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2,6-di(4-isopropylphenyl)pyridine | 203445-80-1

中文名称
——
中文别名
——
英文名称
2,6-di(4-isopropylphenyl)pyridine
英文别名
2,6-bis(4-propan-2-ylphenyl)pyridine
2,6-di(4-isopropylphenyl)pyridine化学式
CAS
203445-80-1
化学式
C23H25N
mdl
——
分子量
315.458
InChiKey
UESJTJVNDVGDBV-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    7.1
  • 重原子数:
    24
  • 可旋转键数:
    4
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.26
  • 拓扑面积:
    12.9
  • 氢给体数:
    0
  • 氢受体数:
    1

反应信息

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文献信息

  • Pharmaceutically active compounds and methods of use
    申请人:Durant J. Graham
    公开号:US20050209222A1
    公开(公告)日:2005-09-22
    The present invention relates to certain imine-substituted heterocyclic compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.
    本发明涉及某些亚胺取代的杂环化合物,以及利用或包含一种或多种此类化合物的治疗方法和制药组合物。本发明的化合物特别适用于治疗或预防神经损伤和神经退行性疾病。
  • PROCESS FOR PRODUCTION OF DISULFONIC ACID COMPOUND, ASYMMETRIC MANNICH CATALYST, PROCESS FOR PRODUCTION OF -AMINOCARBONYL DERIVATIVE, AND NOVEL DISULFONATE SALT
    申请人:National University Corporation Nagoya University
    公开号:EP2208722A1
    公开(公告)日:2010-07-21
    Hexamethylphosphoramide (HMPA) was added to a reaction vessel containing (R)-1,1'-binaphthyl-2,2'-dithiol and potassium hydroxide. The vessel was purged with oxygen and stirred at 80°C for 5 days under 7 atmospheres of oxygen. After being cooled to room temperature, the reaction product was purified to yield potassium (R)-1,1'-binaphthyl-2,2'-disulfonate. The (R)-1,1'-binaphthyl-2,2'-disulfonic acid obtained from the disulfonate and 2,6-diphenylpyridine were stirred in acetonitrile, and then the solvent was evaporated under reduced pressure. Subsequently, magnesium sulfate and distilled CH2Cl2 were added to the reaction product, and the mixture was stirred at room temperature for 30 minutes. The resulting solution was cooled to 0°C. Benzaldehyde imine whose nitrogen is protected with Cbz and subsequently acetyl acetone were dropped into the solution over a period of 1 hour. The resulting mixture was further stirred at 0°C for 30 minutes. A corresponding β-aminocarbonyl derivative was thus produced with an yield of 91% and an enantiomeric excess of 90% ee.
    在装有 (R)-1,1'-联萘-2,2'-二硫醇和氢氧化钾的反应容器中加入六甲基磷酰胺(HMPA)。在 7 个大气压的氧气条件下,用氧气吹扫该容器并在 80°C 下搅拌 5 天。冷却至室温后,纯化反应产物,得到(R)-1,1'-联萘-2,2'-二磺酸钾。将从二磺酸盐中得到的 (R)-1,1'-联萘-2,2'-二磺酸和 2,6-二苯基吡啶在乙腈中搅拌,然后减压蒸发溶剂。随后,向反应产物中加入硫酸镁和蒸馏过的 CH2Cl2,并在室温下搅拌混合物 30 分钟。所得溶液冷却至 0°C。在 1 小时内向溶液中滴入氮被 Cbz 保护的苯甲醛亚胺,随后滴入乙酰丙酮。所得混合物在 0°C 下继续搅拌 30 分钟。由此制得相应的 β-氨基羰基衍生物,收率为 91%,对映体过量率为 90%ee。
  • EP0959887A4
    申请人:——
    公开号:EP0959887A4
    公开(公告)日:2003-01-08
  • PROCESS FOR MANUFACTURING DISULFONIC ACID COMPOUND, ASYMMETRIC MANNICH CATALST, PROCESS FOR MANUFACTURING BETA-AMINOCARBONYL DERIVATIVE, AND NOVEL DISULFONATE
    申请人:Ishihara Kazuaki
    公开号:US20100249431A1
    公开(公告)日:2010-09-30
    Hexamethylphosphoramide (HMPA) was added to a reaction vessel containing (R)-1,1′-binaphthyl-2,2′-dithiol and potassium hydroxide. The vessel was purged with oxygen and stirred at 80° C. for 5 days under 7 atmospheres of oxygen. After being cooled to room temperature, the reaction product was purified to yield potassium (R)-1,1′-binaphthyl-2,2′-disulfonate. The (R)-1,1′-binaphthyl-2,2′-disulfonic acid obtained from the disulfonate and 2,6-diphenylpyridine were stirred in acetonitrile, and then the solvent was evaporated under reduced pressure. Subsequently, magnesium sulfate and distilled CH 2 Cl 2 were added to the reaction product, and the mixture was stirred at room temperature for 30 minutes. The resulting solution was cooled to 0° C. Benzaldehyde imine whose nitrogen is protected with Cbz and subsequently acetyl acetone were dropped into the solution over a period of 1 hour. The resulting mixture was further stirred at 0° C. for 30 minutes. A corresponding β-aminocarbonyl derivative was thus produced with an yield of 91% and an enantiomeric excess of 90% ee.
  • US6756389B2
    申请人:——
    公开号:US6756389B2
    公开(公告)日:2004-06-29
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