2-phenyl-3-trifluoromethylbenzo[b]furan | 1240046-32-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-phenyl-3-trifluoromethylbenzo[b]furan
• 英文别名: 2-phenyl-3-(trifluoromethyl)benzofuran；2-Phenyl-3-(trifluoromethyl)-1-benzofuran；2-phenyl-3-(trifluoromethyl)-1-benzofuran
• CAS: 1240046-32-5
• 化学式: C₁₅H₉F₃O
• 分子量: 262.231
• InChiKey: NXMRPEPDOPYDND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-甲氧基-2-苯基乙炔-苯 在 potassium fluoride 、 copper(l) iodide 、 碘 、 (三氟甲基)三甲基硅烷 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 2-phenyl-3-trifluoromethylbenzo[b]furan
  参考文献：
  名称：

  通过串联碘代环化和2-炔基茴香醚的三氟甲基化一锅合成3-三氟甲基苯并呋喃

  摘要：

  已经开发了两步一锅串联碘环化和三氟甲基化。通过2-炔基茴香醚与元素碘和（三氟甲基）三甲基硅烷的串联反应，以中等至良好的产率制备了各种3-三氟甲基苯并呋喃。

  DOI：

  10.1016/j.tetlet.2014.01.061

文献信息

• Synthesis of 3-Trifluoromethylbenzo[<i>b</i>]furans from Phenols via Direct <i>Ortho</i> Functionalization by Extended Pummerer Reaction
  作者：Takayuki Kobatake、Daishi Fujino、Suguru Yoshida、Hideki Yorimitsu、Koichiro Oshima

  DOI：10.1021/ja1030134

  日期：2010.9.1

  diversity-oriented route to trifluoromethylbenzo[b]furans has been devised. A variety of phenols are directly converted to the corresponding 2-methylthio-3-trifluoromethylbenzo[b]furans by new triflic-anhydride-mediated extended Pummerer annulation reactions with trifluoromethylketene dithioacetal monoxide. The methylthio group of the products undergoes further transformations, which increase the diversity

  已经设计了一种简洁且面向多样性的三氟甲基苯并 [b] 呋喃路线。通过新的三氟甲磺酸酐介导的延长 Pummerer 环化反应与三氟甲基乙烯酮二硫代乙缩醛一氧化物，多种酚类直接转化为相应的 2-甲硫基-3-三氟甲基苯并 [b] 呋喃。产物的甲硫基经过进一步的转变，增加了可用三氟甲基苯并[b]呋喃的多样性。
• Synthesis of a Library of Fluorescent 2-Aryl-3-trifluoromethylnaphthofurans from Naphthols by Using a Sequential Pummerer-Annulation/Cross-Coupling Strategy and their Photophysical Properties
  作者：Yuuya Ookubo、Atsushi Wakamiya、Hideki Yorimitsu、Atsuhiro Osuka

  DOI：10.1002/chem.201201261

  日期：2012.10.1

  was the most efficient catalyst for the arylation step, which represents the first cross‐coupling of aryl sulfides by using an N‐heterocyclic‐carbene‐ligated palladium complex. This library consists of new π‐expanded molecules, all of which are fluorescent in the solid state as well as in solution. Their photophysical properties, such as absorption and emission, fluorescence quantum yields, and fluorescence

  从简单的萘酚中高效合成了2-芳基-3-三氟甲基萘呋喃文库。在该合成中，萘酚与3-（2,2,2-三氟亚乙基）-2-，4-二硫杂戊烷2-氧化物的Pummerer型环化后，将所得的2-甲硫基-3-三氟甲基萘呋喃与各种芳基锌试剂。钯配合物Pd-PEPPSI-IPr是芳基化步骤中最有效的催化剂，代表了使用N-杂环-卡宾连接的钯配合物实现的芳基硫醚的首次交叉偶联。该文库由新的π扩展分子组成，所有这些分子在固态和溶液中均发出荧光。对其吸收和发射，荧光量子产率和荧光寿命等光物理性质进行了彻底的研究。
• Synthesis of 3-Trifluoromethylbenzofurans via Palladium-Catalyzed Tandem Elimination/Annulation of β-Chloro-β-(trifluoromethyl)styrenes with 2-Halophenols
  作者：Lian-Hui Chen、Xing-Guo Zhang、Chong Wang、Chen-Liang Deng

  DOI：10.1055/s-0033-1338560

  日期：——

  A palladium-catalyzed tandem elimination and annulation reaction has been developed. In this way, a variety of 3-trifluoromethybenzofurans were prepared in moderate to good yields via tandem reaction of beta-chloro-beta-(trifluoromethyl)styrenes with 2-iodophenols and 2-bromophenols.
• One-pot synthesis of 3-trifluoromethylbenzofurans via tandem iodocyclization and trifluoromethylation of 2-alkynylanisoles
  作者：Wen-Ying Wang、Bo-Lun Hu、Chen-Liang Deng、Xing-Guo Zhang

  DOI：10.1016/j.tetlet.2014.01.061

  日期：2014.2

  A two-step, one-pot tandem iodocyclization and trifluoromethylation have been developed. A variety of 3-trifluoromethylbenzofurans were prepared in moderate to good yields via the tandem reaction of 2-alkynylanisoles with elemental iodine and (trifluoromethyl)trimethylsilane.

  已经开发了两步一锅串联碘环化和三氟甲基化。通过2-炔基茴香醚与元素碘和（三氟甲基）三甲基硅烷的串联反应，以中等至良好的产率制备了各种3-三氟甲基苯并呋喃。