4H-furo[3,2-b]pyrrole-5-carbohydrazide | 91206-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃吡咯
• 英文名称: 4H-furo[3,2-b]pyrrole-5-carbohydrazide
• CAS: 91206-29-0
• 化学式: C₇H₇N₃O₂
• mdl: MFCD08531054
• 分子量: 165.151
• InChiKey: QGJBRDAETPSJIU-UHFFFAOYSA-N

物化性质

• 密度：
  1.472±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  4H-furo[3,2-b]pyrrole-5-carbohydrazide 生成 furo[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazin-8(7H)-one
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  4H-呋喃并[3,2-b]吡咯-5-羧酸乙酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 20.0h， 以81%的产率得到4H-furo[3,2-b]pyrrole-5-carbohydrazide
  参考文献：
  名称：

  Krutosikova, Alzbeta; Kovac, Jaroslav; Dandarova Miloslava, Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 1, p. 65 - 70

  摘要：

  DOI：

文献信息

• Reactions of Substituted Furo[3,2-b]pyrrole-5-carbohydrazides Under Classical and Microwave Conditions
  作者：Renata Gašparová、Margita Lácová、Alžbeta Krutošíková

  DOI：10.1135/cccc20052101

  日期：——

  Substituted hydrazones 5 and 6 were synthesized by the reaction of the corresponding furo[3,2-b]pyrrole-5-carboxyhydrazides 1 with 6-substituted 4-oxochromene-3-carbaldehydes 2 and methyl 2-formylfuro[3,2-b]pyrrole-5-carboxylates 3 under microwave irradiation as well as by the classical method. The beneficial effect of the microwave irradiation on these reactions was a shortening of the reaction time and an increase in the yields. The reactions of 1 with 4-[(4-oxochromen-3-yl)methylidene]-2-phenyloxazol-5(4H)-one (4) were also studied. Compounds 7 or 8 were obtained, depending on the reaction temperature.

  通过微波辐射，将相应的呋喃[3,2-b]吡咯-5-羧酰肼 1 与6-取代的4-氧基色酮-3-甲醛 2 和甲基-2-甲酰基呋喃[3,2-b]吡咯-5-羧酸酯 3 反应，合成了取代肼酮 5 和 6。这些反应中微波辐射的有益效果是缩短了反应时间并提高了产率。此外，还研究了 1 与4-[(4-氧基色酮-3-基)甲亚甲基]-2-苯氧唑-5(4H)-酮 (4) 的反应。取决于反应温度，得到了化合物 7 或 8。
• Synthesis and Reactions of 8-Hydrazinofuro[2',3':4,5]pyrrolo-[1,2-d][1,2,4]triazines
  作者：Alžbeta Krutošíková、Slavomír Mastik、Miloslava Dandárová、Antonín Lyčka

  DOI：10.1135/cccc19971612

  日期：——

  5-Ethyl-8-hydrazinofuro[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine (4a) and its 2-methyl derivative 4b were prepared from 4H-furo[3,2-b]pyrrole-5-carbohydrazides 1a and 1b, respectively. Compounds 1a and 1b reacted with triethyl orthopropionate to give 2a and 2b which afforded with phosphorus(V) sulfide corresponding thiones 3a and 3b. The title compounds 4a and 4b were made by treatment of 3a and 3b with hydrazine hydrate. By reactions of triethyl orthoesters with the title compounds and similar derivatives furo[2'3':4,5]pyrrolo[1,2-d][1,2,4]triazolo[3,4-f][1,2,4]triazines 5a-5j were prepared. Reactions of compounds 4 with some aldehydes and isocyanates led to hydrazones 6a-6c and semicarbazones 7a and 7b, respectively.

  从4H-呋喃[3,2-b]吡咯-5-羟基脲化合物1a和1b分别合成了5-乙基-8-叠氮基呋喃[2',3':4,5]吡咯[1,2-d][1,2,4]三嗪（4a）及其2-甲基衍生物4b。化合物1a和1b与正丙酸三乙酯反应得到2a和2b，再与五价磷磺化合物反应形成相应的硫醚3a和3b。通过硫醚3a和3b与叠氮酸水合物反应制备了标题化合物4a和4b。通过正丙酸酯与标题化合物及类似衍生物的反应制备了呋喃[2'3':4,5]吡咯[1,2-d][1,2,4]三唑[3,4-f][1,2,4]三嗪5a-5j。化合物4与一些醛和异氰酸酯反应得到叠氮酮6a-6c和半胍酮7a和7b。
• Synthesis of furo[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine derivatives and their antibacterial activity
  作者：Ivana Zemanová、Renata Gašparová、Filip Kraic、Dáša Kružlicová、Tibor Maliar、Andrej Boháč、Gabriela Addová

  DOI：10.24820/ark.5550190.p009.788

  日期：——

  triethyl orthoesters or by acetylation of methyl 4H-furo[3,2-b]pyrrole-5-carboxylate 1 followed by thionation of 4-acetylfuro[3,2-b]pyrrole-5-carboxylate 3 and cyclisation of thione 4 with hydrazine. Triazine 5a afforded the corresponding thione 7 by reaction with P2S5. Upon reaction with alkylor acylhalogenides compounds 5 and 7 gave N(7)-substituted products 6 and 8, respectively. Finally, triazino-triazinone

  Furo[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazin-8(7H)-ones 5 是通过碳酰肼 2 与三乙酯原酸酯反应或通过乙酰化合成的4H-呋喃[3,2-b]吡咯-5-羧酸甲酯1的反应，然后是4-乙酰呋喃[3,2-b]吡咯-5-羧酸酯3的硫化和硫酮4与肼的环化。三嗪 5a 通过与 P2S5 反应得到相应的硫酮 7。与烷基或酰基卤化物反应后，化合物 5 和 7 分别得到 N(7)-取代的产物 6 和 8。最后，通过硫酮 8b 与肼的环化合成了三嗪基-三嗪酮衍生物 9。评价化合物5 9 的抗菌活性。
• 10.3998/ark.5550190.p009.788
  作者：Zemanová, Ivana、Gašparová, Renata、Kraic, Filip、Kružlicová, Dáša、Maliar, Tibor、Boháč, Andrej、Addová, Gabriela

  DOI：10.3998/ark.5550190.p009.788

  日期：——
• KRUTOSIKOVA, A.;KOVAC, J.;DANDAROVA, M., COLLECT. CZECHOSL. CHEM. COMMUN., 1984, 49, N 1, 65-70
  作者：KRUTOSIKOVA, A.、KOVAC, J.、DANDAROVA, M.

  DOI：——

  日期：——