p-phenylene-3,3'-bis(allyl bromide) | 153759-64-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-phenylene-3,3'-bis(allyl bromide)
• 英文别名: 1,4-bis((E)-3-bromoprop-1-en-1-yl)benzene；1,4-bis[(E)-3-bromoprop-1-enyl]benzene
• CAS: 153759-64-9
• 化学式: C₁₂H₁₂Br₂
• 分子量: 316.035
• InChiKey: XAARFOCHHFSFOS-ZPUQHVIOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  四氢噻吩 、 p-phenylene-3,3'-bis(allyl bromide) 以 甲醇 、 氯仿 为溶剂， 以76%的产率得到p-phenylene-3,3'-bis(1-allyltetrahydrothiophenium) dibromide
  参考文献：
  名称：

  Preparation of p-phenylene-3,3′-bis(1-allyltetrahydrothiophenium) dibromide and its reactions in basic solution

  摘要：

  p-Phenylene-3,3'-bis(1-allyltetrahydrothiophenium) dibromide 1, prepared from p-phenylene-3,3'-diacrylaldehyde 3, when treated with aqueous sodium hydroxide gave a sulfonium salt polymer. Pyrolysis of this in an attempt to form the highly conjugated polymer, poly(p-phenylenehexa-1,3,5-trienylene) gave, however. only carbonyl-containing compounds. Although no polymerization occurred in basic methanol. a reaction intermediate was shown by UV-VIS and H-1 NMR spectroscopy to have been formed.

  DOI：

  10.1039/p19940000317
• 作为产物：
  描述：

  p-phenylene-3,3'-bis(allyl alcohol) 在 溴 、 三苯基膦 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以69%的产率得到p-phenylene-3,3'-bis(allyl bromide)
  参考文献：
  名称：

  Preparation of p-phenylene-3,3′-bis(1-allyltetrahydrothiophenium) dibromide and its reactions in basic solution

  摘要：

  p-Phenylene-3,3'-bis(1-allyltetrahydrothiophenium) dibromide 1, prepared from p-phenylene-3,3'-diacrylaldehyde 3, when treated with aqueous sodium hydroxide gave a sulfonium salt polymer. Pyrolysis of this in an attempt to form the highly conjugated polymer, poly(p-phenylenehexa-1,3,5-trienylene) gave, however. only carbonyl-containing compounds. Although no polymerization occurred in basic methanol. a reaction intermediate was shown by UV-VIS and H-1 NMR spectroscopy to have been formed.

  DOI：

  10.1039/p19940000317

文献信息

• OXYNTOMODULIN ANALOGS AND METHODS OF MAKING AND USING SAME
  申请人：The Research Foundation for The State University of New York

  公开号：US20170196940A1

  公开（公告）日：2017-07-13

  Provided are oxyntomodulin analogs. The peptide analogs have at least two cysteines. The two cysteines are separated by six amino acids such that they can be crosslinked using suitable crosslinking moieties. The crosslinked peptides have long half-lives and/or efficacy. For example, peptide analog compositions are used for inducing weight loss and/or reducing blood glucose levels.

  提供的是氧子脱氨酮素类似物。这些肽类似物至少含有两个半胱氨酸。这两个半胱氨酸之间相隔六个氨基酸，使它们可以通过适当的交联基团进行交联。交联的肽具有较长的半衰期和/或疗效。例如，肽类似物组合用于诱导减重和/或降低血糖水平。
• Solvent/metal-free benzimidazolium-based carboxyl-functionalized porphyrin photocatalysts for the room-temperature alkylation of amines under the irradiation of visible light
  作者：Subodh Uttamrao Raut、Kamlesh Rudreshwar Balinge、Shubham Avinash Deshmukh、Shital Haribhau Barange、Bhairav Chandroday Mataghare、Pundlik Rambhau Bhagat

  DOI：10.1039/d2cy00846g

  日期：——

  morpholine, and various alcohols, with water being the only by-product. The metal-free protocol was further supported by the ICP-OES data, indicating the negligible quantity of Pd/Ru in the photocatalyst and the product. The photocatalytic competence was studied under ambient conditions using 5 W LED light with high stability and substantial reusability for six runs without significant loss in the yield of alkylated

  改进用于绿色化学生产的新型可持续催化方法是化学科学中的一个新兴领域。在此，首次开发了一种可持续的催化工艺，用于直接N- 在 LED 灯存在的情况下，在自制的光催化反应器中，使用高效的无金属苯并咪唑基羧基官能化卟啉 (MFBBCFPc) 多相光催化剂将伯胺和仲胺与醇进行烷基化。在这种情况下，目前的协议证明了无金属条件可耐受广泛的底物范围，包括伯胺、苯二胺和二级胺，如吡咯、吗啉和各种醇，水是唯一的副产品。ICP-OES 数据进一步支持了无金属方案，表明光催化剂和产品中 Pd/Ru 的量可忽略不计。在环境条件下使用 5 W LED 灯研究了光催化能力，该灯具有高稳定性和基本可重复使用性，可重复使用六次，而不会显着损失烷基化产物的产率。烷基化胺的形成进行通过(i) 在 MFBBCFPc 光催化剂表面上醇的氧化形成醛和 (ii) 胺与光催化剂表面上的醛缩合，然后通过表面上的氢原子氢化所得亚胺MFBBCFPc。
• Sonoda Yoriko, Suzuki Yasuzo, J. Chem. Soc. Perkin Trans. 1, (1994) N 3, S 317-321
  作者：Sonoda Yoriko, Suzuki Yasuzo

  DOI：——

  日期：——
• US9931379B2
  申请人：——

  公开号：US9931379B2

  公开（公告）日：2018-04-03
• [EN] OXYNTOMODULIN ANALOGS AND METHODS OF MAKING AND USING SAME<br/>[FR] ANALOGUES D'OXYNTOMODULINE ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2017075583A2

  公开（公告）日：2017-05-04