4-[2-(2-Methylpiperidin-1-yl)quinazolin-4-yl]morpholine | 1195785-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-[2-(2-Methylpiperidin-1-yl)quinazolin-4-yl]morpholine
• CAS: 1195785-34-2
• 化学式: C₁₈H₂₄N₄O
• 分子量: 312.415
• InChiKey: VEUYUACXCKGLLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  41.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-甲基哌啶 、 2-氯-4-(4-吗啉)喹唑啉 以 N,N-二甲基乙酰胺 为溶剂， 生成 4-[2-(2-Methylpiperidin-1-yl)quinazolin-4-yl]morpholine
  参考文献：
  名称：

  The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

  摘要：

  We describe a novel series of potent inhibitors of the kinase activity of mTOR. The compounds display good selectivity relative to other PI3K-related kinase family members and, in cellular assays, inhibit both mTORC1 and mTORC2 complexes and exhibit good antiproliferative activity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.038

文献信息

• The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase
  作者：Karine Malagu、Heather Duggan、Keith Menear、Marc Hummersone、Sylvie Gomez、Christine Bailey、Peter Edwards、Jan Drzewiecki、Frédéric Leroux、Mar Jimenez Quesada、Gesine Hermann、Stephanie Maine、Carrie-Anne Molyneaux、Armelle Le Gall、James Pullen、Ian Hickson、Lisa Smith、Sharon Maguire、Niall Martin、Graeme Smith、Martin Pass

  DOI：10.1016/j.bmcl.2009.08.038

  日期：2009.10

  We describe a novel series of potent inhibitors of the kinase activity of mTOR. The compounds display good selectivity relative to other PI3K-related kinase family members and, in cellular assays, inhibit both mTORC1 and mTORC2 complexes and exhibit good antiproliferative activity. (C) 2009 Elsevier Ltd. All rights reserved.