3,5-di-(4-morpholyl)pyridine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,5-di-(4-morpholyl)pyridine
• 英文别名: 4-(5-Morpholin-4-ylpyridin-3-yl)morpholine
• 化学式: C₁₃H₁₉N₃O₂
• 分子量: 249.313
• InChiKey: VKMMCTCHVUPCET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  37.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,5-二溴吡啶 在 sodium amide 、 sodium t-butanolate 、 叔丁醇 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 3,5-di-(4-morpholyl)pyridine
  参考文献：
  名称：

  Vinter-Pasquier, Karine; Jamart-Gregoire, Brigitte; Caubere, Paul, Heterocycles, 1997, vol. 45, # 11, p. 2113 - 2129

  摘要：

  DOI：

文献信息

• Nickel-mediated amination chemistry. Part 1: Efficient aminations of (het)aryl 1,3-di and 1,3,5-trichlorides
  作者：Christophe Desmarets、Raphaël Schneider、Yves Fort

  DOI：10.1016/s0040-4039(00)00276-8

  日期：2000.4

  The first Ni-catalysed synthesis of di- and triamino substituted benzenes and diamino substituted pyridines from the corresponding aryl chlorides and amines is described.

  描述了由相应的芳基氯化物和胺进行的第一个Ni催化的二氨基和三氨基取代的苯和二氨基取代的吡啶的合成。
• Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
  申请人：AC Immune S.A.

  公开号：EP2377860A1

  公开（公告）日：2011-10-19

  The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.

  本发明涉及一组新化合物，可用于治疗与淀粉样蛋白相关的一组疾病和异常，如阿尔茨海默病，以及与淀粉样蛋白类似蛋白相关的疾病或病况。本发明的化合物还可用于治疗与视觉系统组织中的病理异常/变化相关的眼部疾病。本发明还涉及包含这些化合物的药物组合物，以及利用这些化合物制备用于治疗或预防与淀粉样和/或淀粉样类似蛋白相关的疾病或病况的药物的用途。还揭示了一种治疗或预防与淀粉样和/或淀粉样类似蛋白相关的疾病或病况的方法。
• Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins
  申请人：Kroth Heiko

  公开号：US20110256064A1

  公开（公告）日：2011-10-20

  The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.

  本发明涉及一组新化合物，可用于治疗与淀粉样蛋白相关的一组疾病和异常，如阿尔茨海默病，以及与淀粉样蛋白相关的疾病或病况。本发明的化合物还可用于治疗与视觉系统组织中的病理异常/变化相关的眼部疾病。本发明还涉及包含这些化合物的药物组合物，以及利用这些化合物制备用于治疗或预防与淀粉和/或淀粉样蛋白相关的疾病或病况的药物的用途。还公开了一种治疗或预防与淀粉和/或淀粉样蛋白相关的疾病或病况的方法。
• Nickel-catalysed synthesis of 3-chloroanilines and chloro aminopyridines via cross-coupling reactions of aryl and heteroaryl dichlorides with amines
  作者：Christophe Desmarets、Raphaël Schneider、Yves Fort

  DOI：10.1016/s0040-4039(00)01931-6

  日期：2001.1

  Selective monoamination of aryl and heteroaryl dichlorides has been carried out using a catalyst combination of Ni(0) associated to 2,2'-bipyridine. The synthesis of novel 3-chloroanilines and chloro aminopyridines in good to excellent yields is allowed using an excess of amine, 10 or 20 mol% catalyst and short reaction times. (C) 2000 Elsevier Science Ltd. All rights reserved.
• Vinter-Pasquier, Karine; Jamart-Gregoire, Brigitte; Caubere, Paul, Heterocycles, 1997, vol. 45, # 11, p. 2113 - 2129
  作者：Vinter-Pasquier, Karine、Jamart-Gregoire, Brigitte、Caubere, Paul

  DOI：——

  日期：——