methyl N-(4-chloro-5-cyclopentyloxy-2-fluorophenyl)carbamate | 141772-41-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl N-(4-chloro-5-cyclopentyloxy-2-fluorophenyl)carbamate
• 英文别名: methyl N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)carbamate；methyl N-(2-fluoro4-chloro-5-cyclopentyloxyphenyl)carbamate
• CAS: 141772-41-0
• 化学式: C₁₃H₁₅ClFNO₃
• 分子量: 287.718
• InChiKey: FFRRKQUHSRSSSC-UHFFFAOYSA-N

物化性质

• 沸点：
  337.6±42.0 °C(Predicted)
• 密度：
  1.345±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl N-(4-chloro-5-cyclopentyloxy-2-fluorophenyl)carbamate 在 氢氧化钾 作用下， 以 乙醇 、 水 为溶剂， 以98.3%的产率得到2-fluoro-4-chloro-5-cyclopentyloxyaniline
  参考文献：
  名称：

  Process for the production of aniline derivatives

  摘要：

  高效生产苯胺衍生物的工业过程，这些衍生物是制造噁唑烷二酮衍生物和四氢邻苯二甲酰亚胺衍生物的重要中间体，后者作为除草剂的活性成分。该过程从2,4-二卤-5-氨基酚或双(2,4-二卤-5-氨基苯基)碳酸酯开始，并在不保护氨基的情况下选择性地使羟基发生环烷基化或炔基化反应，从而可以高产率地生产具有环烷氧基或炔氧基的苯胺衍生物。

  公开号：

  US05639915A1
• 作为产物：
  描述：

  溴代环戊烷 、 methyl N-(2-fluoro-4-chloro-5-hydroxyphenyl)carbamate 在 盐酸 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 methyl N-(4-chloro-5-cyclopentyloxy-2-fluorophenyl)carbamate
  参考文献：
  名称：

  Bis(fluorophenyl) carbonate derivatives

  摘要：

  揭示了氟苯衍生物，这些衍生物是生产除草草酰胺二酮衍生物的重要中间体，并且揭示了生产它们的方法。氟苯衍生物包括具有以下结构的化合物（11）：其中X是卤素原子，R.sup.3是硝基、氨基或异氰酸基或R.sup.1 OCONH，R.sup.1是烷基或苯基。通过本发明的中间体，可以高产率地生产草酰胺二酮衍生物。

  公开号：

  US05281742A1

文献信息

• Tetrahydrophthalamide derivative, intermediate for producing the same,
  申请人：Sagami Chemical Research Center

  公开号：US05506190A1

  公开（公告）日：1996-04-09

  The present invention relates to 3,4,5,6-tetrahydrophthalamide derivatives and 3,4,5,6-tetrahydroisophthalimide derivatives having excellent effects as effective active ingredients of herbicides, and processes for preparing the same, and provides the compounds having a more efficient herbicidal activity, and efficient and industrial processes for the preparation thereof. More specifically, the tetrahydrophthalimide derivative obtained by reacting a halogen-substituted 5-cycloalkyloxyaniline derivative with a 3,4,5,6-tetrahydrophthalic anhydride, or the tetrahydroisophthalimide derivative of the present invention is reacted with various types of amines to prepare a tetrahydrophthalamide derivative represented by the general formula (I): ##STR1## These tetrahydrophthalamide derivatives and the tetrahydroisophthalimide derivatives exhibit excellent herbicidal activities in the soil treatment in the paddy field and field and the stem-foliar treatment. The tetrahydroisophthalimide derivatives are also useful as intermediates for the preparation of the tetrahydrophthalamide derivatives, etc.

  本发明涉及具有卓越除草剂有效活性成分的3,4,5,6-四氢邻苯二酰胺衍生物和3,4,5,6-四氢异苯二酰胺衍生物，以及其制备方法，并提供具有更高效的除草活性的化合物，以及其高效和工业化的制备方法。更具体地，通过将卤素取代的5-环烷氧基苯胺衍生物与3,4,5,6-四氢邻苯二酐反应获得的四氢邻苯二酰胺衍生物，或者将本发明的四氢异苯二酰胺衍生物与各种类型的胺反应以制备由通式（I）表示的四氢邻苯二酰胺衍生物：这些四氢邻苯二酰胺衍生物和四氢异苯二酰胺衍生物在稻田和田间土壤处理以及茎叶处理中表现出卓越的除草活性。四氢异苯二酰胺衍生物还可用作制备四氢邻苯二酰胺衍生物等的中间体。
• Process for the preparation of 3-(substituted
  申请人：Sagami Chemical Research Center

  公开号：US06090946A1

  公开（公告）日：2000-07-18

  The present invention provides an industrial process for efficiently preparing a 3-(substituted phenyl)-5-isopropylidene-1,3-oxazolidine-2,4-dione derivative having a potent herbicidal activity without using phosgene or the like. The present invention relates to a process for preparing a 3-(substituted phenyl)-5-alkylidene-1,3-oxazolidine-2,4-dione derivative represented by general formula (III), which comprises reaction of an N-(substituted phenyl)carbamate represented by general formula (I) with a 2-hydroxy-3-alkenoate represented by-general formula (II) or with a 3-alkoxy-2-hydroxyalkanoate represented by general formula (IV): ##STR1## (wherein Ar is a substituted phenyl group, R.sup.1 is an alkyl group having a carbon number of from 1 to 6, R.sup.2 and R.sup.3 are independently hydrogen atoms or alkyl groups having carbon numbers of from 1 to 12, and R.sup.4 and R.sup.5 are independently alkyl groups having carbon numbers of from 1 to 6).

