7-(4-pyridyl)-3-methyl-[1,2,3]triazolo[1,5-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 7-(4-pyridyl)-3-methyl-[1,2,3]triazolo[1,5-a]pyridine
• 英文别名: 3-Methyl-7-pyridin-4-yltriazolo[1,5-a]pyridine；3-methyl-7-pyridin-4-yltriazolo[1,5-a]pyridine
• 化学式: C₁₂H₁₀N₄
• 分子量: 210.238
• InChiKey: CSVFLHBRHUWMFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-甲基[1,2,3]噻唑并[1,5-a]吡啶 在 barium dihydroxide 、 四(三苯基膦)钯 、 正丁基锂 、 magnesium sulfate 作用下， 以 正己烷 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 100.0h， 生成 7-(4-pyridyl)-3-methyl-[1,2,3]triazolo[1,5-a]pyridine
  参考文献：
  名称：

  Synthesis of novel triazolopyridylboronic acids and esters. Study of potential application to Suzuki-type reactions

  摘要：

  This paper describes a general method for the synthesis of novel [1,2,3]triazolo[1,5-a]pyridylboronic acids and esters, and the first results on Suzuki cross-coupling reactions with these new compounds and [1,2,3]triazolo[5,1-a]isoquinolylboronic acid, reacting with a variety of aryl halides as a route to 7-aryltriazolopyridines and 5-aryltriazoloisoquinolines. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.03.083

文献信息

• Synthesis of novel triazolopyridylboronic acids and esters. Study of potential application to Suzuki-type reactions
  作者：Belén Abarca、Rafael Ballesteros、Fernando Blanco、Alexandre Bouillon、Valérie Collot、José-Reynaldo Domı́nguez、Jean-Charles Lancelot、Sylvain Rault

  DOI：10.1016/j.tet.2004.03.083

  日期：2004.5

  This paper describes a general method for the synthesis of novel [1,2,3]triazolo[1,5-a]pyridylboronic acids and esters, and the first results on Suzuki cross-coupling reactions with these new compounds and [1,2,3]triazolo[5,1-a]isoquinolylboronic acid, reacting with a variety of aryl halides as a route to 7-aryltriazolopyridines and 5-aryltriazoloisoquinolines. (C) 2004 Elsevier Ltd. All rights reserved.
• Synthesis of novel fluorescent 3-aryl- and 3-methyl-7-aryl-[1,2,3]triazolo[1,5-a]pyridines by Suzuki cross-coupling reactions
  作者：Belén Abarca、Ricardo Aucejo、Rafael Ballesteros、Fernando Blanco、Enrique García-España

  DOI：10.1016/j.tetlet.2006.09.051

  日期：2006.11

  Two series of compounds, 3-aryl-(series A, compounds 2a-j) and 3-methyl-7-aryl-[1,2,3]triazolo[1,5-a]pyridines (series B, compounds 3a-j) have been synthesized by Suzuki cross-coupling reactions, with a triazolopyridine halide and an aryl or heteroaryl boronic acid in moderate to good yields. All compounds obtained are fluorescents, the quantum yields, particularly those of compounds 3f-f, are very high. (c) 2006 Elsevier Ltd. All rights reserved.