1-羟基-1,2,3,4-四氢蒽 | 84194-96-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 1-羟基-1,2,3,4-四氢蒽
• 英文名称: 1-hydroxy-1,2,3,4-tetrahydroanthracene
• 英文别名: 1-Hydroxy-1,2,3,4-tetrahydroanthracen；1,2,3,4-tetrahydro-1-anthracenol；1,2,3,4-Tetrahydro-[1]anthrol；1-Oxy-1.2.3.4-tetrahydro-anthracen；ac. Tetrahydro-α-anthrol；1,2,3,4-Tetrahydroanthracen-1-ol
• CAS: 84194-96-7
• 化学式: C₁₄H₁₄O
• 分子量: 198.265
• InChiKey: PSGZNKMIODRSJR-UHFFFAOYSA-N

物化性质

• 沸点：
  385.3±11.0 °C(Predicted)
• 密度：
  1.184±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-羟基-1,2,3,4-四氢蒽 生成 3,4-dihydro-1(2H)-anthracenone
  参考文献：
  名称：

  v. Braun; Bayer, Justus Liebigs Annalen der Chemie, 1929, vol. 472, p. 104

  摘要：

  DOI：
• 作为产物：
  描述：

  1-蒽酚 在 乙醇 、 sodium 、 镍 作用下， 生成 1-羟基-1,2,3,4-四氢蒽
  参考文献：
  名称：

  v. Braun; Bayer, Justus Liebigs Annalen der Chemie, 1929, vol. 472, p. 104

  摘要：

  DOI：

文献信息

• Synthesis and Reactivity of Cinnoline-Fused Cyclic Enediyne
  作者：Olga V. Vinogradova、Irina A. Balova、Vladimir V. Popik

  DOI：10.1021/jo201148h

  日期：2011.8.19

  efficient synthesis of cinnoline-fused cyclic enediyne is reported. Richter cyclization of o-(1,3-butadiynyl)phenyltriazene produced 3-alkynyl-4-bromocinnoline. The Sonogashira coupling of the latter with 5-hexyn-1-ol was employed for the introduction of a second acetylenic moiety. The crucial cyclization step was achieved under Nozaki–Hiyama–Kishi conditions. Cinnoline-fused 10-membered ring enediyne is

  据报道，一种短而有效的合成肉桂酸稠合的环状二烯炔。邻-（1,3-丁二炔基）苯基三氮烯的更丰富的环化反应生成了3-炔基-4-溴辛啉。后者与5-己炔-1-醇的Sonogashira偶联被用于引入第二炔属部分。关键的环化步骤是在Nozaki–Hiyama–Kishi条件下完成的。辛诺林稠合的10元环烯二炔比相应的碳环类似物更具反应性，并且在温和加热下可产生良好的Bergman环化产物收率。该烯二炔在40°C孵育后诱导单链dDNA切割。
• [EN] RETINOID-LIKE COMPOUNDS<br/>[FR] COMPOSES DE TYPE RETINOIDE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：WO1998049136A1

  公开（公告）日：1998-11-05

  (EN) Certain novel substituted (5,6)-dihydroanthracenyl compounds of general formula (I), wherein A, n, p, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification exhibit retinoid-like properties and are particularly useful in the prevention of post-surgical adhesions.(FR) La présente invention concerne certains composés (5,6)-dihydroanthrencényle substitués représentés par la formule générale (I) dans laquelle R, n, p, R1, R2, R3, R4, R5, R6, R7, et R8 sont tels que définis dans les revendications. Ces composés, qui font preuve de propriétés de type de celles des rétinoïdes, conviennent particulièrement à la prévention de la formation de brides postopératoires.

  某些新型取代的（5,6）-二氢蒽基化合物的一般式（I），其中A，n，p，R1，R2，R3，R4，R5，R6，R7和R8如规范中定义的展示类似视黄醇的特性，并且在预防术后粘连方面特别有用。
• Therapeutic applications of estrogenic carboxylic acids
  申请人：Southern Illinois University

  公开号：US20040116398A1

  公开（公告）日：2004-06-17

  Provided are methods employing estrogenic compounds for: repressing weight gain or reducing weight in male patients; treating or preventing prostate cancer and peri- or post-menopausal symptoms; treating estrogen-responsive conditions that no longer respond to treatment with conventional steroidal estrogens; treating or preventing estrogen-responsive uterine cancer, breast cancer, and ovarian follicle atresia; inducing ovulation to increase fertility; oral contraception; treating or preventing diseases or conditions caused or prolonged by free radicals; treating or preventing cardiovascular disease, hyperlipidemia or hypercholesterolemia, and hyperglycemia; improving body fat distribution; and treating or preventing Alzheimer's disease, osteoporosis, and pattern baldness. Also provided are methods for treating or preventing prostatic diseases including benign prostate hyperplasia and other related conditions, androgen-responsive pathological conditions in males, and methods for male birth control and chemical castration, employing estrogenic carboxylic acids.

  本发明提供了采用雌激素化合物的方法，用于抑制男性患者体重增加或减轻体重；治疗或预防前列腺癌和围绝经期或绝经后症状；治疗对传统甾体雌激素治疗不再有反应的雌激素反应性疾病；治疗或预防雌激素反应性子宫癌、乳腺癌和卵巢滤泡闭锁；诱导排卵以提高生育能力；口服避孕药；治疗或预防由自由基引起或延长的疾病或病症；治疗或预防心血管疾病、高脂血症或高胆固醇血症和高血糖症；改善体内脂肪分布；以及治疗或预防老年痴呆症、骨质疏松症和斑秃。此外，还提供了利用雌激素羧酸治疗或预防前列腺疾病（包括良性前列腺增生和其他相关疾病）、男性雄激素反应性病理状况以及男性节育和化学阉割的方法。
• Arene 1,4-Diradical Formation from o-Dialkynylarenes
  作者：M. F. Semmelhack、Thomas Neu、Francisco Foubelo

  DOI：10.1021/jo00096a057

  日期：1994.8

  A series of 10-membered cyclic 1,5-diynes has been prepared with arene rings fused at positions C-3/C-4. The arenes include simple benzene rings, a naphthoquinone and naphthohydroquinone, and an anthraquinone and anthracene unit. Consistent with a simple picture relating the extent of double bond character in the ene part of the ene-diyne with the rate of arene-l,l-diyl formation, the hydroquinone derivatives were much less reactive compared to the corresponding quinones. Substituents such as propargylic hydroxyl or keto group have a small but significant activating effect. The parent 3,4-benzo-1,8-decadiyne shows a half-life for rearrangement of 24 h at 84 degrees C while the corresponding alkene, cyclodec-3-ene-1,5-diyne is reported to have a half-life of 18 h at 37 degrees C.
• Product stereospecificity in the microbial reductions of hydroaromatic ketones
  作者：Kuninobu Kabuto、Mitsuru Imuta、Ellis S. Kempner、Herman Ziffer

  DOI：10.1021/jo00406a011

  日期：1978.6