2,3-Diacetoxy-anisol | 111211-64-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2,3-Diacetoxy-anisol
• 英文别名: (2-Acetyloxy-3-methoxyphenyl) acetate
• CAS: 111211-64-4
• 化学式: C₁₁H₁₂O₅
• 分子量: 224.213
• InChiKey: LKUFCKMSZCIWEF-UHFFFAOYSA-N

物化性质

• 熔点：
  92.5-93 °C(Solv: ethanol (64-17-5))
• 沸点：
  300.9±32.0 °C(Predicted)
• 密度：
  1.188±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,3-Diacetoxy-anisol 在 碘 、 silver trifluoroacetate 作用下， 生成 3-iodo-6-methoxy-1,2-phenylene diacetate
  参考文献：
  名称：

  WO2007/87684

  摘要：

  公开号：
• 作为产物：
  描述：

  3-甲氧基儿茶酚 生成 2,3-Diacetoxy-anisol
  参考文献：
  名称：

  Herzig; Pollak, Monatshefte fur Chemie, 1904, vol. 25, p. 513

  摘要：

  DOI：

文献信息

• An efficient method to prepare aryl acetates by the carbonylation of aryl methyl ethers or phenols
  作者：Dejin Zhang、Guoqiang Yang、Junping Xiong、Jia Liu、Xingbang Hu、Zhibing Zhang

  DOI：10.1039/d0nj05050d

  日期：——

  Synthesis of valuable chemicals from lignin based compounds is critical for the application of biomass. Here, we develop a method of preparing aryl acetates by the carbonylation of aryl methyl ethers or phenols under low CO pressure. Good to excellent yields of aryl acetates were obtained using different substrates, and a possible reaction mechanism was proposed by conducting a series of control experiments

  从木质素基化合物合成有价值的化学物质对于生物质的应用至关重要。在这里，我们开发了一种在低CO压力下通过芳基甲基醚或苯酚的羰基化制备乙酸芳基酯的方法。使用不同的底物可获得良好至优异的乙酸芳基酯收率，并通过进行一系列对照实验提出了可能的反应机理。该方法可提供利用木质素的潜在途径。
• Preparation of amides from an acid and amine for intermediates in the synthesis of morphinans
  申请人：Mallinckrodt Inc.

  公开号：EP2177504A1

  公开（公告）日：2010-04-21

  The present invention is directed to processes for the synthesis of morphinans. In particular, a process for coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl3 that is necessary to form the 3,4-dihydroisoquinoline.

  本发明涉及吗啡类化合物的合成工艺。特别是一种将羧酸化合物与胺化合物偶联形成酰胺产物的工艺，该酰胺产物可以分离出来，或者将粗酰胺产物环化形成3,4-二氢异喹啉。在一个实施方案中，羧酸含有一个用易变保护基团保护的苯酚分子。受保护的苯酚可缩短反应时间，简化产品的加工，并减少形成 3,4-二氢异喹啉所需的环化剂 POCl3 的用量。
• Process for the preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans
  申请人：Mallinckrodt Inc.

  公开号：EP2161253A2

  公开（公告）日：2010-03-10

  The present invention is directed to processes for the synthesis of morphinans. In particular, a process tor coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl3 that is necessary to form the 3,4-dihydroisoquinoline.

  本发明涉及吗啡类化合物的合成工艺。特别是一种将羧酸化合物与胺化合物偶联形成酰胺产物的工艺，这种酰胺产物可以分离出来，或者将粗酰胺产物环化形成 3,4-二氢异喹啉。在一个实施方案中，羧酸含有一个用易变保护基团保护的苯酚分子。受保护的苯酚可缩短反应时间，简化产品的加工，并减少形成 3,4-二氢异喹啉所需的环化剂 POCl3 的用量。
• Preparation and properties of chloro-3-methoxycatechols-components of pulp bleaching effluents
  作者：Terrence J. Smith、Ross H. Wearne、Adrian F.A. Wallis

  DOI：10.1016/0045-6535(94)90008-6

  日期：1994.3

  The preparation and properties are given for the seven chlorinated 3-methoxycatechols, several of which have been reported as components of pulp bleaching effluents. The 4- and 6-substituted compounds and the trichloro-3-methoxycatechol were obtained by direct chlorination of the parent catechol or its diacetate. The 5-substituted compound was prepared by the known addition of hydrochloric acid to 3-methoxy-ortho-benzoquinone, and further chlorination gave the 4,5- and 5,6-dichloro isomers. The diacetates of all seven compounds were separated by gas chromatography. Electron impact mass spectra and H-1 and C-13 NMR data for the diacetates are given.
• Mauthner, Journal fur praktische Chemie (Leipzig 1954), 1938, vol. <2> 150, p. 257,260
  作者：Mauthner

  DOI：——

  日期：——