tert-butyl (4-thioureidophenyl)carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (4-thioureidophenyl)carbamate
• 英文别名: tert-butyl N-[4-(carbamothioylamino)phenyl]carbamate
• 化学式: C₁₂H₁₇N₃O₂S
• 分子量: 267.352
• InChiKey: NPVLQFNCRINZRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl (4-thioureidophenyl)carbamate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 生成 4-(2-((4-aminophenyl)amino)thiazol-4-yl)benzene-1,2-diol
  参考文献：
  名称：

  Synthesis and in-vitro evaluation of 2-amino-4-arylthiazole as inhibitor of 3D polymerase against foot-and-mouth disease (FMD)

  摘要：

  Foot-and-mouth disease (FMD) is a highly contagious vesicular disease of livestock caused by a highly variable RNA virus, foot-and-mouth disease virus (FMDV). One of the targets to suppress expansion of and to control FMD is 3D polymerase (FMDV 3Dpol). In this study, 2-amino-4-arylthiazole derivatives were synthesized and evaluated for their inhibitory activity against FMDV 3Dpol. Among them, compound 20i exhibited the most potent functional inhibition (IC50 = 039 mu M) of FMDV 3D polymerase and compound 24a (EC50 = 13.09 mu M) showed more potent antiviral activity than ribavirin (EC50 = 1367 mu M) and T1105 (EC50 = 347 mu M) with IBRS-2 cells infected by the FMDV O/SKR/2010 strain. (C) 2015 Published by Elsevier Masson SAS.

  DOI：

  10.1016/j.ejmech.2015.08.020
• 作为产物：
  描述：

  特定基氨基甲酸脂酶 在 氨 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 0.5h， 生成 tert-butyl (4-thioureidophenyl)carbamate
  参考文献：
  名称：

  Synthesis and in-vitro evaluation of 2-amino-4-arylthiazole as inhibitor of 3D polymerase against foot-and-mouth disease (FMD)

  摘要：

  Foot-and-mouth disease (FMD) is a highly contagious vesicular disease of livestock caused by a highly variable RNA virus, foot-and-mouth disease virus (FMDV). One of the targets to suppress expansion of and to control FMD is 3D polymerase (FMDV 3Dpol). In this study, 2-amino-4-arylthiazole derivatives were synthesized and evaluated for their inhibitory activity against FMDV 3Dpol. Among them, compound 20i exhibited the most potent functional inhibition (IC50 = 039 mu M) of FMDV 3D polymerase and compound 24a (EC50 = 13.09 mu M) showed more potent antiviral activity than ribavirin (EC50 = 1367 mu M) and T1105 (EC50 = 347 mu M) with IBRS-2 cells infected by the FMDV O/SKR/2010 strain. (C) 2015 Published by Elsevier Masson SAS.

  DOI：

  10.1016/j.ejmech.2015.08.020

文献信息

• [EN] RECHARGEABLE BATTERY, FUNCTIONAL POLYMER, AND METHOD FOR SYNTHESIS THEREOF<br/>[FR] BATTERIE RECHARGEABLE, POLYMÈRE FONCTIONNEL, ET SON PROCÉDÉ DE SYNTHÈSE
  申请人：POLYTHIONE CO LTD

  公开号：WO2011152471A2

  公开（公告）日：2011-12-08

  　より安全な二次電池を提供する。より具体的には、過充電を防止するように構成された二次電池を提供する。　二次電池は、nドープ領域とpドープ領域を含む多電子反応可能な正極材料を用い、電解質(固体又は液体)の電解質塩濃度とそれらの絶対量が制御された電池である。この二次電池の正極では、充電時の低い電位( nドープ電位 )でまずリチウムイオンの脱離が起こり、次いで先ほどより高い電位( pドープ電位 )でアニオンの吸収が起こる。nドープ電位ではイオン電流のキャリアはリチウムイオンのみであるが、pドープ電位では正極側はアニオン電流、負極側はリチウムイオン電流が流れる。これにより、過充電前に、電解質濃度が減少して、内部抵抗が上昇し、過充電が回避される。
• Synthesis and in-vitro evaluation of 2-amino-4-arylthiazole as inhibitor of 3D polymerase against foot-and-mouth disease (FMD)
  作者：Kwi-wan Jeong、Jung-hun Lee、Sun-mi Park、Joo-Hyung Choi、Dae-Youn Jeong、Dong-Hwa Choi、Yeonju Nam、Jong-Hyeon Park、Kwang-Nyeong Lee、Su-Mi Kim、Jin-Mo Ku

  DOI：10.1016/j.ejmech.2015.08.020

  日期：2015.9

  Foot-and-mouth disease (FMD) is a highly contagious vesicular disease of livestock caused by a highly variable RNA virus, foot-and-mouth disease virus (FMDV). One of the targets to suppress expansion of and to control FMD is 3D polymerase (FMDV 3Dpol). In this study, 2-amino-4-arylthiazole derivatives were synthesized and evaluated for their inhibitory activity against FMDV 3Dpol. Among them, compound 20i exhibited the most potent functional inhibition (IC50 = 039 mu M) of FMDV 3D polymerase and compound 24a (EC50 = 13.09 mu M) showed more potent antiviral activity than ribavirin (EC50 = 1367 mu M) and T1105 (EC50 = 347 mu M) with IBRS-2 cells infected by the FMDV O/SKR/2010 strain. (C) 2015 Published by Elsevier Masson SAS.