2-methyl-6-phenylheptan-4-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-6-phenylheptan-4-ol
• 化学式: C₁₄H₂₂O
• 分子量: 206.328
• InChiKey: FOKZVHHSWXDZBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-methyl-6-phenylheptan-4-ol 在 甲酸 、 氯磺酰异氰酸酯 作用下， 以 N,N-二甲基乙酰胺 、 乙腈 为溶剂， 反应 1.0h， 以77%的产率得到
  参考文献：
  名称：

  Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination

  摘要：

  The development of readily tunable and regioselective C-H functionalization reactions that operate solely through catalyst control remains a challenge in modern organic synthesis. Herein, we report that simple silver catalysts supported by common nitrogenated ligands can be used to tune a nitrene transfer reaction between two different types of C-H bonds. The results reported herein represent the first example of ligand-controlled and site-selective silver-promoted C-H amination.

  DOI：

  10.1021/ja5094309
• 作为产物：
  描述：

  溴代异丁烷 、 3-苯基丁醛 在 magnesium 、 盐酸 作用下， 以 乙醚 、 水 为溶剂， 反应 1.5h， 以64%的产率得到2-methyl-6-phenylheptan-4-ol
  参考文献：
  名称：

  Ligand-Controlled, Tunable Silver-Catalyzed C–H Amination

  摘要：

  The development of readily tunable and regioselective C-H functionalization reactions that operate solely through catalyst control remains a challenge in modern organic synthesis. Herein, we report that simple silver catalysts supported by common nitrogenated ligands can be used to tune a nitrene transfer reaction between two different types of C-H bonds. The results reported herein represent the first example of ligand-controlled and site-selective silver-promoted C-H amination.

  DOI：

  10.1021/ja5094309

文献信息

• Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes
  作者：Yan-Long Zheng、Yan-Yao Liu、Yi-Mei Wu、Yin-Xia Wang、Yu-Tong Lin、Mengchun Ye

  DOI：10.1002/anie.201602130

  日期：2016.5.17

  An FeBr3‐catalyzed reductive coupling of various aldehydes with alkenes that proceeds through a direct hydride transfer pathway has been developed. With iPrOH as the hydrogen donor under mild conditions, previously challenging coupling reactions of unactivated alkyl and aryl aldehydes with simple alkenes, such as styrene derivatives and α‐olefins, proceeded smoothly to furnish a diverse range of functionalized

  已经开发出FeBr 3催化的通过直接氢化物转移途径进行的各种醛与烯烃的还原偶联。以i PrOH作为氢供体在温和的条件下，以前挑战性的未活化烷基和芳基醛与简单烯烃（如苯乙烯衍生物和α-烯烃）的偶合反应顺利进行，以提供具有完全线性区域选择性的各种官能化醇。
• Tunable differentiation of tertiary C–H bonds in intramolecular transition metal-catalyzed nitrene transfer reactions
  作者：Joshua R. Corbin、Jennifer M. Schomaker

  DOI：10.1039/c7cc01235g

  日期：——

  Metal-catalyzed nitrene transfer reactions are an appealing and efficient strategy for accessing tetrasubstituted amines through the direct amination of tertiary C-H bonds.

  金属催化的氮烯转移反应是通过叔 CH 键的直接胺化获得四取代胺的一种有吸引力且有效的策略。