuration. A chemical softening agent, such as glutaric anhydride is applied to the cornea to soften the cornea, after which a specially designed mold of predetermined curvature and configuration is applied to the cornea. Slight downward pressure is applied to the mold for a predetermined period of time to re-shape the cornea. The mold is maintained in position while a stabilizing agent, such as a UV light source, is positioned above the mold. The stabilizing agent, i.e. UV light, is applied to the cornea for a predetermined time, wherein the stabilizing agent immediately restabilizes the corneal tissue so that the cornea immediately retains its shape upon removal of the mold. The stabilization process can also be used for patients having already undergone traditional orthokeratology to eliminate the need to continue wearing a retainer to maintain the shape of the cornea.

  角膜矫形术的加速方法包括以下步骤：用软化剂软化角膜，使用模具将角膜重塑成所需的前弧度，并迅速重新稳定或 "固定 "角膜组织，使角膜保持新的形态。在角膜上涂抹化学软化剂（如戊二酸酐）以软化角膜，然后在角膜上涂抹专门设计的具有预定弧度和结构的模具。在预定时间内对模具施加轻微的向下压力，以重新塑形角膜。将稳定剂（如紫外线光源）置于模具上方时，模具将保持在原位。将稳定剂（即紫外线）照射到角膜上，持续预定的时间，其中稳定剂会立即重新稳定角膜组织，使角膜在移除模具后立即保持其形状。稳定过程也可用于已接受传统角膜矫形术的患者，使其无需继续佩戴保持器来保持角膜的形状。
• Levy; Englaender, Justus Liebigs Annalen der Chemie, 1887, vol. 242, p. 201
  作者：Levy、Englaender

  DOI：——

  日期：——