(methyl-2 propene-1 yl)-2 tetrahydrofuranne | 80275-49-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: (methyl-2 propene-1 yl)-2 tetrahydrofuranne
• 英文别名: 2-(2-methylprop-1-en-1-yl)tetrahydrofuran；2-(2-Methylprop-1-enyl)tetrahydrofuran；2-(2-methylprop-1-enyl)oxolane
• CAS: 80275-49-6
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: WIACMJRBMRFAPG-UHFFFAOYSA-N

物化性质

• 沸点：
  136-140 °C
• 密度：
  0.956±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,2-dimethyl-N-(prop-2-ynyl)propionamide 在 dicyclohexyl(12-phenyl-9,10-dihydro-9,10-ethenoanthracen-11-yl)phosphanegold bis(trifluoromethane)sulfonimide 作用下， 以 氘代苯 为溶剂， 以99%的产率得到(methyl-2 propene-1 yl)-2 tetrahydrofuranne
  参考文献：
  名称：

  KITPHOS单膦的金（I）配合物：高效的环异构化催化剂

  摘要：

  Abstractmagnified imageGold(I)‐triflimide (AuNTf2)complexes of H‐KITPHOS and o‐MeO‐KITPHOS have been prepared and shown to be efficient catalysts for a range of intramolecular cyclisations to afford phenols, acylindenes, alkylidene oxazoles, tetrahydropyrans and lactones, in the majority of cases these catalysts are superior to those previously reported.

  DOI：

  10.1002/adsc.200800681

文献信息

• Merging Photoredox and Nickel Catalysis: Decarboxylative Cross-Coupling of Carboxylic Acids with Vinyl Halides
  作者：Adam Noble、Stefan J. McCarver、David W. C. MacMillan

  DOI：10.1021/ja511913h

  日期：2015.1.21

  Decarboxylative cross-coupling of alkyl carboxylic acids with vinyl halides has been accomplished through the synergistic merger of photoredox and nickel catalysis. This new methodology has been successfully applied to a variety of α-oxy and α-amino acids, as well as simple hydrocarbon-substituted acids. Diverse vinyl iodides and bromides give rise to vinylation products in high efficiency under mild

  烷基羧酸与乙烯基卤化物的脱羧交叉偶联是通过光氧化还原和镍催化的协同合并实现的。这种新方法已成功应用于各种α-氧基和α-氨基酸，以及简单的烃取代酸。不同的乙烯基碘化物和溴化物在温和、操作简单的反应条件下高效地产生乙烯基化产物。
• Hydroalkoxylation Catalyzed by a Gold(I) Complex Encapsulated in a Supramolecular Host
  作者：Z. Jane Wang、Casey J. Brown、Robert G. Bergman、Kenneth N. Raymond、F. Dean Toste

  DOI：10.1021/ja202055v

  日期：2011.5.18

  Gold(I)-phosphine complexes are readily encapsulated by a tetrahedral supramolecular host (Ga(4)L(6)). We have investigated the catalytic activity of the resulting complexes for the intramolecular hydroalkoxylation of allenes. The catalytic activity of Me(3)PAuBr was increased 8-fold by encapsulation, as determined by initial rate kinetics, and we observed up to 67 catalytic turnovers by Me(3)PAu(+)

  金 (I)-膦配合物很容易被四面体超分子宿主 (Ga(4)L(6)) 封装。我们研究了所得配合物对丙二烯分子内加氢烷氧基化的催化活性。由初始速率动力学确定，Me(3)PAuBr 的催化活性通过封装增加了 8 倍，我们观察到封装在 Ga(4)L(6) 中的 Me(3)PAu(+) 催化转化率高达 67 ）。
• [EN] BORONATES AS ARGINASE INHIBITORS<br/>[FR] BORONATES EN TANT QU'INHIBITEURS D'ARGINASE
  申请人：MARS INC

  公开号：WO2012058065A1

  公开（公告）日：2012-05-03

  Compounds according to Formula I are potent inhibitors of Arginase I and II activity: (I) where R1, R2, R3, R4, D, W, X, Y, and Z are defined in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use in treating or preventing a disease or a condition associated with arginase activity.

  根据公式I，化合物是Arginase I和II活性的有效抑制剂：(I)其中R1、R2、R3、R4、D、W、X、Y和Z在说明书中有定义。该发明还提供了这些化合物的药物组合物以及它们在治疗或预防与Arginase活性相关的疾病或病况的方法。
• [EN] INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS<br/>[FR] INHIBITEURS D'ARGINASE ET LEURS APPLICATIONS THÉRAPEUTIQUES
  申请人：MARS INC

  公开号：WO2011133653A1

  公开（公告）日：2011-10-27

  Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity : Formule (I), (II) where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.

  根据式I和式II，化合物是Arginase I和II活性的强效抑制剂：式(I)，(II)中的R1、R2、R3、R4、R5、R6、R7、R8、R9、D、M、X和Y的定义如规范所述。该发明还提供了这些化合物的药物组合物以及它们用于治疗或预防与Arginase活性相关的疾病或病况的方法。
• [EN] RNA-FOCUSED SMALL MOLECULES FOR INHIBITING RNA TOXICITY IN MYOTONIC DYSTROPHY<br/>[FR] PETITES MOLÉCULES FOCALISÉES SUR L'ARN POUR INHIBER LA TOXICITÉ DE L'ARN DANS LA DYSTROPHIE MYOTONIQUE
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2017049165A1

  公开（公告）日：2017-03-23

  The invention provides compounds and their pharmaceutical compositions according to Formula (I) that are useful for inhibiting RNA toxicity, such as in the treatment of myotonic dystrophy type 1, wherein W1, W2, W3, W4, L1, L2, and Cy are defined herein.

  该发明提供了根据式（I）的化合物及其药物组合物，用于抑制RNA毒性，例如在治疗肌萎缩性脱髓鞘疾病类型1方面，其中W1、W2、W3、W4、L1、L2和Cy在此处被定义。