  本发明提供了一种工业过程，用于高效制备具有强大除草活性的3-(取代苯基)-5-异丙基亚甲基-1,3-噁唑烷-2,4-二酮衍生物，而不使用光气等。本发明涉及一种制备3-(取代苯基)-5-烷基亚甲基-1,3-噁唑烷-2,4-二酮衍生物的过程，该衍生物由通式(III)表示，其中包括将通式(I)表示的N-(取代苯基)氨基甲酸酯与通式(II)表示的2-羟基-3-烯酸酯或通式(IV)表示的3-烷氧基-2-羟基烷酸酯反应：##STR1##（其中Ar是取代苯基，R^1是碳数为1至6的烷基，R^2和R^3分别是氢原子或碳数为1至12的烷基，R^4和R^5分别是碳数为1至6的烷基）。
• Methods of preparing fluorobenzene derivatives and related compounds
  申请人：Sagami Chemical Research Center

  公开号：US05391807A1

  公开（公告）日：1995-02-21

  Disclosed are fluorobenzene derivatives, which are important intermediates for producing herbicidal oxazolidinedione derivatives, and methods of producing them. The fluorobenzene derivatives include compounds of a formula (11): ##STR1## where X is a halogen atom, R.sup.3 is a nitro, amino or isocyanato group or R.sup.1 OCONH, and R.sup.1 is an alkyl or phenyl group. Via the intermediates of the invention, oxazolidinedione derivatives can be produced with high yield.

  本发明公开了氟苯衍生物及其制备方法。这些氟苯衍生物是生产除草剂噁唑烷二酮衍生物的重要中间体。所述氟苯衍生物包括公式（11）的化合物：##STR1## 其中X是卤素原子，R.sup.3是硝基、氨基或异氰酸基或R.sup.1 OCONH，而R.sup.1是烷基或苯基。通过本发明的中间体，可以高产地生产噁唑烷二酮衍生物。
• Benzene derivatives substituted with heterocyclic ring and herbicides
  申请人：Sagami Chemical Research Center

  公开号：US05464811A1

  公开（公告）日：1995-11-07

  A benzene derivative substituted with a heterocyclic ring represented by the general formula: ##STR1## wherein R represents a cycloalkyl group having 3 to 8 carbon atoms, X represents a halogen atom, and Z represents ##STR2## in which said cycloalkyl group may be substituted with an alkyl group having 1 to 6 carbon atoms, a process for preparing the same, and a herbicidal agent comprising the above compound as an active ingredient are disclosed. The compound has an excellent effect in that the compound exhibits a markedly high herbicidal effect on weeds in the field and the paddy field at a low dose and yet exhibits markedly low noxious effects on main crops.

  本发明涉及一种苯衍生物，其被杂环环代替，通式如下：##STR1## 其中，R代表具有3至8个碳原子的环烷基，X代表卤素原子，Z代表##STR2## 其中，所述环烷基可以被具有1至6个碳原子的烷基取代。本发明还涉及一种制备上述化合物的方法以及包含上述化合物作为活性成分的除草剂。该化合物具有显著的效果，因为该化合物在低剂量下对田间和稻田中的杂草表现出显著的高除草效果，并且对主要农作物的有害影响显著降低。
• Fluorobenzene derivatives
  申请人：Sagami Chemical Research Center

  公开号：US05344953A1

  公开（公告）日：1994-09-06

  Disclosed are fluorobenzene derivatives, which are important intermediates for producing herbicidal oxazolidinedione derivatives, and methods of producing them. The fluorobenzene derivatives include compounds of a formula (11): ##STR1## where X is a halogen atom, R.sup.3 is a nitro, amino or isocyanato group or R.sup.1 OCONH, and R.sup.1 is an alkyl or phenyl group. Via the intermediates of the invention, oxazolidinedione derivatives can be produced with high yield.

  本发明公开了一种氟苯衍生物，其是制备除草剂噁唑烷二酮衍生物的重要中间体，并公开了制备它们的方法。所述氟苯衍生物包括式（11）的化合物：##STR1## 其中X为卤素原子，R.sup.3为硝基，氨基或异氰酸基或R.sup.1OCONH，R.sup.1为烷基或苯基。通过本发明的中间体，可以高产得到噁唑烷二酮衍生物。