(2E,4E)-2-cyano-N-cyclohexyl-5-phenylpenta-2,4-dienamide | 1137951-56-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2E,4E)-2-cyano-N-cyclohexyl-5-phenylpenta-2,4-dienamide
• CAS: 1137951-56-4
• 化学式: C₁₈H₂₀N₂O
• 分子量: 280.37
• InChiKey: ZRJNSSLEISOTLH-RWZRJOGJSA-N

物化性质

• 沸点：
  522.4±50.0 °C(predicted)
• 密度：
  1.10±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二溴丙二酸二乙酯 、 (2E,4E)-2-cyano-N-cyclohexyl-5-phenylpenta-2,4-dienamide 在 锌 、 六甲基磷酰三胺 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 以78%的产率得到ethyl 3-cyclohexyl-5-cyano-2,4-dioxo-6-(2-phenylvinyl)-3-azabicyclo[3.1.0]hexane-1-carboxylate
  参考文献：
  名称：

  Reaction of organozinc reagents formed from α,α-dibromocarbonyl compounds and zinc with (3-phenylprop-2-enylidene)malonodinitriles and primary amides of 2-Cyano-5-phenylpenta-2,4-dienoic acid

  摘要：

  Organozinc compounds formed from I-aryi-2,2-dibromoalkanes, a,a-dibromopinacoline, and dialkyl dibromomalonates and zinc react with (3-phenylprop-2-enylidene)inalonodinitriles and primary amides of 2-cyano-5-phenylpenta-2.4-dienoic acid to form 2-alkyl-2-aroyl-3-(phenylvinyl)cyclopropan-1,1dicarboxylic acid dinitriles, N-substituted amides of 3-(phenylvinyl)-2-(2,2-dimethylpropanoyl)-lcyanocyclopropan-l-carboxylic acids, and alkyl 3-R-6-(phenylvinyl)-2.4-dioxo-5-cyano-3-azabicyclo[3.1.01hexan- I -carboxylates as a single stereoisomer.

  DOI：

  10.1134/s1070363208060145

文献信息

• Reaction of organozinc reagents formed from α,α-dibromocarbonyl compounds and zinc with (3-phenylprop-2-enylidene)malonodinitriles and primary amides of 2-Cyano-5-phenylpenta-2,4-dienoic acid
  作者：V. V. Shchepin、Yu. G. Stepanyan、S. V. Romashev、P. S. Silaichev

  DOI：10.1134/s1070363208060145

  日期：2008.6

  Organozinc compounds formed from I-aryi-2,2-dibromoalkanes, a,a-dibromopinacoline, and dialkyl dibromomalonates and zinc react with (3-phenylprop-2-enylidene)inalonodinitriles and primary amides of 2-cyano-5-phenylpenta-2.4-dienoic acid to form 2-alkyl-2-aroyl-3-(phenylvinyl)cyclopropan-1,1dicarboxylic acid dinitriles, N-substituted amides of 3-(phenylvinyl)-2-(2,2-dimethylpropanoyl)-lcyanocyclopropan-l-carboxylic acids, and alkyl 3-R-6-(phenylvinyl)-2.4-dioxo-5-cyano-3-azabicyclo[3.1.01hexan- I -carboxylates as a single stereoisomer.