(E)-1-(2,4-dichlorophenyl)-2-diethoxyphosphoryl-3-(dimethylamino)prop-2-en-1-one | 1350374-67-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-(2,4-dichlorophenyl)-2-diethoxyphosphoryl-3-(dimethylamino)prop-2-en-1-one
• CAS: 1350374-67-2
• 化学式: C₁₅H₂₀Cl₂NO₄P
• 分子量: 380.208
• InChiKey: MUAVIGCZNAFDBH-GXDHUFHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (E)-1-(2,4-dichlorophenyl)-2-diethoxyphosphoryl-3-(dimethylamino)prop-2-en-1-one 、 甲胺 以 乙醚 、 乙醇 为溶剂， 反应 1.0h， 生成 、 diethyl (E)-(3-(2,4-dichlorophenyl)-1-(methylamino)-3-oxoprop-1-en-2-yl)phosphonate
  参考文献：
  名称：

  Efficient syntheses of 3-phosphorylquinolin-4-ones and 3-phosphoryl-1,8-naphthyridin-4-ones

  摘要：

  A series of 3-diethoxyphosphorylquinolin-4-ones and 3-diethoxyphosphoryl-1,8-naphthyridin-4-ones containing various substituents at N-1 and C-7 was synthesized in a four-step reaction sequence starting from readily available ethyl 2-chlorobenzoates or ethyl 2-chloronicotinates and diethyl methylphosphonate. Selected quinolinone and naphthyridinone products were transformed into free mono and diacids. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.144
• 作为产物：
  描述：

  甲基膦酸二乙酯 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 20.5h， 生成 (E)-1-(2,4-dichlorophenyl)-2-diethoxyphosphoryl-3-(dimethylamino)prop-2-en-1-one
  参考文献：
  名称：

  Efficient syntheses of 3-phosphorylquinolin-4-ones and 3-phosphoryl-1,8-naphthyridin-4-ones

  摘要：

  A series of 3-diethoxyphosphorylquinolin-4-ones and 3-diethoxyphosphoryl-1,8-naphthyridin-4-ones containing various substituents at N-1 and C-7 was synthesized in a four-step reaction sequence starting from readily available ethyl 2-chlorobenzoates or ethyl 2-chloronicotinates and diethyl methylphosphonate. Selected quinolinone and naphthyridinone products were transformed into free mono and diacids. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.144

文献信息

• Efficient syntheses of 3-phosphorylquinolin-4-ones and 3-phosphoryl-1,8-naphthyridin-4-ones
  作者：Jacek Kędzia、Jakub Modranka、Tomasz Janecki

  DOI：10.1016/j.tetlet.2011.09.144

  日期：2011.12

  A series of 3-diethoxyphosphorylquinolin-4-ones and 3-diethoxyphosphoryl-1,8-naphthyridin-4-ones containing various substituents at N-1 and C-7 was synthesized in a four-step reaction sequence starting from readily available ethyl 2-chlorobenzoates or ethyl 2-chloronicotinates and diethyl methylphosphonate. Selected quinolinone and naphthyridinone products were transformed into free mono and diacids. (C) 2011 Elsevier Ltd. All rights reserved.