3-(3,4-dimethoxyphenoxy) propanoic acid | 63434-50-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3,4-dimethoxyphenoxy) propanoic acid
• 英文别名: 3-(3,4-dimethoxy-phenoxy)-propionic acid；3-(3,4-Dimethoxy-phenoxy)-propionsaeure；3,4-dimethoxy phenoxy propionic acid；β-3,4-Dimethoxyphenoxypropionsaeure；3-(3,4-Dimethoxyphenoxy)propanoic acid
• CAS: 63434-50-4
• 化学式: C₁₁H₁₄O₅
• 分子量: 226.229
• InChiKey: AJDCBYMKYSZSLT-UHFFFAOYSA-N

物化性质

• 熔点：
  136-137 °C
• 沸点：
  350.3±27.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  3-(3,4-dimethoxyphenoxy) propanoic acid 在 PPA 作用下， 生成 6,7-二甲氧基-3,4-二氢色烯-2-酮
  参考文献：
  名称：

  Anti-juvenile hormones

  摘要：

  揭示了一种潜在的昆虫控制化合物，即香豆素，以及它们的制备和使用方法。已发现这些化合物通过抑制幼虫激素的作用而对昆虫的控制有效。有用化合物的示例包括6,7-二甲氧基-2,2-二甲基-3-香豆素和7-甲氧基-2,2-二甲基-3-香豆素，可以从常见的床头植物蓝花艾格菊中提取。这些化合物作用于诱导不成熟昆虫的早熟，导致在蜕皮过程中或在蜕皮过程之前或之后的短时间内死亡。已获得的额外效果包括成熟昆虫的不孕化、昆虫卵的胚胎发育中断、昆虫的滞育诱导以及昆虫性信息素分泌的预防。

  公开号：

  US04656189A1
• 作为产物：
  描述：

  3-(3,4-二甲氧基苯氧基)丙腈 在 盐酸 作用下， 以54%的产率得到3-(3,4-dimethoxyphenoxy) propanoic acid
  参考文献：
  名称：

  类胡萝卜素环系统的新合成方法

  摘要：

  代表天然杀虫剂鱼藤酮的基本环系统的（±）-色铬烷酮（2）和（3）已通过通用方法合成。关键步骤是4-苯基-磺酰基）苯并二氢吡喃（4-苯甲酰基化）（7； Z = SO 2 Ph）。

  DOI：

  10.1016/s0040-4020(01)89116-x

文献信息

• Ingestibles containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers
  申请人：BIORESEARCH, INC.

  公开号：EP0727149A2

  公开（公告）日：1996-08-21

  Sweetness inhibitors which are substantially tasteless have been found to be bitter taste inhibitors or blockers. Conversely, bitter taste inhibitors which are substantially tasteless have been found to be sweet taste inhibitors or blockers.

  已发现基本上无味的甜味抑制剂是苦味抑制剂或阻断剂。反之，基本无味的苦味抑制剂被发现是甜味抑制剂或阻断剂。
• Ingestible containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers
  申请人：BIORESEARCH, INC.

  公开号：EP0728419A2

  公开（公告）日：1996-08-28

  Sweetness inhibitors which are substantially tasteless have been found to be bitter taste inhibitors or blockers. Conversely, bitter taste inhibitors which are substantially tasteless have been found to be sweet taste inhibitors or blockers.

  已发现基本上无味的甜味抑制剂是苦味抑制剂或阻断剂。反之，基本无味的苦味抑制剂被发现是甜味抑制剂或阻断剂。
• Enantioselective enzymatic desymmetrization of prochiral 1,3-diols and enzymatic resolution of monoprotected 1,3-diols based on α-tetralone and related multifunctional scaffolds
  作者：Tridib Mahapatra、Tapas Das、Samik Nanda

  DOI：10.1016/j.tetasy.2008.10.024

  日期：2008.11

  Novel multifunctional chemotypes based on alpha-tetralone, alpha-indarione, and chromanone have been synthesized by a chemo-enzymatic approach by applying an enzymatic irreversible transesterification strategy. The scaffolds synthesized can be further elaborated with subsequent enzymatic as well as chemical transformations for the generation of new sets of structurally related organic molecules. (C) 2008 Elsevier Ltd. All rights reserved.
• Birch et al., Journal of the Chemical Society, 1936, p. 1834,1837
  作者：Birch et al.

  DOI：——

  日期：——
• Chemoenzymatic synthesis and resolution of compounds containing a quaternary stereocenters adjacent to a carbonyl group
  作者：Tridib Mahapatra、Nandan Jana、S. Nanda

  DOI：10.1016/j.tetasy.2008.04.024

  日期：2008.5

  Racemic compounds containing a quaternary stereocenter (having hydroxymethyl and alkyl group adjacent to keto functionality) based on chromanone, alpha-tetralone, and indalone scaffolds have been synthesized. An enzymatic irreversible transesterification approach has been applied to generate the pure enantiomers in a stereocontrolled fashion. The pure enantiomers of some alpha,alpha-dialkylated carbonyl compounds have been synthesized by this method. (C) 2008 Elsevier Ltd. All rights reserved.