2-(2-甲氧基苯甲酰基)苯甲酸 | 1151-04-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2-甲氧基苯甲酰基)苯甲酸
• 英文名称: 2-(2-methoxybenzoyl)benzoic acid
• 英文别名: 2-(2-methoxy-benzoyl)-benzoic acid；2-(2-Methoxy-benzoyl)-benzoesaeure；2'-Methoxy-benzophenon-carbonsaeure-(2)；2-<2-Methoxy-benzoyl>-benzoesaeure；2-(2-Methoxybenzoyl)-benzoesaeure；o,o'-Methoxybenzoyl-benzoesaeure
• CAS: 1151-04-8
• 化学式: C₁₅H₁₂O₄
• 分子量: 256.258
• InChiKey: FDRBINAKYXMDSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  2-(2-甲氧基苯甲酰基)苯甲酸 在 dipotassium peroxodisulfate 、 silver(I) acetate 作用下， 以 氘代乙腈 为溶剂， 反应 1.0h， 以51%的产率得到1-甲氧基芴-9-酮
  参考文献：
  名称：

  Decarboxylative C–H Arylation of Benzoic Acids under Radical Conditions

  摘要：

  A decarboxylative radical cyclization reaction has been developed for the synthesis of fluorenones. The reaction uses Ag(I)/K2S2O8 to oxidatively decarboxylate an aroylbenzoic acid to an aryl radical, which undergoes cyclization to afford fluorenone products in good yield.

  DOI：

  10.1021/ol3010694
• 作为产物：
  描述：

  4,4-二甲基-2-苯基-2-噁唑啉 在 盐酸 、 正丁基锂 作用下， 生成 2-(2-甲氧基苯甲酰基)苯甲酸
  参考文献：
  名称：

  o-Benzoylbenzoic acid synthesis by condensation of o-lithioaryloxazolines with acid chlorides. Preparation of a potential intermediate for anthracycline synthesis

  摘要：

  DOI：

  10.1021/jo00347a046

文献信息

• 2-Aroylbenzoyl Serine Proteases:  Photoreversible Inhibition or Photoaffinity Labeling?
  作者：Paul B. Jones、Ned A. Porter

  DOI：10.1021/ja9842518

  日期：1999.3.1

  an acyl thrombin was isolated that showed no lytic activity but which slowly regained activity in pH 7.4 buffer. Irradiation of this acyl enzyme with 366 nm light led to an enzyme that showed no gain of lytic activity over time. Incubation of chymotrypsin with 1a−3a and 4 led to acyl enzymes which showed no activity but which regained activity slowly. Irradiation of these inactive acyl enzymes with

  2-苯甲酰苯甲酸酯的苯酯被确定为丝氨酸蛋白酶糜蛋白酶和凝血酶的抑制剂。因此，对胍基苯基 2-苯甲酰苯甲酸酯 (1b) 抑制凝血酶，而相应的对硝基​​苯基酯 (1a) 抑制胰凝乳蛋白酶活性。制备了其他对硝基苯酯显示出作为胰凝乳蛋白酶抑制剂的活性，三种在苯甲酰基环上具有甲氧基取代：2-甲氧基 (2a)、2,5-二甲氧基 (3a) 和 2,4,5-三甲氧基苯甲酰基 (4 ）。与 1b 孵育后，分离出无裂解活性但在 pH 7.4 缓冲液中缓慢恢复活性的酰基凝血酶。用 366 nm 光照射这种酰基酶导致酶的裂解活性没有随时间增加。胰凝乳蛋白酶与 1a-3a 和 4 一起孵育导致酰基酶不显示活性但缓慢恢复活性。用 366 nm 光照射这些无活性的酰基酶导致酶活性迅速增加。酰基胰凝乳蛋白酶的形成...
• Isoindole derivatives
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US06608098B1

  公开（公告）日：2003-08-19

  This invention relates to compounds represented by the general formula [I]   wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3 and R4 are the same or different and represent hydrogen atoms, etc., X1 represents an oxygen atom, etc., X2 represents an oxygen atom, etc., Y represents an oxygen atom, etc., and Z represents a condensed aryl group, etc., or a pharmaceutically acceptable salt thereof, preparation processes thereof, and an agent for treating diabetes, a prophylactic agent for chronic complications of diabetes or a drug against obesity, containing, as an effective ingredient, the compound or the pharmaceutically acceptable salt thereof.

  这项发明涉及由一般式 [I] 表示的化合物，其中，R代表一个偶氮基团等，R1和R2相同或不同，代表氢原子等，R3和R4相同或不同，代表氢原子等，X1代表氧原子等，X2代表氧原子等，Y代表氧原子等，Z代表缩合芳基团等，或其药学上可接受的盐，其制备方法，以及用作治疗糖尿病的药剂，预防糖尿病慢性并发症的预防剂或用于对抗肥胖的药物，其有效成分为该化合物或其药学上可接受的盐。
• Novel isoindole derivatives
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US20040053923A1

  公开（公告）日：2004-03-18

  This invention relates to compounds represented by the general formula [I] 1 wherein, R represents an azido group, etc., R 1 and R 2 are the same or different and represent hydrogen atoms, etc., R 3 and R 4 are the same or different and represent hydrogen atoms, etc., X 1 represents an oxygen atom, etc., X 2 represents an oxygen atom, etc., Y represents an oxygen atom, etc., and Z represents a condensed aryl group, etc., or a pharmaceutically acceptable salt thereof, preparation processes thereof, and an agent for treating diabetes, a prophylactic agent for chronic complications of diabetes or a drug against obesity, containing, as an effective ingredient, the compound or the pharmaceutically acceptable salt thereof.

  本发明涉及由一般式[I]1表示的化合物，其中，R代表叠氮基等，R1和R2相同或不同，代表氢原子等，R3和R4相同或不同，代表氢原子等，X1代表氧原子等，X2代表氧原子等，Y代表氧原子等，Z代表紧缩芳基基团等，或其药学上可接受的盐，其制备方法以及作为治疗糖尿病的药物、预防糖尿病慢性并发症的预防剂或抗肥胖药物的有效成分，包含该化合物或其药学上可接受的盐。
• NOVEL ISOINDOLE DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1207161A1

  公开（公告）日：2002-05-22

  This invention relates to compounds represented by the general formula [I] wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3 and R4 are the same or different and represent hydrogen atoms, etc., X1 represents an oxygen atom, etc., X2 represents an oxygen atom, etc., Y represents an oxygen atom, etc., and Z represents a condensed aryl group, etc., or a pharmaceutically acceptable salt thereof, preparation processes thereof, and an agent for treating diabetes, a prophylactic agent for chronic complications of diabetes or a drug against obesity, containing, as an effective ingredient, the compound or the pharmaceutically acceptable salt thereof.

  本发明涉及通式[I]所代表的化合物 其中，R代表叠氮基等，R1和R2相同或不同且代表氢原子等，R3和R4相同或不同且代表氢原子等，X1代表氧原子等，X2代表氧原子等，Y代表氧原子等，Z代表缩合芳基等、或其药学上可接受的盐、其制备工艺，以及含有该化合物或其药学上可接受的盐作为有效成分的治疗糖尿病的药物、治疗糖尿病慢性并发症的预防药物或防治肥胖症的药物。
• o-Benzoylbenzoic acids by the reaction of lithium 2-lithiobenzoates with acid chlorides. A contribution to the chemistry of alizarin and podophyllotoxin
  作者：William E. Parham、Charles K. Bradsher、Kevin J. Edgar

  DOI：10.1021/jo00319a003

  日期：1981.3