bis(3,4-dimethoxybenzyl) sulfide | 110055-34-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(3,4-dimethoxybenzyl) sulfide
• 英文别名: diveratryl sulfide；Diveratryl-sulfid；4-[(3,4-Dimethoxyphenyl)methylsulfanylmethyl]-1,2-dimethoxybenzene
• CAS: 110055-34-0
• 化学式: C₁₈H₂₂O₄S
• 分子量: 334.436
• InChiKey: WNUNWRLEWYQBNK-UHFFFAOYSA-N

物化性质

• 熔点：
  90-91 °C
• 沸点：
  447.5±40.0 °C(Predicted)
• 密度：
  1.141±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  62.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  bis(3,4-dimethoxybenzyl) sulfide 在 双氧水 作用下， 生成 bis(3,4-dimethoxybenzyl) sulfoxide
  参考文献：
  名称：

  p-Hydroxy-Benzyl Ethers As Lignin Models. II

  摘要：

  DOI：

  10.1246/bcsj.27.53
• 作为产物：
  描述：

  3,4-二甲氧基苄氯 在 sodium sulfide 作用下， 生成 bis(3,4-dimethoxybenzyl) sulfide
  参考文献：
  名称：

  Gierer; Alfredsson, Chemische Berichte, 1957, vol. 90, p. 1240,1248

  摘要：

  DOI：

文献信息

• Furan derivatives, method of synthesis and uses thereof
  申请人：Neuropharma S.A.

  公开号：EP1939191A1

  公开（公告）日：2008-07-02

  The present invention relates to furan derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.

  本发明涉及式(I)的呋喃衍生物，其合成方法及用途。具体来说，所披露的化合物已被证明是糖原合成酶激酶3β（GSK-3β）的抑制剂，GSK-3β已知参与不同疾病和病况，如阿尔茨海默病或非胰岛素依赖型糖尿病。本发明还涉及包含这些化合物的药物组合物。此外，本发明旨在将这些化合物用于制造治疗和/或预防GSK-3介导的疾病或病况的药物。
• Stable S-nitrosothiols, method of synthesis and use
  申请人：LACER, S.A.

  公开号：EP1939179A1

  公开（公告）日：2008-07-02

  The present invention relates to stable S-nitrosothiols derivatives of formula (I) having vasodilating effect and which inhibit the aggregation of the platelets and which therefore are useful for the preparation of medicaments for treatment of NO related diseases. The invention also relates to a process for the synthesis of the compounds of formula (I) and to intermediate compounds thereof.

  本发明涉及具有扩血管作用的稳定S-亚硝基硫醇衍生物的公式(I)，这些衍生物抑制血小板聚集，因此可用于制备治疗与NO相关疾病的药物。该发明还涉及公式(I)化合物的合成过程以及其中间体化合物。
• (4-mercapto-piperidin-4-yl)-aminoacetic acid derivatives, pharmaceutical compositions and uses thereof
  申请人：LACER, S.A.

  公开号：EP2601940A1

  公开（公告）日：2013-06-12

  The invention provides (4-mercapto-piperidin-4-yl)-aminoacetic acid derivatives of formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, for use as a medicament, preferably for use in the treatment and/or prophylaxis of gastrointestinal ulcer, as well as pharmaceutical compositions comprising said thiol derivatives, or a pharmaceutically acceptable salt or stereoisomer thereof, and one or more pharmaceutically acceptable carriers.

  该发明提供了式(I)的(4-巯基-哌啶-4-基)-氨基乙酸衍生物，或其药用可接受的盐或立体异构体，用作药物，优选用于治疗和/或预防胃肠溃疡，以及包含所述硫醇衍生物的药物组合物，或其药用可接受的盐或立体异构体，和一个或多个药用可接受的载体。
• [EN] (4-MERCAPTO-PIPERIDIN-4-YL)-AMINOACETIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF<br/>[FR] DÉRIVÉS D'ACIDE (4-MERCAPTO-PIPÉRIDIN-4-YL)-AMINOACÉTIQUE, COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS DE CEUX-CI
  申请人：LACER SA

  公开号：WO2013083541A1

  公开（公告）日：2013-06-13

  The invention provides (4-mercapto-piperidin-4-yl)-aminoacetic acid derivatives of formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, for use as a medicament, preferably for use in the treatment and/or prophylaxis of gastrointestinal ulcer, as well as pharmaceutical compositions comprising said thiol derivatives, or a pharmaceutically acceptable salt or stereoisomer thereof, and one or more pharmaceutically acceptable carriers.

  该发明提供了公式(I)的(4-巯基-哌啶-4-基)-氨基乙酸衍生物，或其药用盐或立体异构体，用作药物，优选用于治疗和/或预防胃肠溃疡，以及包含所述硫醇衍生物或其药用盐或立体异构体以及一个或多个药用载体的药物组合物。
• <i>p</i>-Hydroxy-Benzyl Ethers As Lignin Models. II
  作者：Hiroshi Mikawa

  DOI：10.1246/bcsj.27.53

  日期：1954.1