3-氯-2,5-二乙基吡嗪 | 67714-53-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 3-氯-2,5-二乙基吡嗪
• 英文名称: 3-chloro-2,5-diethylpyrazine
• 英文别名: 3-chloro-2,5-diethyl-pyrazine；2-chloro-3,6-diethylpyrazine；3,6-diethyl-2-chloropyrazine；2-chloro-3,6-diethyl Pyrazine；2-Chlor-3,6-diaethylpyrazin
• CAS: 67714-53-8
• 化学式: C₈H₁₁ClN₂
• mdl: MFCD09265273
• 分子量: 170.642
• InChiKey: OHKRYVAKYCCYNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  3-氯-2,5-二乙基吡嗪 在 苯甲酰胺 、 potassium carbonate 作用下， 反应 1.0h， 以80%的产率得到3,6-二乙基-吡嗪胺
  参考文献：
  名称：

  Watanabe, Tokuhiro; Kikuchi, Etsuko; Tamura, Wataru, Heterocycles, 1980, vol. 14, # 3, p. 287 - 290

  摘要：

  DOI：
• 作为产物：
  描述：

  3,6-二乙基-2,5-哌嗪二酮 在 四甲基氯化铵 、 三氯氧磷 作用下， 以 1,4-二氧六环 为溶剂， 以88%的产率得到3-氯-2,5-二乙基吡嗪
  参考文献：
  名称：

  Synthesis of 2-chloro-3,6-dialkyl pyrazines

  摘要：

  公开了一种生产3,6-二烷基-2,5-哌嗪二酮的方法。

  公开号：

  US20050107610A1

文献信息

• Substituted aryl 1,4-pyrazine derivatives
  申请人：Verhoest R. Patrick

  公开号：US20060211710A1

  公开（公告）日：2006-09-21

  The invention is directed to compounds of Formula I, described herein, as well as pharmaceutically acceptable salts thereof, which act as CRF 1 antagonists and are useful in the treatment of disorders and diseases associated with CRF 1 receptors, including CNS-related disorders and diseases.

  该发明涉及本文描述的Formula I化合物，以及其药学上可接受的盐，这些化合物作为CRF 1 拮抗剂，在治疗与CRF 1 受体相关的疾病和疾病中起作用，包括与中枢神经系统相关的疾病和疾病。
• [EN] SUBSTITUTED PYRAZINE DERIVATIVES<br/>[FR] DERIVES PYRAZINIQUES SUBSTITUES
  申请人：UPJOHN CO

  公开号：WO2003091225A1

  公开（公告）日：2003-11-06

  The present invention provides substituted pyrazine derivatives of Formula (I), that are CRF1 receptor antagonists, including human CRF1 receptors. This invention also relates to use of compounds of the invention for treating a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders, particularly anxiety-related disorders and mood disorders.

  本发明提供了式（I）的取代吡嗪衍生物，其为CRF1受体拮抗剂，包括人类CRF1受体。本发明还涉及利用本发明的化合物治疗疾病或症状，其治疗可以通过拮抗CRF受体来实现或促进，例如中枢神经系统疾病，特别是与焦虑有关的疾病和情绪障碍。
• [EN] 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS<br/>[FR] 2-ARYLPYRAZINES SUBSTITUEES EN 5 COMME MODULATEURS SUR LES RECEPTEURS CRF
  申请人：NEUROGEN CORP

  公开号：WO2004018437A1

  公开（公告）日：2004-03-04

  Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyrazine compounds provided herein are useful in the treatment of a number of CNS and peripheral disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

  提供了一种新型的5-取代-2-芳基吡嗪化合物。这些化合物可以作为CRF受体的选择性调节剂。本文提供的5-取代-2-芳基吡嗪化合物在治疗多种中枢神经系统和外周疾病方面具有用途，特别是压力、焦虑、抑郁、心血管疾病和进食障碍。还提供了治疗这些疾病的方法以及包装的药物组合物。提供的化合物还可用作CRF受体的定位探针和CRF受体结合测定中的标准。给出了在受体定位研究中使用这些化合物的方法。
• 2,5-diarylpyrazines, 2,5-diarylpyridines and 2,5-diarylpyrimidines
  申请人：Neurogen Corporation

  公开号：US20030119844A1

  公开（公告）日：2003-06-26

  Diarylpyrazine, diarylpyridine, and diarylpyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of Formula I are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

  提供作为CRF 1受体选择性调节剂的Diarylpyrazine、diarylpyridine和diarylpyrimidine化合物。这些化合物对治疗多种中枢神经系统和外周疾病特别有效，包括压力、焦虑、抑郁、心血管疾病和进食障碍。还提供了治疗这些疾病的方法以及包装的药物组合物。Formula I的化合物也可用作CRF受体的定位探针和CRF受体结合测定中的标准。给出了使用这些化合物进行受体定位研究的方法。
• Substituted arylpyrazines
  申请人：——

  公开号：US20030018035A1

  公开（公告）日：2003-01-23

  Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affinity and high selectivity to CRF 1 receptors, including human CRF 1 receptors. The invention thus includes methods for treatment of disorders and diseases associated with CRF 1 receptors, including CNS-related disorders and diseases, particularly affective disorders and diseases, and acute and chronic neurological disorders and diseases.

  提供了芳基吡嗪化合物，包括可以与CRF1受体结合并具有高亲和力和高选择性的芳基吡嗪，包括人类CRF1受体。因此，该发明涉及用于治疗与CRF1受体相关的疾病和疾病的方法，包括与中枢神经系统相关的疾病和疾病，特别是情感障碍和疾病以及急性和慢性神经系统疾病。