1-(imidazo[1,2-a]pyridin-3-yl)propan-1-one | 790204-05-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 1-(imidazo[1,2-a]pyridin-3-yl)propan-1-one
• 英文别名: 1-(1H-imidazo[1,2-a]pyridin-3-yl)propan-1-one；1-Imidazo[1,2-a]pyridin-3-ylpropan-1-one
• CAS: 790204-05-6
• 化学式: C₁₀H₁₀N₂O
• 分子量: 174.202
• InChiKey: KNCRUVAVBAKAED-UHFFFAOYSA-N

物化性质

• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  34.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(imidazo[1,2-a]pyridin-3-yl)propan-1-one 在 溴 、 三乙胺 、 三氟乙酸 作用下， 以 乙醚 、 二氯甲烷 、 乙腈 为溶剂， 反应 17.5h， 生成 6-bromo-3-(imidazo[1,2-a]pyridin-3-yl)-2-methylquinoxaline
  参考文献：
  名称：

  Reddy, B. Jayachandra; Reddy, M.C. Somasekhara, Journal of the Chilean Chemical Society, 2010, vol. 55, # 4, p. 483 - 485

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(pyridin-2-ylamino)pentan-3-one 在 双氧水 、 碘 作用下， 以 neat (no solvent) 为溶剂， 以56%的产率得到1-(imidazo[1,2-a]pyridin-3-yl)propan-1-one
  参考文献：
  名称：

  I2 催化的 C(sp3)-H 键的分子内氧化胺化：在纯净条件下有效获得 3-酰基咪唑并[1,2-a]吡啶†

  摘要：

  已经开发了一种通过羰基化合物的分子内氧化 α-胺化合成 3-酰基咪唑并[1,2- a ]吡啶的有效且“绿色”的方案。以I 2为催化剂，H 2 O 2为氧化剂，反应在纯净条件下顺利进行，底物范围广。几个复杂的含氮稠环结构方便，传统方法不易获得。

  DOI：

  10.1039/c8ra10118c

文献信息

• IMIDAZOPYRIDINYL THIAZOLYL HISTONE DEACETYLASE INHIBITORS
  申请人：Melvin, JR. Lawrence S.

  公开号：US20090005374A1

  公开（公告）日：2009-01-01

  A compound of general Formula (I) having histone deacetylase (HDAC) and/or CDK inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.

  具有组蛋白去乙酰化酶（HDAC）和/或CDK抑制活性的一般式（I）化合物，包括该化合物的药物组合物，以及使用该化合物治疗疾病的方法。
• Ultrasonicated Synthesis of<i>N</i>-Benzyl-2,3-substituted Morpholines, via the Mitsunobu Diol Cyclisation
  作者：B. Jayachandra Reddy、M. C. Somasekhara Reddy

  DOI：10.1155/2010/931015

  日期：——

  A facile five step synthesis ofN-benzyl-2,3-substituted morpholines (i-iii) was performed. The key steps were microwave assisted Friedel-crafts acylation and diol cyclization carried out via an ultra sonication of Mitsunobu reaction using DEAD (diethylazodicarboxylate), TPP in THF for 1 h. The morpholine products were generated as diasteriomers (iiandiii) which has been separated by the column chromatography to good yield. The structure of compounds (i-iii) has been characterized by the spectral and chemical studies.

  进行了一种简单的五步合成N-苄基-2,3-取代吗啡啶（i-iii）。关键步骤是利用微波辅助的Friedel-crafts酰化和二醇环化，通过超声Mitsunobu反应（使用DEAD（二乙基叠氮二甲酸酯），TPP在THF中反应1小时）。吗啡啶产物生成为二对映异构体（ii和iii），通过色谱柱分离获得良好收率。这些化合物（i-iii）的结构已通过光谱和化学研究进行了表征。
• 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives
  申请人：Love John Christopher

  公开号：US20070203189A1

  公开（公告）日：2007-08-30

  This invention concerns the use of a compound of formula (I′) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; C 1-6 alkyl; C 1-6 alkylcarbonyl; C 1-6 alkyloxycarbonyl; aminocarbonyl; C 1-6 alkyl substituted with hydroxy, carboxyl, cyano, amino, amino substituted with piperidinyl, amino substituted with C 1-4 alkyl substituted piperidinyl, mono- or di(C 1-6 alkyl)amino, aminocarbonyl, mono- or di(C 1-6 alkyl)aminocarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyloxy, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl; polyhaloC 1-4 alkyl; cyano; amino; mono- or di(C 1-6 alkyl)aminocarbonyl; C 1-6 alkyloxycarbonyl; C 1-6 alkylcarbonyloxy; aminoS(═O) 2 —; mono- or di(C 1-6 alkyl)aminoS(═O) 2 ; —C(═N—R x )NR y R z ; Q is optionally substituted C 3-6 cycloalkyl, phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl, or Q is a radical of formula L is optionally substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of inflammatory and/or auto-immune diseases mediated through TNF-α and/or IL-12.
• Antibacterial Compounds
  申请人：Janssen Sciences Ireland UC

  公开号：US20180155341A1

  公开（公告）日：2018-06-07

  The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
• HETEROCYCLIC COMPOUNDS AS ANTIBACTERIALS
  申请人：Janssen Sciences Ireland Unlimited Company

  公开号：US20190134046A1

  公开（公告）日：2019-05-09

  The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.