2-甲氧基-2-苯基-1-氧杂-螺[2.5]辛烷 | 15817-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-甲氧基-2-苯基-1-氧杂-螺[2.5]辛烷
• 英文名称: 2-methoxy-2-phenyl-1-oxa-spiro[2.5]octane
• 英文别名: 2-Methoxy-2-phenyl-1-oxa-spiro[2.5]octan；2-Methoxy-2-phenyl-1-oxaspiro<2.5>octan；Methyl 2-phenyl-1-oxaspiro[2.5]oct-2-yl ether；2-methoxy-2-phenyl-1-oxaspiro[2.5]octane
• CAS: 15817-28-4
• 化学式: C₁₄H₁₈O₂
• 分子量: 218.296
• InChiKey: GYGHIMLKIFGIPK-UHFFFAOYSA-N

物化性质

• 沸点：
  97-100 °C(Press: 0.4 Torr)
• 密度：
  1.052 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-甲氧基-2-苯基-1-氧杂-螺[2.5]辛烷 以 Petroleum ether 为溶剂， 生成 (1-hydroxy-cyclohexyl)-phenyl ketone-dimethylacetal
  参考文献：
  名称：

  氨基酮类化合物的合成及其抗鸟嘌呤活性。

  摘要：

  DOI：

  10.1002/jps.2600540114
• 作为产物：
  描述：

  N2-环己亚基苯甲酰肼 在 sodium acetate 作用下， 以 苯 为溶剂， 生成 2-甲氧基-2-苯基-1-氧杂-螺[2.5]辛烷
  参考文献：
  名称：

  Electrooxidative cyclization of N-acylhydrazones of aldehydes and ketones to .DELTA.3-1,3,4-oxadiazolines and 1,3,4-oxadiazoles

  摘要：

  The electrolytic oxidation of ketone N-acylhydrazones (1) in methanolic sodium acetate induced their intramolecular cyclization to the corresponding 2-methoxy-DELTA(3)-1,3,4-oxadiazolines 3. The thermal stability of a given oxadiazoline and what products were formed by its thermal decomposition was found to depend on the natures of the substituents at C-2. Thus, 2-methoxy-2-phenyloxadiazolines preferentially yielded oxiranes 5, whereas 2-alkyl-2-methoxyoxadiazolines preferentially gave enol ethers 6. 2,2-Dimethoxyoxadiazolines decomposed to the parent ketones and many unidentified products. The electrolytic oxidation of aldehyde N-acylhydrazones 2 gave 2,5-disubstituted 1,3,4-oxadiazoles 4. The oxidative cyclization of the N-benzoylhydrazones of aliphatic aldehydes gave especially high yields of the corresponding heterocycles.

  DOI：

  10.1021/jo00031a014

文献信息

• Epoxyethers. IX. Acid-catalyzed Rearrangements¹
  作者：Calvin L. Stevens、Stanley J. Dykstra

  DOI：10.1021/ja01646a039

  日期：1954.9
• Epoxyethers. XIV.^1,2 The Reaction with Grignard Reagents without Rearrangement
  作者：CALVIN L. STEVENS、WILLIAM HOLLAND

  DOI：10.1021/jo01100a001

  日期：1958.6
• Epoxyethers. II. The Epoxyether from α-Halocyclohexyl Phenyl Ketone¹
  作者：Calvin L. Stevens、Eugene Farkas

  DOI：10.1021/ja01123a012

  日期：1952.2
• Electrooxidative cyclization of N-acylhydrazones of aldehydes and ketones to .DELTA.3-1,3,4-oxadiazolines and 1,3,4-oxadiazoles
  作者：Toshiro Chiba、Mitsuhiro Okimoto

  DOI：10.1021/jo00031a014

  日期：1992.2

  The electrolytic oxidation of ketone N-acylhydrazones (1) in methanolic sodium acetate induced their intramolecular cyclization to the corresponding 2-methoxy-DELTA(3)-1,3,4-oxadiazolines 3. The thermal stability of a given oxadiazoline and what products were formed by its thermal decomposition was found to depend on the natures of the substituents at C-2. Thus, 2-methoxy-2-phenyloxadiazolines preferentially yielded oxiranes 5, whereas 2-alkyl-2-methoxyoxadiazolines preferentially gave enol ethers 6. 2,2-Dimethoxyoxadiazolines decomposed to the parent ketones and many unidentified products. The electrolytic oxidation of aldehyde N-acylhydrazones 2 gave 2,5-disubstituted 1,3,4-oxadiazoles 4. The oxidative cyclization of the N-benzoylhydrazones of aliphatic aldehydes gave especially high yields of the corresponding heterocycles.
• Synthesis and Antitremorine Activity of Amino Ketals
  作者：Howard L. Johnson、John E. Oneto

  DOI：10.1002/jps.2600540114

  日期：1965.1