5-Hydroxy-1,4-dimethylpyrrolidin-2-one | 67311-07-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 5-Hydroxy-1,4-dimethylpyrrolidin-2-one
• CAS: 67311-07-3
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: WNLXJZKCHBMHNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-Hydroxy-1,4-dimethylpyrrolidin-2-one 、 1-甲基-1-苯肼 在 吡啶盐酸盐 作用下， 生成 1,3a,8-trimethyl-3,3a,8,8a-tetrahydro-1H-pyrrolo[2,3-b]indol-2-one
  参考文献：
  名称：

  Isoeserin und homoisoeserin, darstellung und strukturaufklärung des indolo-1, 3-diazepin-systems

  摘要：

  DOI：

  10.1016/s0040-4039(01)80322-1
• 作为产物：
  描述：

  1,3-二甲基吡咯烷-2,5-二酮 在 sodium tetrahydroborate 、 copper dichloride 作用下， 以 乙醇 为溶剂， 生成 5-Hydroxy-1,3-dimethylpyrrolidin-2-one 、 5-Hydroxy-1,4-dimethylpyrrolidin-2-one
  参考文献：
  名称：

  Isoeserin und homoisoeserin, darstellung und strukturaufklärung des indolo-1, 3-diazepin-systems

  摘要：

  DOI：

  10.1016/s0040-4039(01)80322-1

文献信息

• Di-or tripeptide renin inhibitors containing lactam conformational restrictions in ACHPA
  申请人：Merck & Co., Inc.

  公开号：EP0312283A2

  公开（公告）日：1989-04-19

  Enzyme di- or tripeptides of the formula: and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptides.

  式中的酶二肽或三肽： 及其类似物，它们能抑制肾素，可用于治疗各种形式的肾素相关性高血压、高醛固酮症和充血性心力衰竭；含有这些肾素抑制肽的组合物，可选择与其它降压药一起使用；以及治疗高血压、高醛固酮症或充血性心力衰竭的方法，或确定肾素是这些问题的致病因素的方法，这些方法都采用了这些新型肽。
• WIJNBERG J. B. P. A.; SCHOEMAKER H. E.; SPECKAMP W. N., TETRAHEDRON <TETR-AB>, 1978, 34, NO 2, 179-187
  作者：WIJNBERG J. B. P. A.、 SCHOEMAKER H. E.、 SPECKAMP W. N.

  DOI：——

  日期：——
• POLYMER COMPOSITIONS CONTAINING AN ULTRAVIOLET LIGHT ABSORBING COMPOUND
  申请人：EASTMAN CHEMICAL COMPANY

  公开号：EP1599532B1

  公开（公告）日：2017-05-17
• COMPOUND OR ITS TAUTOMER, METAL COMPLEX COMPOUND, COLORED PHOTOSENSITIVE CURING COMPOSITION, COLOR FILTER, AND PRODUCTION
  申请人：MIZUKAWA Yuki

  公开号：US20100230647A1

  公开（公告）日：2010-09-16

  The invention provides a colored photosensitive curing composition useful for color filters in primary colors, including blue, green, and red, having a high molar absorption coefficient and allowing a reduction in film thickness and superior color purity and fastness; the colored photosensitive curing composition including, as its colorant, a dipyrromethene-based metal complex compound or a interconvertible isomer thereof, obtained from a metal or metal compound and a dipyrromethene-based compound represented by Formula (III): wherein R 2 to R 5 , R 7 represent a hydrogen atom or a substituent group; Ma represents a metal or metal compound; X 3 represents NR, a nitrogen, oxygen or sulfur atom; X 4 represents NR, an oxygen or sulfur atom; Y 1 represents NR, a nitrogen or carbon atom; Y 2 represents a nitrogen or carbon atom; R 8 and R 9 represent a substituent group; X 5 represents a group that can bond to Ma; and a is 0, 1, or 2.
• US5006511A
  申请人：——

  公开号：US5006511A

  公开（公告）日：1991-04-09