4,5-dimethoxy-2-vinylbenzoic acid | 854872-66-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,5-dimethoxy-2-vinylbenzoic acid
• 英文别名: 4,5-Dimethoxy-2-vinyl-benzoesaeure；6-Vinylveratrinsaeure；2-Vinyl-veratrumsaeure；2-Ethenyl-4,5-dimethoxybenzoic acid；2-ethenyl-4,5-dimethoxybenzoic acid
• CAS: 854872-66-5
• 化学式: C₁₁H₁₂O₄
• 分子量: 208.214
• InChiKey: PGZNEIJOIMRFKR-UHFFFAOYSA-N

物化性质

• 熔点：
  184 °C
• 沸点：
  353.3±42.0 °C(predicted)
• 密度：
  1.183±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,5-dimethoxy-2-vinylbenzoic acid 在 草酰氯 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 2.0h， 生成 4,5-dimethoxy-N-methyl-2-vinylbenzamide
  参考文献：
  名称：

  Ring-Closing Metathesis Approach to 2H-2-Benzazepine-1,3-diones

  摘要：

  通过闭环偏合成反应，从不饱和前体 N-酰基邻乙烯基苯甲酰胺中高效地制备出了一系列不同取代度的 2H-2-苯并氮杂卓-1,3-二酮。母体化合物很容易从适当的邻乙烯基苯甲酸中获得。

  DOI：

  10.1055/s-0030-1258416
• 作为产物：
  描述：

  4,5-dimethoxy-2-vinylbenzaldehyde 在 氢氧化钾 、 乙醇 、 silver nitrate 作用下， 生成 4,5-dimethoxy-2-vinylbenzoic acid
  参考文献：
  名称：

  2-Acylstyrenes from 3,4-Dihydroisoquinolines¹

  摘要：

  DOI：

  10.1021/ja01589a063

文献信息

• Palladium-catalyzed <i>ortho</i>-halogen-induced deoxygenative approach of alkyl aryl ketones to 2-vinylbenzoic acids
  作者：Shankar Ram、Ajay Kumar Sharma、Arvind Singh Chauhan、Pralay Das

  DOI：10.1039/d0cc02941f

  日期：——

  polymer chemistry and are key precursors for the synthesis of important bioactive molecules. Herein, an ortho-halogen-induced deoxygenative approach for the generation of 2-vinylbenzoic acids from alkyl aryl ketones by palladium catalysis is discovered and explored. This approach requires no base or stoichiometric additives and can be carried out through a simple one-step process. Furthermore, the present

  2-乙烯基苯甲酸在聚合物化学领域具有广泛的应用，并且是合成重要生物活性分子的关键前体。在这里，一个邻-卤素诱导的脱氧方法，通过钯催化从烷基芳基酮生成2-乙烯基苯甲酸。该方法不需要碱或化学计量的添加剂，可以通过简单的一步过程进行。此外，本反应可扩展至一克规模。市售的碳载钯（5 wt％）用作多相催化剂，显示出极好的可回收性（<5倍），而催化活性没有明显损失。令人满意地，在我们的优化条件下，α烷基取代的2-碘苯乙酮表现出良好的非对映选择性，并且以良好的至优异的产率获得了主要的（E）-2-乙烯基苯甲酸。
• Survey of Staphylococcal Enterotoxin Genes, Exfoliative Toxin Genes, and Toxic Shock Syndrome Toxin 1 Gene in Non-Staphylococcus aureus Species
  作者：K. Becker、G. Haverkämper、C. von Eiff、R. Roth、G. Peters

  DOI：10.1007/pl00011281

  日期：2001.6

  The aim of this study was to analyze the presence of staphylococcal exotoxin genes in staphylococci other than Staphylococcus aureus. Whereas for Staphylococcus aureus a large spectrum of different exotoxins responsible for toxin-mediated diseases has been described, only few and conflicting data are available regarding toxin production in all other staphylococcal species. A collection of clinical non-Staphylococcus aureus staphylococcal isolates were systematically screened for the presence of genes for toxic shock syndrome toxin 1, exfoliative toxins, and classical enterotoxins by using multiplex polymerase chain reaction enzyme immunoassays. In a total of 461 isolates of 18 different (sub)species derived from clinical specimens, no toxin gene sequences were amplified. The results indicate that the occurrence of toxin genes involved in staphylococcal toxin-mediated diseases is at least very rare in human-derived isolates of non-Staphylococcus aureus species.
• Suzuki–Miyaura cross-coupling and ring-closing metathesis: a strategic combination to the synthesis of indeno[1,2-c]isoquinolin-5,11-diones
  作者：Stéphane Lebrun、Axel Couture、Eric Deniau、Pierre Grandclaudon

  DOI：10.1016/j.tetlet.2011.01.113

  日期：2011.3

  A variety of diversely substituted isoindeno[1,2-c]isoquinolin-5,11-diones has been readily assembled through a sequence involving a Suzuki-Miyaura cross-coupling reaction with enol phosphates combined with a ring-closing metathesis (RCM) reaction. Intramolecular carbocationic annulation reaction and ultimate oxidation of a latent hydroxyl functionality completed the synthesis of the target titled compounds. (c) 2011 Elsevier Ltd. All rights reserved.
• Kondo; Kondo, Chemical Abstracts, 1928, vol. 22, p. 3414
  作者：Kondo、Kondo

  DOI：——

  日期：——