2-溴-6-(四氢吡喃-2-氧基)萘 | 102938-66-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-溴-6-(四氢吡喃-2-氧基)萘
• 英文名称: 2-bromo-6-(tetrahydropyran-2-yloxy)naphthalene
• 英文别名: 2-(6-Bromo-2-naphthoxy)tetrahydropyran；2-(6-bromonaphthalen-2-yl)oxyoxane
• CAS: 102938-66-9
• 化学式: C₁₅H₁₅BrO₂
• 分子量: 307.187
• InChiKey: HQVYJZNFRLOZIB-UHFFFAOYSA-N

物化性质

• 沸点：
  426.1±35.0 °C(Predicted)
• 密度：
  1.413±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-溴-6-(四氢吡喃-2-氧基)萘 在 正丁基锂 、 酒石酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 34.0h， 生成 6-[1-(Dimethylamino)-3-hydroxy-2-methylpentan-3-yl]naphthalen-2-ol
  参考文献：
  名称：

  Preparation of novel analgesics via diastereoselective nucleophilic addition to 1-dimethylamino-2-methylpentan-3-one

  摘要：

  The diastereoselective synthesis of naphthyl amino alcohols via nucleophilic addition to raceMic 1-dimethylamino-2-methylpentan-3-one was studied. The use of the appropriate experimental conditions allowed the synthesis of both diastereoisomers. The relative configurations were established via NOESY experiments. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.12.060
• 作为产物：
  描述：

  6-溴-2-萘酚 、 2-(3,4-dimethoxybenzyloxy)tetrahydro-2H-pyran 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以54%的产率得到2-溴-6-(四氢吡喃-2-氧基)萘
  参考文献：
  名称：

  Utility of 3,4-Dimethoxybenzyl (DMPM) Glycosides. A New Glycosylation Triggered by 2,3-Dichloro-5,6-dicyano-p-benzoquinone (DDQ) Oxidation

  摘要：

  一种新的糖基化方法已被开发出来，该方法通过DMPM糖苷与DDQ形成电荷转移（CT）复合物，随后由氧化触发中间体碎裂进行。采用伯醇、仲醇和叔醇作为糖基受体，制备2-脱氧糖苷衍生物。

  DOI：

  10.1246/cl.1993.85

文献信息

• 重合性化合物及び光学異方体
  申请人：ＤＩＣ株式会社

  公开号：JP2017210409A

  公开（公告）日：2017-11-30

  【課題】重合性組成物に添加しフィルム状の重合物を作製した場合に、配向欠陥が少なく、高温状態に置かれた場合に変色が起こりにくい重合性組成物の提供。【解決手段】下式（I-6）で例示される化合物、該化合物を含有する重合性組成物、該組成物を重合させることにより得られる重合体及び該重合体を用いた光学異方体。【選択図】なし

  添加重合物形成薄膜时，提供一种配向缺陷较少且在高温下不易变色的重合物组成物。通过包含下式（I-6）所示化合物的重合物组成物，以及由该组成物聚合而成的聚合体和使用该聚合体制备的光学向列体来实现。【选择图】无
• POLYMERIZABLE COMPOUND, AND LIQUID CRYSTAL COMPOSITION PRODUCED USING SAME
  申请人：DIC CORPORATION

  公开号：US20160137921A1

  公开（公告）日：2016-05-19

  The polymerizable composition and the liquid crystal composition containing the polymerizable compound of the present invention have favorable storage stability as evaluated on the basis of the occurrence of precipitation, separation, or the like of crystals during storage. The present invention relates to a polymerizable compound, a liquid crystal composition which contains the compound, and further a liquid crystal display element which contains an optically anisotropic material which is a cured product of the liquid crystal composition, or a cured product which controls alignment of liquid crystal molecules. That is, the present invention relates to a polymerizable compound, and a liquid crystal composition containing the polymerizable compound which contains the polymerizable compound and a liquid crystal compound. The polymerizable compound is a compound represented by General Formula (I), and is useful for an optically anisotropic material, a retardation layer, an alignment film, or a polarizing layer.

  本发明的可聚合组合物和含有该可聚合化合物的液晶组合物在存储期间的晶体沉淀、分离等方面具有良好的稳定性。本发明涉及一种可聚合化合物、包含该化合物的液晶组合物以及进一步包含液晶组合物的光学各向异性材料的固化产物的液晶显示元件，或控制液晶分子取向的固化产物。也就是说，本发明涉及一种可聚合化合物和包含该可聚合化合物的液晶组合物，该可聚合化合物是由通式（I）表示的化合物，可用于光学各向异性材料、减速层、取向膜或偏振层。
• Design, synthesis, and SAR analysis of novel selective σ1 ligands
  作者：Simona Collina、Guya Loddo、Mariangela Urbano、Laura Linati、Athos Callegari、Francesco Ortuso、Stefano Alcaro、Christian Laggner、Thierry Langer、Orazio Prezzavento、Giuseppe Ronsisvalle、Ornella Azzolina

  DOI：10.1016/j.bmc.2006.10.048

  日期：2007.1

  A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to sigma(1) and sigma(2) receptors. Many compounds exhibited nanomolar affinity for sigma(1) subtype receptor with good selectivity over sigma(2). A molecular modeling study was conducted in order to rationalize the experimental data, and the structure-receptor affinities are discussed. (c) 2006 Elsevier Ltd. All rights reserved.
• Diastereoselective synthesis of chiral nonracemic naphthylaminoalcohols with analgesic activity
  作者：Ornella Azzolina、Simona Collina、Gloria Brusotti、Guya Loddo、Laura Linati、Enrica Lanza、Victor Ghislandi

  DOI：10.1016/j.tetasy.2004.03.036

  日期：2004.5

  The diastereoselective synthesis of chiral nonracemic naphthylaininoalcohols has been accomplished. The diastereoisomers, obtained in high enantiomeric excesses, were investigated by H-1 NMR and HPLC analyses. The configurational assignment was performed by NOESY H-1 NMR spectroscopy. Pharmacological evaluation of the analgesic activity by means of the hot plate test is described. (C) 2004 Elsevier Ltd. All rights reserved.
• [EN] COMPOUNDS<br/>[FR] COMPOSES
  申请人：ASTRAZENECA AB

  公开号：WO2004024060A2

  公开（公告）日：2004-03-25

  The invention provides compounds of formula, in which X, Y, R1, G1 and G2 have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.