3-methoxy-3-methyl-2-butanone oxime | 15403-10-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-methoxy-3-methyl-2-butanone oxime
• 英文别名: 3-methoxy-3-methyl-butan-2-one oxime；3-Methoxy-3-methyl-butan-2-on-oxim；Methyl-methoxyisopropyl-ketoxim；N-(3-methoxy-3-methylbutan-2-ylidene)hydroxylamine
• CAS: 15403-10-8
• 化学式: C₆H₁₃NO₂
• 分子量: 131.175
• InChiKey: RKTUCGMLBXBRGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-methoxy-3-methyl-2-butanone oxime 在 盐酸 作用下， 生成 3-羟基-3-甲基-2-丁酮
  参考文献：
  名称：

  Schmidt,J.; Austin, Chemische Berichte, 1902, vol. 35, p. 3725

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-2-丁烯 在 乙醚 、 亚硝酰氯 、 calcium carbonate 作用下， 生成 3-methoxy-3-methyl-2-butanone oxime
  参考文献：
  名称：

  Danilow; Ogloblin, Zhurnal Obshchei Khimii, 1952, vol. 22, p. 2113,2118;engl.Ausg.S.2167,2171

  摘要：

  DOI：

文献信息

• Schmidt,J.; Leipprand, Chemische Berichte, 1904, vol. 37, p. 540
  作者：Schmidt,J.、Leipprand

  DOI：——

  日期：——
• Schmidt,J., Chemische Berichte, 1902, vol. 35, p. 3732
  作者：Schmidt,J.

  DOI：——

  日期：——
• An efficient synthesis of some 6-substituted 4,8-diaza-3,3,9,9- tetramethylundeca-2,10-dione dioximes (propylene amine oximes, PnAOs): Ligands for 99mTc complexes used in structure distribution relationship (SDR) studies
  作者：Palaniappa Nanjappan、Natarajan Raju、Kondareddiar Ramalingam、David P. Nowotnik

  DOI：10.1016/s0040-4020(01)85336-9

  日期：1994.1

  Technetium complexes of the ligand PnAO [4,8-diaza-3,3,9,9-fetramethylundeca-2,10-dione dioximes (3)] are of interest as commercial radiopharmaceuticals. In general, PnAOs are synthesized by alkylation of a propylenediamine derivative with 3-chloro-3-methyl-2-nitrosobutane (2). This alkylation reaction proved to be low yielding. With modestly bulky substituents at the 2-position of 1,3-diaminopropane, little or none of the required PnAO was obtained. As a result, an alternative approach of the synthesis of PnAO was developed. This method involved the alkylation of the propylenediamine with 3-bromo-3-methylbutan-2-one (18) followed by oximation of the resulting diamine-diketone (19). By this method, PnAOs were prepared in goad yield, even with bulky C-2 substituents. Fourteen PnAO derivatives were prepared by this method. We also describe the syntheses of several new propylenediamine derivatives.
• The Reactions of Nitric Oxide with Tri- and Tetramethylethylene. The β-Nitroolefin and Nitrosite Rearrangements
  作者：Charles A. Burkhard、John F. Brown

  DOI：10.1021/jo01031a030

  日期：1964.8
• Efe, Ergun G.; Schlemper, O. E., Polyhedron, 1991, vol. 10, p. 1611 - 1616
  作者：Efe, Ergun G.、Schlemper, O. E.

  DOI：——

  日期：——