3-(4'-Nitrophenyl)pentan | 38896-06-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4'-Nitrophenyl)pentan
• 英文别名: Benzene, 1-(1-ethylpropyl)-4-nitro-；1-nitro-4-pentan-3-ylbenzene
• CAS: 38896-06-9
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: GAZQCCDSGQTQLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4'-Nitrophenyl)pentan 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 以48%的产率得到1-(3-bromopentan-3-yl)-4-nitrobenzene
  参考文献：
  名称：

  Carbene-Catalyzed Reductive Coupling of Nitrobenzyl Bromide and Nitroalkene via the Single-Electron-Transfer (SET) Process and Formal 1,4-Addition

  摘要：

  A carbene-catalyzed reductive 1,4-addition of nitrobenzyl bromides to nitroalkenes is disclosed. The reaction proceeds via a carbene-enabled single-electron-transfer process that generates radicals as key intermediates. The present study expands the potentials of carbene catalysis and offers unusual transformations for common substrates in organic synthesis.

  DOI：

  10.1021/acs.orglett.6b03792
• 作为产物：
  描述：

  2-戊醇 在 三氯化铝 作用下， 生成 3-(4'-Nitrophenyl)pentan
  参考文献：
  名称：

  Revision of species of the “Oligia” semicana group (Lepidoptera: Noctuidae) with descriptions of a new genus and 12 new species

  摘要：

  AbstractThe name Neoligiagen.nov. is proposed for the "Oligia" semicana (Walker) species group in North America and 12 species, N. rubirena sp.nov., N. pagosa sp.nov., N. hardwicki sp.nov、N. inermis sp.nov.、N. invenusta sp.nov.、N. albirena sp.nov.、N. lancea sp.nov.、N. elephas sp.nov.、N. lillooet sp.nov.、N. surdirena sp.nov.、N. canadensis sp.nov.和 N. atlantica sp.nov.等 12 个种。Hadenella laevigata Smith 与 Hadena tonsa Grote 同源（同义恢复），Hadena hausta Grote 与 Miana semicana Walker 同源（同义恢复）。所有物种的成体以及已知的雄性和雌性生殖器均附有插图。

  DOI：

  10.4039/ent134157-2

文献信息

• [EN] FERROPTOSIS INHIBITORS–DIARYLAMINE PARA-ACETAMIDES<br/>[FR] INHIBITEURS DE FERROPTOSE-DIARYLAMINE PARA-ACÉTAMIDES
  申请人：SIRONAX LTD

  公开号：WO2021175200A1

  公开（公告）日：2021-09-10

  Provided are compounds that inhibit ferroptosis activity, or modulate or inhibit a disease associated with ferroptosis dysregulation, such as neuropathy, ischemia reperfusion injury, acute kidney failure and cancer, including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

  提供了抑制铁死亡活性的化合物，或调节或抑制与铁死亡失调相关的疾病，如神经病、缺血再灌注损伤、急性肾衰竭和癌症，包括相应的磺胺类化合物，以及其药用可接受的盐、水合物和立体异构体。这些化合物用于制备药物组合物，并且用于制备和使用方法，包括以有效剂量的化合物或组合物治疗需要的人，并检测人的健康或状况的改善。
• Transition-state polarization in cleavage of carbon-carbon bonds in radical anions
  作者：Przemyslaw Maslak、Javier N. Narvaez、Jozef Kula、David S. Malinski

  DOI：10.1021/jo00302a017

  日期：1990.7
• Zalesskaya,T.E.; Zhuravleva,L.E., Journal of general chemistry of the USSR, 1960, vol. 30, p. 2141 - 2143
  作者：Zalesskaya,T.E.、Zhuravleva,L.E.

  DOI：——

  日期：——
• High intensity ultrasound-assisted reduction of sterically demanding nitroaromatics
  作者：Georgios A. Heropoulos、Spyros Georgakopoulos、Barry R. Steele

  DOI：10.1016/j.tetlet.2005.02.038

  日期：2005.4

  Sterically demanding nitroaromatic compounds have been prepared and reduced to their corresponding amines with high intensity ultrasound using hydrazine in the presence of a Raney nickel catalyst. These reactions were dependent on catalyst quality, solvent and ultrasonic amplitude and, in comparison to their silent reactions, proceeded much faster and afforded higher yields. (c) 2005 Elsevier Ltd. All rights reserved.
• Maslak, Przemyslaw; Narvaez, Javier N., Angewandte Chemie, 1990, vol. 102, # 3, p. 302 - 304
  作者：Maslak, Przemyslaw、Narvaez, Javier N.

  DOI：——

  日期：——