alpha-picoline hydrobromide | 64563-66-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: alpha-picoline hydrobromide
• 英文别名: α-picolinium hydrobromide；α-picoline hydrobromide；α-picolinium bromide；2-methylpyridinium bromide；picoline hydrobomide；2-methyl-pyridine; hydrobromide；Picoline hydrobromide；2-methylpyridine;hydrobromide
• CAS: 64563-66-2
• 化学式: Br*C₆H₈N
• 分子量: 174.04
• InChiKey: BKFNEOXRGFXAML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.19
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  14.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-苯醌 、 alpha-picoline hydrobromide 生成 4-(2-methylpyridin-1-ium-1-yl)benzene-1,2-diol;bromide
  参考文献：
  名称：

  Jain, M. L.; Soni, R. P.; Saxena, J. P., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 8, p. 718 - 720

  摘要：

  DOI：
• 作为产物：
  描述：

  碳酸甲丙酯 、 2,3-二溴丙酸 以 乙腈 为溶剂， 反应 6.0h， 以50%的产率得到
  参考文献：
  名称：

  Features of the reaction of 2,3-dihalopropanoic acids with pyridines and nucleophilic addition to N-vinylpyridinium salts

  摘要：

  The example of vinylpyridinium salts to establish for the first time the possibility of nucleophilic addition to the vinyl group in quaternary ammonium salts, which provides evidence against the concept that such reactions involve d orbitals. The nucleophilic addition reaction was accomplished with triphenylphosphine and pyridine. In the latter case, the suggested reaction scheme was confirmed by the observation of the Wittig reaction under the action of carbon dioxide and the Stevens reaggangement involving the double bond of the pyridinium ring and migrating 2-phosphonioethyl group. Procedures for preparing the starting vinylpyridinium salts. Reaction schemes were siggested.

  DOI：

  10.1134/s107036320807030x
• 作为试剂：
  描述：

  1β-oxo-6α-(2-phenyl-acetylamino)-1λ⁴-penicillanic acid 在 碳酸甲丙酯 、 苯磺酰胺 、 alpha-picoline hydrobromide 作用下， 以 1,4-二氧六环 、 乙醚 、 二氯甲烷 为溶剂， 生成 (6R)-3t-bromo-3c-methyl-8-oxo-7c-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid benzyl ester
  参考文献：
  名称：

  Preparation of .DELTA.3-7.ALPHA.-phenylacetamidodesacetoxycephalosporanic acid.

  摘要：

  以N,O-双(三甲基硅基)乙酰胺(BSA)为硅烷化剂和脱水剂,α-甲基吡啶/α-甲基吡啶氢溴酸盐为反应剂,通过6-表苄青霉素-S-亚砜扩环制备Δ3-7α-苯基乙酰胺去乙酰氧基头孢烷酸。催化剂。在一些实验中，获得了副产物7α-苯基乙酰胺-3β-溴-3α-甲基头孢姆-4α-羧酸。去乙酰氧基头孢菌素系列中的 7-差向异构体也通过 7 β-(对硝基亚氨基)去乙酰氧基头孢菌酸苄酯和天然 6-苯基乙酰胺去乙酰氧基头孢菌酸甲酯的 S-亚砜的碱催化差向异构化来制备。在两个反应1中，5-二氮杂双环(4.3.0)壬-5-烯(DBN)均用作差向异构催化剂。

  DOI：

  10.7164/antibiotics.32.820

文献信息

• [EN] IMPROVED PROCESS FOR THE PREPARATION OF BIOLOGICALLY ACTIVE TETRAHYDROBENZTHIAZOLE DERIVATIVE<br/>[FR] PROCEDE AMELIORE DE PREPARATION D'UN DERIVE DE TETRAHYDROBENZOTHIAZOLE BIOLOGIQUEMENT ACTIF
  申请人：ALEMBIC LTD

  公开号：WO2006003677A1

  公开（公告）日：2006-01-12

  Improved process for the preparation of the intermediate compound of formula II for formation pramipezole of formula (I) as well as the biological active tetrahydrobenzothiazole compound of formula (I) and/or its pharmaceutically acceptable salts or solvates.

