3-hydroxy-4-methoxy-benzaldehyde (E)-oxime | 51673-94-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-hydroxy-4-methoxy-benzaldehyde (E)-oxime
• 英文别名: 3-hydroxy-4-methoxy-benzaldehyde-oxime；3-Hydroxy-4-methoxy-benzaldehyd-oxim；4-methoxy-3-hydroxybenzaldehyde oxime；5-[(E)-(hydroxyimino)methyl]-2-methoxyphenol；5-[(E)-hydroxyiminomethyl]-2-methoxyphenol
• CAS: 51673-94-0
• 化学式: C₈H₉NO₃
• 分子量: 167.164
• InChiKey: OFECAPSGCJMTFT-WEVVVXLNSA-N

物化性质

• 熔点：
  146.5 °C
• 沸点：
  315.2±32.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  62
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-hydroxy-4-methoxy-benzaldehyde (E)-oxime 在 氢氧化钾 、 alkaline solution 、 硫酸 作用下， 生成 3-羟基-4-甲氧基苯甲酸甲酯
  参考文献：
  名称：

  Aiding chronic written language expression difficulties: A case study

  摘要：

  This paper describes some progress made in helping a young aphasic man (MD) to overcome what had appeared to be intractable written language expression difficulties, which continued to be significant for him. Traditional therapy methods based on cognitive neuropsychological assessment had failed to help MD to generalize improvement in his spelling particularly, but not exclusively, of longer and irregular words. Both a splint which allowed him to use his dominant hand for writing directly onto a computer screen and a simple word-processing programme with synthesized auditory feedback and lexical and grammatical prediction (Write:OutLoud(R) and Co:Writer(R)) enabled him to produce more normal written output (increased quantity and more normal quality). The discussion also focuses on how effectiveness of language therapy can be measured in this man with chronic aphasia.

  DOI：

  10.1080/026870300401612
• 作为产物：
  描述：

  异香兰素 生成 3-hydroxy-4-methoxy-benzaldehyde (E)-oxime
  参考文献：
  名称：

  Aiding chronic written language expression difficulties: A case study

  摘要：

  This paper describes some progress made in helping a young aphasic man (MD) to overcome what had appeared to be intractable written language expression difficulties, which continued to be significant for him. Traditional therapy methods based on cognitive neuropsychological assessment had failed to help MD to generalize improvement in his spelling particularly, but not exclusively, of longer and irregular words. Both a splint which allowed him to use his dominant hand for writing directly onto a computer screen and a simple word-processing programme with synthesized auditory feedback and lexical and grammatical prediction (Write:OutLoud(R) and Co:Writer(R)) enabled him to produce more normal written output (increased quantity and more normal quality). The discussion also focuses on how effectiveness of language therapy can be measured in this man with chronic aphasia.

  DOI：

  10.1080/026870300401612

文献信息

• Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof
  申请人：Tsou Hwei-Ru

  公开号：US20080085890A1

  公开（公告）日：2008-04-10

  This invention provides compounds of Formula (I), having the structure where G 1 , G 2 , G 3 , G 4 , A 1 , A 2 , Y 1 , Y 2 , L 1 , Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.

  这项发明提供了具有结构的化合物（I），其中G1、G2、G3、G4、A1、A2、Y1、Y2、L1、Z、e和f在此处定义，或其药用可接受盐，用于治疗或预防癌症。
• N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF
  申请人：Shi Jiangong

  公开号：US20130045942A1

  公开（公告）日：2013-02-21

  The present invention provides N 6 -substituted adenosine derivatives and N 6 -substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

  本发明提供了N6-取代腺苷衍生物和N6-取代腺嘌呤衍生物，其制备方法，包括上述化合物的药物组合物，以及这些化合物在制造治疗失眠、惊厥、癫痫和帕金森病的药物和保健产品以及预防和治疗痴呆症中的用途。
• Topische kosmetische Mittel, enthaltend Benzaldoxime
  申请人：HAARMANN & REIMER GMBH

  公开号：EP1066821A1

  公开（公告）日：2001-01-10

  Benzaldoxime mit mindestens einer aromatischen Hydroxy- oder Alkoxygruppe sind wirksame Bestandteile in topischen kosmetischen Mittel, insbesondere Hautaufhellungsmittel.

  含有至少一个芳香羟基或烷氧基的苯甲醛肟是外用化妆品的有效成分，尤其是皮肤美白剂。
• N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF
  申请人：INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP2511283A1

  公开（公告）日：2012-10-17

  The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

  本发明提供了 N6-取代腺苷衍生物和 N6-取代腺嘌呤衍生物、其制造方法、包含上述化合物的药物组合物，以及这些化合物在制造治疗失眠、抽搐、癫痫和帕金森病以及预防和治疗痴呆症的药物和保健产品中的用途。
• Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
  申请人：Ions Pharmaceutical S.à r.l.

  公开号：US10092550B2

  公开（公告）日：2018-10-09

  Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.

  人类治疗组合物包含姜黄素成分、禾本科成分和异香兰素成分中的至少两种，最好是三种成分的组合。 这些制剂可有效治疗人类疾病，尤其是人类癌症。