(E)-3-(1,3,6,2-dioxazaborocan-2-yl)-N-methoxy-1-phenylpropan-1-imine | 316821-53-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-3-(1,3,6,2-dioxazaborocan-2-yl)-N-methoxy-1-phenylpropan-1-imine
• CAS: 316821-53-1
• 化学式: C₁₄H₂₁BN₂O₃
• 分子量: 276.143
• InChiKey: ORRJYSKNAJAWIZ-SAPNQHFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.55
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (E)-3-(1,3,6,2-dioxazaborocan-2-yl)-N-methoxy-1-phenylpropan-1-imine 在 盐酸 、 dimethyl sulfide borane 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 16.0h， 生成 3-acetylamino-3-phenylpropyl acetate
  参考文献：
  名称：

  ‘Transmitted’ remote double diastereoselection effects on the asymmetric reduction of β-boronate oxime ethers

  摘要：

  Remote asymmetric induction in the reduction of a homochiral beta-boronate oxime ether to the corresponding amine failed to provide asymmetric induction with achiral reducing agents, but use of a chiral reducing agent produced extreme double diastereoselection effects which show that remote asymmetry can be 'transmitted' by suitable choice of a 'partner' molecule. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00179-9
• 作为产物：
  描述：

  (E)-acetophenone O-methyloxime 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 (E)-3-(1,3,6,2-dioxazaborocan-2-yl)-N-methoxy-1-phenylpropan-1-imine
  参考文献：
  名称：

  ‘Transmitted’ remote double diastereoselection effects on the asymmetric reduction of β-boronate oxime ethers

  摘要：

  Remote asymmetric induction in the reduction of a homochiral beta-boronate oxime ether to the corresponding amine failed to provide asymmetric induction with achiral reducing agents, but use of a chiral reducing agent produced extreme double diastereoselection effects which show that remote asymmetry can be 'transmitted' by suitable choice of a 'partner' molecule. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00179-9

文献信息

• ‘Transmitted’ remote double diastereoselection effects on the asymmetric reduction of β-boronate oxime ethers
  作者：Helen E. Sailes、John P. Watts、Andrew Whiting

  DOI：10.1016/s0040-4039(00)00179-9

  日期：2000.4

  Remote asymmetric induction in the reduction of a homochiral beta-boronate oxime ether to the corresponding amine failed to provide asymmetric induction with achiral reducing agents, but use of a chiral reducing agent produced extreme double diastereoselection effects which show that remote asymmetry can be 'transmitted' by suitable choice of a 'partner' molecule. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.