  改进的工艺用于制备式(I)的前体化合物的中间化合物II，以及式(I)的前体pramipezole的生物活性四氢苯并噻唑化合物和/或其药用可接受的盐或溶剂。
• [EN] PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉS DE PURINE EN TANT QU'INHIBITEURS DE CD73 POUR LE TRAITEMENT DU CANCER
  申请人：VITAE PHARMACEUTICALS INC

  公开号：WO2015164573A1

  公开（公告）日：2015-10-29

  Provided are novel compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are inhibitors of CD73 and are useful in the treatment of cancer.

  提供的是新颖化合物、其药学上可接受的盐以及其药物组合物，这些化合物是CD73的抑制剂，并可用于癌症治疗。
• Pyridinium Halides and Their Mixtures as Inhibitors of Steel Corrosion in Sulfuric Acid Solutions
  作者：R. I. Yurchenko、S. V. Ivashchenko、T. N. Pilipenko、I. S. Pogrebova

  DOI：10.1007/s11167-005-0329-5

  日期：2005.3

  Mixtures of 1-acylmethylpyridinium halides with equimolar amounts of pyridinium halides were prepared by the Ortoleva-King reaction. The inhibiting effect of various pyridinium halides and their mixtures on corrosion of steel in sulfuric acid solutions was studied.

  通过Ortoleva-King反应制备了1-酰甲基吡啶盐卤化物与等摩尔量的吡啶盐卤化物的混合物。研究了不同吡啶盐卤化物及其混合物对硫酸溶液中钢腐蚀的抑制作用。
• [EN] PROCESSES FOR PREPARING L-ALKYL-3-ALKYL-PYRIDINIUM BROMIDE AND USES THEREOF AS ADDITIVES IN ELECTROCHEMICAL CELLS<br/>[FR] PROCÉDÉS POUR LA PRÉPARATION DE BROMURE DE 1-ALKYL-3-ALKYLPYRIDINIUM ET SES UTILISATIONS COMME ADDITIF DANS DES CELLULES ÉLECTROCHIMIQUES
  申请人：BROMINE COMPOUNDS LTD

  公开号：WO2014122641A1

  公开（公告）日：2014-08-14

  The invention relates to the use of at least one l-alkyl-3- alkyl-pyridinium halide, in particular l-alkyl-3-methyl- pyridinium bromide, as an additive in bromine-generating electrochemical cells, such as zinc/bromine cells. Processes for preparing l-alkyl-3-methyl-pyridinium bromide and concentrated aqueous solutions comprising same for use as additives in the aforementioned cells, are also disclosed.

  本发明涉及在产生溴的电化学电池中使用至少一种l-烷基-3-烷基-吡啶盐，特别是l-烷基-3-甲基-溴化吡啶，作为添加剂。还公开了制备l-烷基-3-甲基-溴化吡啶和含有该物质的浓缩水溶液用作上述电池添加剂的方法。
• [EN] PROCESSES FOR PREPARING N-ETHYL-2-METHYLPYRIDINIUM BROMIDE AND N-ETHYL-3-METHYLPYRIDINIUM BROMIDE<br/>[FR] PROCÉDÉS DE PRÉPARATION DE BROMURE DE N-ÉTHYL-2-MÉTHYLPYRIDINIUM ET DE BROMURE DE N-ÉTHYL-3-MÉTHYLPYRIDINIUM
  申请人：BROMINE COMPOUNDS LTD

  公开号：WO2013042109A1

  公开（公告）日：2013-03-28

  The invention provides processes for preparing concentrated aqueous solutions of N-ethyl-2-methylpyridinium bromide and N- ethyl-3-methylpyridinium bromide, which solutions are useful as additives in the electrolyte of hydrogen/bromine electrochemical cells. Also provided are concentrated aqueous solutions of N-ethyl-2-methylpyridinium bromide, N-ethyl-3-methylpyridinium bromide and their mixtures.

  该发明提供了制备浓缩水溶液N-乙基-2-甲基吡啶溴化物和N-乙基-3-甲基吡啶溴化物的方法，这些溶液可作为氢/溴电化学电池电解质中的添加剂。同时提供了N-乙基-2-甲基吡啶溴化物、N-乙基-3-甲基吡啶溴化物及它们的混合物的浓缩水溶液。