2-(2-iodophenyl)-N-methylethylamine | 881538-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-iodophenyl)-N-methylethylamine
• 英文别名: N-methyl-2-(2-iodophenyl)ethylamine；N-methyl-o-iodo-β-phenethylamine；[2-(2-iodo-phenyl)-ethyl]-methyl-amine；Benzeneethanamine, 2-iodo-N-methyl-；2-(2-iodophenyl)-N-methylethanamine
• CAS: 881538-16-5
• 化学式: C₉H₁₂IN
• 分子量: 261.105
• InChiKey: BSTPKKWTQDFQCS-UHFFFAOYSA-N

物化性质

• 沸点：
  284.5±15.0 °C(Predicted)
• 密度：
  1.539±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2-iodophenyl)-N-methylethylamine 在 正丁基锂 、 methyloxirane 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 正己烷 为溶剂， 反应 6.0h， 生成 1-hydroxy-3-methyl-1,2-diphenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
  参考文献：
  名称：

  Synthesis of New 1,2-Diphenyl-4,5-dihydro-3H-3-benzazepines

  摘要：

  DOI：

  10.3987/com-06-10853
• 作为产物：
  描述：

  2-碘苯甲基溴 在 4 A molecular sieve 、 硼烷 、 potassium carbonate 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 5.0h， 生成 2-(2-iodophenyl)-N-methylethylamine
  参考文献：
  名称：

  A New Synthesis of Phenolic 1-Hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines

  摘要：

  DOI：

  10.3987/com-05-10554

文献信息

• AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS
  申请人：Zhou Dahui

  公开号：US20090069370A1

  公开（公告）日：2009-03-12

  The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.

  本发明提供了一种公式I的化合物，以及该化合物用于治疗与组胺-3受体相关或受其影响的中枢神经系统疾病。
• Synthesis and Pharmacological Evaluation of New 1-Hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as Norepinephrine Potentiators
  作者：Miyuki Ikeuchi、Masako Ikuta、Miyuki Hariki、Motoki Ikeuchi、Shigeki Maruyama、Mari Nakase、Kumiko Sakamoto、Yasuko Yoshioka、Aiko Yamauchi、Masaru Kihara

  DOI：10.1248/cpb.57.443

  日期：——

  4-Hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (PI-OH) (1a) and its derivatives form a new class of compounds which possess norepinephrine (NE) potentiating activity. As a new series of compounds, 1-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines (2a—f) were synthesized by the intramolecular Barbier reaction of N-[2-(2-iodophenyl)ethyl]phenacylamines (6a—f) with n-BuLi as a key reaction step. The potentiating activities of the benzazepines 2a—f on the contraction of rat anococcygeus muscle induced by NE were tested. Among the compounds tested in this study, compound 2a showed moderate potentiating activity (the activity ratio was 7.3-fold at 3×10−5 M).

  4-羟基-2-甲基-4-苯基-1,2,3,4-四氢异喹啉 (PI-OH) (1a) 及其衍生物形成一类具有去甲肾上腺素 (NE) 增强活性的新型化合物。作为一系列新化合物，通过N-[2-(2 -碘苯基）乙基]苯甲酰胺（6a-f），以正丁基锂为关键反应步骤。测试了苯并氮杂卓2a-f对NE诱导的大鼠尾尾肌收缩的增强活性。在本研究测试的化合物中，化合物2a表现出中等的增强活性（3×10−5 M时活性比为7.3倍）。
• Radioiodine containing amines, their preparation and their use as brain imaging agents
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0011858A1

  公开（公告）日：1980-06-11

  Certain radioiodine containing amines useful as brain imaging agents as well as their preparation are disclosed. The compounds of the invention are represented by the formula Wherein I is a radioisotope of iodine with 1-123 being preferred, R is lower alkyl or halogen, R and R2 are the same or different and are selected from the group consisting of hydrogen and lower alkyl, R3 and R4 are the same or different and are selected from the group consisting of hydrogen, alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl and substituted carbamoylmethyl or R3 and R4 taken together with the nitrogen to which they are attached form a 5- or 6-membered ring which may be substituted with one or more lower alkyl groups, x is 0 to 4, y is 0 to 3 and z is 0 or 1, and pharmaceutically acceptable acid addition salts thereof.

  本发明公开了某些可用作脑成像剂的含放射性碘胺及其制备方法。本发明的化合物由式表示 其中，I 是碘的放射性同位素，优选 1-123；R 是低级烷基或卤素；R 和 R2 相同或不同，且选自由氢和低级烷基组成的组；R3 和 R4 相同或不同，且选自由氢、烷基、芳基、取代芳基、芳烷基、取代芳烷基和取代氨基甲酰基组成的组、或 R3 和 R4 与它们所连接的氮一起形成可被一个或多个低级烷基取代的 5 或 6 元环，x 为 0 至 4，y 为 0 至 3，z 为 0 或 1，以及它们的药学上可接受的酸加成盐。
• CHIRALE CYCLOPLATINIERTE KOMPLEXE, HERSTELLUNGSVERFAHREN SOWIE DEREN VERWENDUNG IN MEDIZIN UND KATALYSE
  申请人：Rheinisch-Westfälisch-Technische Hochschule Aachen

  公开号：EP2220100A2

  公开（公告）日：2010-08-25
• METHOD FOR PRODUCING CYCLOPLATINIZED PLATINUM COMPLEXES, PLATINUM COMPLEXES PRODUCED BY SAID METHOD, AND THE USE THEREOF
  申请人：Englert Ullrich

  公开号：US20100267977A1

  公开（公告）日：2010-10-21

  The present invention relates to a process for preparing cycloplatinated platinum(II) complexes, platinum(II) complexes prepared by this process and the use thereof for the treatment of tumor diseases and/or hemo blastoses.