o-nitrobenzylsulfide | 99366-73-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-nitrobenzylsulfide
• 英文别名: 1-nitro-3-{[(3-nitrophenyl)methane]sulfanylmethyl}benzene；bis-(2-nitro-benzyl)-sulfide；Bis-(2-nitro-benzyl)-sulfid；2.2'-Dinitro-dibenzylsulfid；Orthonitrobenzylsulfid；1-nitro-2-[(2-nitrophenyl)methylsulfanylmethyl]benzene
• CAS: 99366-73-1
• 化学式: C₁₄H₁₂N₂O₄S
• 分子量: 304.326
• InChiKey: HTSLOVWOMBDCQR-UHFFFAOYSA-N

物化性质

• 熔点：
  120-122 °C
• 沸点：
  451.3±30.0 °C(Predicted)
• 密度：
  1.379±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  117
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  o-nitrobenzylsulfide 在 4-羟乙基哌嗪乙磺酸 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 0.17h， 生成 2-nitrosobenzaldehyde
  参考文献：
  名称：

  Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages

  摘要：

  我们报告了一种可直接光控的硫化氢（H2S）供体的设计、合成和应用，这种供体可根据光照强度和持续时间按比例释放 H2S。在牛血清中也证明了这种供体的光控 H2S 释放。这种 H2S 供体适用于各种生物系统。

  DOI：

  10.1039/c3cc47421f
• 作为产物：
  描述：

  o-nitrobenzyldimethylsulfonium bromide 在 水 作用下， 反应 24.0h， 以48%的产率得到o-nitrobenzylsulfide
  参考文献：
  名称：

  Stanc, Yannick Le; Corre, Maurice Le, Canadian Journal of Chemistry, 1985, vol. 63, p. 2958 - 2960

  摘要：

  DOI：

文献信息

• Trisulfides over disulfides: highly selective synthetic strategies, anti-proliferative activities and sustained H₂S release profiles
  作者：Debojit Bhattacherjee、Abu Sufian、Sulendar K. Mahato、Samiyara Begum、Kaustav Banerjee、Sharmistha De、Hemant Kumar Srivastava、Krishna P. Bhabak

  DOI：10.1039/c9cc05562b

  日期：——

  Temperature- and solvent-induced selective synthesis of trisulfides and disulfides is demonstrated. A remarkable selectivity was achieved using Na2S as a sulfur-transfer agent under mild, greener, catalyst-free and additive-free conditions. This study reveals trisulfides as a better model than disulfides in general for a sustained release of H2S and potent anti-cancer activities.

  证明了温度和溶剂诱导的三硫化物和二硫化物的选择性合成。使用Na 2 S作为硫转移剂，可在温和，绿色，无催化剂和无添加剂的条件下实现显着的选择性。这项研究表明，对于持续释放H 2 S和有效的抗癌活性，三硫化物通常比二硫化物更好。
• 8-ARM POLYETHYLENE GLYCOL DERIVATIVE, MANUFACTURING METHOD AND MODIFIED BIO-RELATED SUBSTANCE THEREBY
  申请人：Xiamen Sinopeg Biotech Co., Ltd.

  公开号：EP3315531A1

  公开（公告）日：2018-05-02

  Disclosed are an 8-arm polyethylene glycol (PEG) derivative (formula 1), manufacturing method and modified bio-related substance thereby, wherein a tetravalent group U and four trivalent groups Ec form a highly symmetric octavalent central structure CORE0 together, Lc connects the octavalent center to eight PEG arms having polydiversity or monodiversity and having n1-n8 as the degrees of polymerization thereof. The terminal of one PEG chain is connected to at least one functional group F (k ≥ 1), and said PEG chain and F can be directly connected (g = 0) or connected with a divalent linking group L0 connected with a terminal branched group G (g = 1) therebetween. The latter provides more reacting sites to combine more pharmaceutical molecules, thereby increasing the drug loading capacity. The near-center symmetric structure of the derivative allows more precise control over the molecular weight during large-scale production, thereby facilitating acquisition of a product having a narrower molecular weight distribution. A bio-related substance modified thereby has a more uniform and controllable performance.

  本发明公开了一种 8 臂聚乙二醇（PEG）衍生物（式 1）、其制造方法和改性生物相关物质，其中一个四价基团 U 和四个三价基团 Ec 共同形成一个高度对称的八价中心结构 CORE0，Lc 将八价中心连接到八个 PEG 臂上，这些 PEG 臂具有多元性或单元性，其聚合度为 n1-n8。一条 PEG 链的末端与至少一个官能团 F（k ≥ 1）相连，所述 PEG 链和 F 可以直接相连（g = 0），也可以通过二价连接基 L0 与中间的末端支化基 G（g = 1）相连。后者提供了更多的反应位点，可以结合更多的药物分子，从而提高药物负载能力。衍生物的近中心对称结构可以在大规模生产过程中更精确地控制分子量，从而有利于获得分子量分布更窄的产品。由此改性的生物相关物质具有更均匀、更可控的性能。
• PREPARATION, RAW MATERIALS, PRODUCT, AND APPLICATION OF PHOTOCROSSLINKED HYDROGEL MATERIAL
  申请人：Zhongshan Guanghe Medical Technology Co., Ltd.

  公开号：EP3666761A1

  公开（公告）日：2020-06-17

  This invention provides preparations, compositions, products, and applications of photo-crosslinked hydrogels. Component A - a photosensitive polymer derivative, component B - the photoinitiator, and auxiliary component C - other biocompatible polymer derivative each are respectively dissolved in a biocompatible medium to obtain solution A, solution B, and solution C. The solution A, the solution B, and the optional solution C are mixed homogenously to obtain a hydrogel precursor solution. The hydrogel precursor solution is subject to irradiation of the UV light for photocoupled crosslinking to form a photo-crosslinked hydrogel. The photo-crosslinked hydrogel exhibit rapid speed of photo-curing, strong tissue adhesion, excellent mechanical properties, good biocompatibility, and excellent clinical operability. In addition, this invention also provides a kit for making the photo-crosslinked hydrogel, and applications thereof in tissue engineering, regenerative medicine, 3D printing, and as a carrier of cell, protein, or drug.

  本发明提供了光交联水凝胶的制备方法、组合物、产品和应用。将组分 A--光敏聚合物衍生物、组分 B--光引发剂和辅助组分 C--其他生物相容性聚合物衍生物分别溶解在生物相容性介质中，得到溶液 A、溶液 B 和溶液 C。将水凝胶前体溶液置于紫外线照射下进行光耦合交联，形成光交联水凝胶。光交联水凝胶具有光固化速度快、组织粘附力强、机械性能优异、生物相容性好、临床可操作性强等特点。此外，本发明还提供了一种用于制作光交联水凝胶的试剂盒，及其在组织工程、再生医学、3D 打印以及作为细胞、蛋白质或药物载体中的应用。
• Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US10434182B2

  公开（公告）日：2019-10-08

  Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups Ec form a highly symmetrical octavalent group CORE0; Lc connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n1 to n8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.

  本发明公开了一种八臂聚乙二醇（PEG）衍生物（式 I）、其生产方法及其改性生物相关物质。其中，一个四价基团 U 与四个三价基团 Ec 形成一个高度对称的八价基团 CORE0；Lc 将八价基团连接到八条具有多分散性或单分散性且聚合度为 n1 至 n8 的 PEG 链上；一条 PEG 链的末端与至少一个官能团 F 连接（k≥1）；所述 PEG 链和 F 之间可以直接连接（g=0），也可以通过连接基团 L0 与末端支化基团 G 间接连接（g=1）；后者提供了更多的反应位点，可以结合更多的药物分子，增加药物负载量。八臂聚乙二醇衍生物具有中心对称或近似中心对称结构，因此在大规模生产中可以更精确地控制分子量，产品的分子量分布也更窄。因此，改性生物相关物质的性能更均匀、更可控。
• Photo-crosslinked hydrogel material and preparation, composition, and application thereof photo-crosslinked hydrogel
  申请人：Zhongshan Guanghe Medical Technology Co., Ltd.

  公开号：US11117879B2

  公开（公告）日：2021-09-14

  This invention provides preparations, compositions, products, and applications of photo-crosslinked hydrogels. Component A—a photosensitive polymer derivative, component B—the photoinitiator, and auxiliary component C—other biocompatible polymer derivative each are respectively dissolved in a biocompatible medium to obtain solution A, solution B, and solution C. The solution A, the solution B, and the optional solution C are mixed homogenously to obtain a hydrogel precursor solution. The hydrogel precursor solution is subject to irradiation of the UV light for photocoupled crosslinking to form a photo-crosslinked hydrogel. The photo-crosslinked hydrogel exhibit rapid speed of photo-curing, strong tissue adhesion, excellent mechanical properties, good biocompatibility, and excellent clinical operability. In addition, this invention also provides a kit for making the photo-crosslinked hydrogel, and applications thereof in tissue engineering, regenerative medicine, 3D printing, and as a carrier of cell, protein, or drug.

  本发明提供光交联水凝胶的制备、组合物、产品和应用。组分A—光敏聚合物衍生物、组分B—光引发剂以及辅助组分C—其他生物相容性聚合物衍生物分别溶解于生物相容性介质中，以分别获得溶液A、溶液B和溶液C。将所述溶液A、溶液B以及可选的溶液C混合均匀，得到水凝胶前体溶液;所述水凝胶前体溶液在紫外光辐照下进行光偶联交联，形成光交联水凝胶。所述光交联水凝胶展现出光固化速度快、组织粘附性强、力学性能优异、生物相容性良好以及临床操作性优异的特点。此外，本发明还提供所述光交联水凝胶的制备试剂盒及该水凝胶在组织工程、再生医学、三维打印以及作为细胞、蛋白或药物的载体方面的应用。